Photodynamic treatment with purpurin 18 effectively inhibits triple negative breast cancer by inducing cell apoptosis

Huang, Pengyun; Zhang, Bao-Ting; Yuan, Qiuju; Xie, Zhaoxiong; Leung, Albert Wingnang; Xu, Chi

doi:10.1007/s10103-020-03035-w

Cited by 17 publications

(10 citation statements)

References 14 publications

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“…Moreover, the results depicts that light‐activated purpurin‐18 could significantly prevent tumor growth without influencing major organ function and increasing survivability. Hence, it confirms that a combination of purpurin‐18 and light irradiation could be a potent therapy in the treatment of breast cancer (Huang et al, 2020). Further, Zhang et al (2015) suggested a new method for the discovery of high‐performance imaging probe by synthesizing a nanoprobe, made of ammonium hydrogen carbonate payload with signal self‐amplifiable photoacoustic liposome and accumulated with purpurin‐18 confined by the bilayer (Zhang et al, 2018).…”

Section: Pharmacological Activities Of Purpurinsupporting

confidence: 60%

“…It suggests that purpurin-18 distributes throughout the endoplasmic reticulum, golgi apparatus, mitochondria, and lysosomes. Also, it showed significant photo-cytotoxicity against 2D and 3D 4 T1 breast cancer cells by generating ROS, leading to the Hence, it confirms that a combination of purpurin-18 and light irradiation could be a potent therapy in the treatment of breast cancer (Huang et al, 2020). Further, Zhang et al (2015) suggested a new method for the discovery of high-performance imaging probe by synthesizing a nanoprobe, made of ammonium hydrogen carbonate payload with signal self-amplifiable photoacoustic liposome and accumulated with purpurin-18 confined by the bilayer (Zhang et al, 2018).…”

Section: Antioxidant Propertymentioning

confidence: 55%

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Purpurin: A natural anthraquinone with multifaceted pharmacological activities

Singh

Hussain

Luqman

et al. 2020

Phytotherapy Research

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Purpurin is a naturally occurring anthraquinone isolated from the roots of Rubia cordifolia. Historically, it has been used as a red dye. However, its photosensitizing property and biological effects have deciphered its novel application. Purpurin shows antigenotoxic, anticancer, neuromodulatory, and antimicrobial potential associated with antioxidant action in in vivo and in vitro experiments. A robust antioxidant nature of purpurin is responsible for the majority of its pharmacological effects. It produces anti-inflammatory activity by reducing oxidative stress, which is a fundamental property to target diseases involving endoplasmic reticulum and mitochondrial stress. It can cross the blood-brain barrier and produce neuroprotective effects, including antidepressant and anti-Alzheimer action. It shows antimutagenic property via inhibiting essential CYP-450 enzymes. Interestingly, it gets photosensitized by UVlight and produces target-specific ROS-dependent apoptosis in cancer cells. Therefore, it owns cell killing and cell survival potential subject to the influence of external conditions. Hitherto, limited research studies are performed with purpurin to understand its therapeutic potential. Hence, this review describes and discusses different in vivo, in vitro, and in silico studies performed using purpurin. It also covers physicochemical, pharmacokinetics, and toxicology aspects of purpurin. Moreover, in the end, the prospect of purpurin in the management of cancer has also been proposed.

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Section: Pharmacological Activities Of Purpurinsupporting

confidence: 60%

Section: Antioxidant Propertymentioning

confidence: 55%

Purpurin: A natural anthraquinone with multifaceted pharmacological activities

Singh

Hussain

Luqman

et al. 2020

Phytotherapy Research

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“…[ 152 ] Purpurin‐18‐mediated PDT has been recently shown to prevent the growth of triple‐negative breast cancer, both in vitro and in vivo. [ 153 ]…”

Section: Light‐activated Biomedical Applications Of Chlorophyll Derivativesmentioning

confidence: 99%

Light‐Activated Biomedical Applications of Chlorophyll Derivatives

Pucci

Martinelli

Degl’Innocenti

et al. 2021

Macromolecular Bioscience

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Tetrapyrroles are the basis of essential physiological functions in most living organisms. These compounds represent the basic scaffold of porphyrins, chlorophylls, and bacteriochlorophylls, among others. Chlorophyll derivatives, obtained by the natural or artificial degradation of chlorophylls, present unique properties, holding great potential in the scientific and medical fields. Indeed, they can act as cancer‐preventing agents, antimutagens, apoptosis inducers, efficient antioxidants, as well as antimicrobial and immunomodulatory molecules. Moreover, thanks to their peculiar optical properties, they can be exploited as photosensitizers for photodynamic therapy and as vision enhancers. Most of these molecules, however, are highly hydrophobic and poorly soluble in biological fluids, and may display undesired toxicity due to accumulation in healthy tissues. The advent of nanomedicine has prompted the development of nanoparticles acting as carriers for chlorophyll derivatives, facilitating their targeted administration with demonstrated applicability in diagnosis and therapy. In this review, the chemical and physical properties of chlorophyll derivatives that justify their usage in the biomedical field, with particular regard to light‐activated dynamics are described. Their role as antioxidants and photoactive agents are discussed, introducing the most recent nanomedical applications and focusing on inorganic and organic nanocarriers exploited in vitro and in vivo.

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“…Several classes of molecules, such as tetrapyrrolic macrocycles and analogues, including porphyrins [64][65][66][67][68][69][70][71], phthalocyanines [72,73], chlorins [22,23,[74][75][76][77][78][79][80][81][82][83][84][85][86], the prodrug 5-aminolevulinic acid (5-ALA) [87][88][89] and other dyes, such as adequately conjugated indocyanine green [90][91][92][93][94], have been explored as PS in TNBC targeted therapy. Chlorins and their analogues are very interesting molecules; besides their natural source and/or semi-synthetic preparation, these molecules exhibit good absorption in the therapeutic window (600-800 nm), which is an important feature for a good candidate for clinical PDT, due to the better light penetration in tissues (≈1-2 cm), which overcomes the light penetration limitation when other photosensitizers are used, such as porphyrins [48,49,95].…”

Section: Targeted Therapy In Triple-negative Breast Cancermentioning

confidence: 99%

Current Photoactive Molecules for Targeted Therapy of Triple-Negative Breast Cancer

2021

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Cancer is the second leading cause of death worldwide; therefore, there is an urgent need to find safe and effective therapies. Triple-negative breast cancer (TNBC) is diagnosed in ca. 15–20% of BC and is extremely aggressive resulting in reduced survival rate, which is mainly due to the low therapeutic efficacy of available treatments. Photodynamic therapy (PDT) is an interesting therapeutic approach in the treatment of cancer; the photosensitizers with good absorption in the therapeutic window, combined with their specific targeting of cancer cells, have received particular interest. This review aims to revisit the latest developments on chlorin-based photoactive molecules for targeted therapy in TNBC. Photodynamic therapy, alone or combined with other therapies (such as chemotherapy or photothermal therapy), has potential to be a safe and a promising approach against TNBC.

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Photodynamic treatment with purpurin 18 effectively inhibits triple negative breast cancer by inducing cell apoptosis

Cited by 17 publications

References 14 publications

Purpurin: A natural anthraquinone with multifaceted pharmacological activities

Purpurin: A natural anthraquinone with multifaceted pharmacological activities

Light‐Activated Biomedical Applications of Chlorophyll Derivatives

Current Photoactive Molecules for Targeted Therapy of Triple-Negative Breast Cancer

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