Photoelectrochemical imaging of single cardiomyocytes and monitoring of their action potentials through contact force manipulation of organoids

Jacques, Rachel; Zhou, Bo; Marhuenda, Emilie; Gorecki, Jon; Das, Anirban; Iskratsch, Thomas; Krause, Steffi

doi:10.1016/j.bios.2022.115024

Cited by 7 publications

(5 citation statements)

References 30 publications

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“…Many studies are especially oriented to the detection of clinical biomarkers such as circulating tumor cells [96], alphafetoprotein [97], 1,5-anhydroglucitol [98], glypican-3 [99], and low-density lipoprotein [100]. The light-addressing technologies are also applied to cells, including the detection of extracellular acidification due to metabolism [67,101], light absorption of live cells [102], action potentials of cardiomyocytes [103], and apoptosis [104]. Finally, new measurement modalities have also been explored, including the combination of square-wave voltammetry and light-addressing technology [105], as well as the use of a scanning electron beam instead of a light beam for excitation of carriers in a semiconductor [106,107].…”

Section: Discussionmentioning

confidence: 99%

Field-Effect Sensors Combined with the Scanned Light Pulse Technique: From Artificial Olfactory Images to Chemical Imaging Technologies

Yoshinobu,

Miyamoto,

Wagner

et al. 2024

Chemosensors

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The artificial olfactory image was proposed by Lundström et al. in 1991 as a new strategy for an electronic nose system which generated a two-dimensional mapping to be interpreted as a fingerprint of the detected gas species. The potential distribution generated by the catalytic metals integrated into a semiconductor field-effect structure was read as a photocurrent signal generated by scanning light pulses. The impact of the proposed technology spread beyond gas sensing, inspiring the development of various imaging modalities based on the light addressing of field-effect structures to obtain spatial maps of pH distribution, ions, molecules, and impedance, and these modalities have been applied in both biological and non-biological systems. These light-addressing technologies have been further developed to realize the position control of a faradaic current on the electrode surface for localized electrochemical reactions and amperometric measurements, as well as the actuation of liquids in microfluidic devices.

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Section: Discussionmentioning

confidence: 99%

Field-Effect Sensors Combined with the Scanned Light Pulse Technique: From Artificial Olfactory Images to Chemical Imaging Technologies

Yoshinobu,

Miyamoto,

Wagner

et al. 2024

Chemosensors

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“…However, due to contact problem, the image of an individual cell cannot be obtained in ref . Furthermore, Jacques et al design a photoelectrochemical imaging system (PEI) integrating SOS LAPS, which improves the contact between cells and sensor surfaces by applying pressure to the organoid. PEI can clearly obtain images with two cardiomyocyte cells.…”

Section: Technology Of High-resolution Imaging For Lapsmentioning

confidence: 99%

Light Addressable Potentiometric Sensors for Biochemical Imaging on Microscale: A Review on Optimization of Imaging Speed and Spatial Resolution

Luo,

Liu,

Chen

et al. 2023

ACS Omega

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Light addressable potentiometric sensors (LAPS) are a competitive tool for unmarked biochemical imaging, especially imaging on microscale. It is essential to optimize the imaging speed and spatial resolution of LAPS since the imaging targets of LAPS, such as cell, microfluidic channel, etc., require LAPS to image at the micrometer level, and a fast enough imaging speed is a prerequisite for the dynamic process involved in biochemical imaging. In this study, we discuss the improvement of LAPS in terms of imaging speed and spatial resolution. The development of LAPS in imaging speed and spatial resolution is demonstrated by the latest applications of biochemistry monitoring and imaging on the microscale.

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“…Also, the strong redox ability of photogenerated charges reduces the dependence on the applied potential, thus endowing PEC sensing superior performance compared to electrochemical analysis [42]. Owing to these advantages, PEC sensing has been widely used in many fields such as disease diagnosis [43][44][45], health monitoring [46][47][48], and medical science [49,50]. Meanwhile, it meets the demand for rapid, convenient, sensitive, and accurate detection of pesticide residues in food and environmental samples [41,51,52].…”

Section: Introductionmentioning

confidence: 99%

Recent Progress in Photoelectrochemical Sensing of Pesticides in Food and Environmental Samples: Photoactive Materials and Signaling Mechanisms

Song,

Chen,

et al. 2024

Molecules

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Pesticides have become an integral part of modern agricultural practices, but their widespread use poses a significant threat to human health. As such, there is a pressing need to develop effective methods for detecting pesticides in food and environmental samples. Traditional chromatography methods and common rapid detection methods cannot satisfy accuracy, portability, long storage time, and solution stability at the same time. In recent years, photoelectrochemical (PEC) sensing technology has gained attention as a promising approach for detecting various pesticides due to its salient advantages, including high sensitivity, low cost, simple operation, fast response, and easy miniaturization, thus becoming a competitive candidate for real-time and on-site monitoring of pesticide levels. This review provides an overview of the recent advancements in PEC methods for pesticide detection and their applications in ensuring food and environmental safety, with a focus on the categories of photoactive materials, from single semiconductor to semiconductor–semiconductor heterojunction, and signaling mechanisms of PEC sensing platforms, including oxidation of pesticides, steric hindrance, generation/decrease in sacrificial agents, and introduction/release of photoactive materials. Additionally, this review will offer insights into future prospects and confrontations, thereby contributing novel perspectives to this evolving domain.

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Photoelectrochemical imaging of single cardiomyocytes and monitoring of their action potentials through contact force manipulation of organoids

Cited by 7 publications

References 30 publications

Field-Effect Sensors Combined with the Scanned Light Pulse Technique: From Artificial Olfactory Images to Chemical Imaging Technologies

Field-Effect Sensors Combined with the Scanned Light Pulse Technique: From Artificial Olfactory Images to Chemical Imaging Technologies

Light Addressable Potentiometric Sensors for Biochemical Imaging on Microscale: A Review on Optimization of Imaging Speed and Spatial Resolution

Recent Progress in Photoelectrochemical Sensing of Pesticides in Food and Environmental Samples: Photoactive Materials and Signaling Mechanisms

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