Photoeffects in Condensed Aromatic Hydrocarbons

Northrop, D. C.; Simpson, O.

doi:10.1088/0370-1301/68/11/425

Cited by 26 publications

(18 citation statements)

References 4 publications

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“…Despite gross structural differences, the active sites of all three classes function with a single zinc atom essential for catalysis (6,7). Kinetic studies indicate that all three classes employ a two-step isomechanism (8). The first step is the nucleophilic attack of a zinc-bound hydroxide ion on CO 2 (Equation 2).…”

Section: Common Properties Of the Three Classesmentioning

confidence: 99%

Carbonic Anhydrase: New Insights for an Ancient Enzyme

Tripp¹,

Smith²,

Ferry

2001

Journal of Biological Chemistry

498

393

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Section: Common Properties Of the Three Classesmentioning

confidence: 99%

Carbonic Anhydrase: New Insights for an Ancient Enzyme

Tripp¹,

Smith²,

Ferry

2001

Journal of Biological Chemistry

498

393

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“…6 Studying enzymatic reactions by MS resulted in the determination of kinetic parameters, reaction pathways or regulator identification. [7][8][9][10] Since biological enzymes usually show their full activity only in aqueous media, enzymatic reactions are mostly studied in aqueous solutions. In classical biology, the activities of enzymes are typically lower in non-aqueous systems, this difference is primarily caused by denaturation effects.…”

Section: Introductionmentioning

confidence: 99%

Real-time ESI-MS of Enzymatic Conversion: Impact of Organic Solvents and Multiplexing

2012

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“…228 This approach did not require radiolabeled substrates and it provided the unambiguous identification of mechanistically significant intermediates. Northrop and Simpson 229 recently reviewed several experiments on enzyme kinetics using ESI-MS.…”

Section: Enzymatic Processesmentioning

confidence: 99%

Unravelling seemingly complex chemistry of reactions using electrospray ionization mass spectrometry

Bakhtiar

Hop

1999

J. Phys. Org. Chem.

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Since its discovery, electrospray ionization mass spectrometry (ESI-MS) has provided valuable information on structurally specific biomolecular interactions, including DNA-drug, enzyme-inhibitor, DNAprotein and protein-protein interactions. In addition, this technique has emerged as a powerful tool in probing the structural modification of large molecules. However, ESI-MS has been underutilized in analysis and mechanistic studies involving small molecules. Here, a brief overview is presented to familiarize non-specialists with ESI-MS applications in analysis and mechanistic studies of small molecules. For more advanced applications (e.g. biopolymers) or detailed analytical descriptions of the ionization processes and the equipment, readers are referred to a number of excellent reviews and books.

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Photoeffects in Condensed Aromatic Hydrocarbons

Cited by 26 publications

References 4 publications

Carbonic Anhydrase: New Insights for an Ancient Enzyme

Carbonic Anhydrase: New Insights for an Ancient Enzyme

Real-time ESI-MS of Enzymatic Conversion: Impact of Organic Solvents and Multiplexing

Unravelling seemingly complex chemistry of reactions using electrospray ionization mass spectrometry

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