Photodynamic therapy with topical methyl aminolaevulinate for 'difficult-to-treat' basal cell carcinoma

Vinciullo, Carl; Elliott, Tim; Francis, David M.; Gebauer, Kurt; Spelman, Lynda; Nguyen, Richard D.; Weightman, Warren; Sheridan, Adam T; Reid, Catherine; Czarnecki, D.; Murrell, D.F.

doi:10.1111/j.1365-2133.2005.06484.x

Cited by 142 publications

(135 citation statements)

References 21 publications

(34 reference statements)

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“…Moreover, because PDT is a noninvasive procedure causing minimal damage to surrounding tissue, it offers advantages over excision surgery, particularly for the treatment of lesions in cosmetically sensitive areas, such as the face. [1][2][3] However, long-term follow-up data of controlled clinical trials of topical PDT vs excision surgery (regarded as the treatment of choice for nodular BCC) 4,5 are lacking. We performed a prospective, randomized, multicenter study of simple excision surgery vs topical PDT, using methyl aminolevulinate, a drug showing highly selective uptake by malignant cells, 6 in the treatment of primary nodular BCC.…”

mentioning

confidence: 99%

Five-Year Follow-up of a Randomized, Prospective Trial of Topical Methyl Aminolevulinate Photodynamic Therapy vs Surgery for Nodular Basal Cell Carcinoma

Rhodes¹,

Rie²,

Leifsdottir³

et al. 2007

Arch Dermatol

238

206

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mentioning

confidence: 99%

Five-Year Follow-up of a Randomized, Prospective Trial of Topical Methyl Aminolevulinate Photodynamic Therapy vs Surgery for Nodular Basal Cell Carcinoma

Rhodes¹,

Rie²,

Leifsdottir³

et al. 2007

Arch Dermatol

238

206

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“…Data from other studies support that PDT leads to better cosmetic results compared to surgical excision [81,82]. Also PDT serves as an effective alternative treatment option in difficult cases where an extensive surgical excision should have been performed carrying the risk of a worse cosmetic outcome [84].…”

Section: Basal Cell Carcinomamentioning

confidence: 97%

Photodynamic Therapy and Skin Cancer

Papakonstantinou¹,

Löhr²,

Raap³

2018

Dermatologic Surgery and Procedures

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Non-melanoma skin cancer (NMSC) is the most common type of cancer among white skin individuals worldwide with an increasing incidence over the last years. NMSC is mostly treated with surgical or non-invasive methods such as cryotherapy or topical chemotherapeutics. Over the last years, there has been a rapidly growing interest in the use of photodynamic therapy (PDT) which is a well-tolerated, safe and effective alternative treatment option. PDT involves a photosensitizer, a light source and tissue oxygen and is based on a photo-oxidation reaction in the target tissue which results to a selective destruction of the cancer cells. PDT has been approved for treatment of actinic keratosis, Bowen's disease and basal cell carcinoma in Europe. Off-label uses include treatment of invasive squamous cell carcinoma, cutaneous T-cell lymphoma, Kaposi's sarcoma, Paget's disease and prevention of recurrence of squamous cell carcinoma in organ-transplant recipients. Also combination of PDT with other treatment options such as cryotherapy, surgery and topical therapies has been reported with improved efficacy, tolerability and long-term results. Development of novel photosensitizers and light sources together with targeted delivery systems will increase specificity, efficiency and treatment field of PDT in the future. This chapter aims to give the reader an overview of the important applications of PDT, including indications, approved treatments, advantages and disadvantages of this method such as future trends.

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“…Several prospective studies have demonstrated the efficacy and safety of MAL-PDT in the treatment of superficial and nodular BCCs [6,7,8,9,10]. Yet, in analogy to other destructive and non-histology-controlled treatments (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…For BCCs, the primary endpoint of most clinical studies has been the complete response rate [6,7,8,9,10]. However, no study has focused on those BCCs recurring after PDT.…”

Section: Introductionmentioning

confidence: 99%

Facial Basal Cell Carcinomas Recurring after Photodynamic Therapy: A Retrospective Analysis of Histological Subtypes

et al. 2012

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Background: Photodynamic therapy (PDT) is an established treatment for basal cell carcinomas (BCCs). Although recurrences are sometime observed, their histological patterns have never been specifically studied or compared with the one of the initial tumor. Objective: To compare the histopathological aggressiveness of BCCs recurring after PDT with that of the primary tumors. Methods: The study population included 12 patients with 16 post PDT recurrent BCCs. Outcome measures were proportion of histologically aggressive subtypes in BCC recurrences vs. primary tumor. Results: 62.5% of recurrent BCCs displayed a transition from a non-aggressive to an aggressive subtype. Conclusions: Post PDT recurrences appear to display an increased histological aggressiveness, although the latter may reflect the natural course of tumor progression. Despite the presence of potential biases, our study raises the possibility that PDT favors the selection of more aggressive tumor cells. Better systematic large-scale follow-up studies are required to assess the exact frequency and histological types of BCC recurrences after PDT.

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Photodynamic therapy with topical methyl aminolaevulinate for 'difficult-to-treat' basal cell carcinoma

Abstract: MAL PDT is an attractive option for 'difficult-to-treat' BCC. Because of the excellent cosmetic results, the treatment is particularly well suited for lesions that would otherwise require extensive surgical procedures.

Cited by 142 publications

References 21 publications

Five-Year Follow-up of a Randomized, Prospective Trial of Topical Methyl Aminolevulinate Photodynamic Therapy vs Surgery for Nodular Basal Cell Carcinoma

Five-Year Follow-up of a Randomized, Prospective Trial of Topical Methyl Aminolevulinate Photodynamic Therapy vs Surgery for Nodular Basal Cell Carcinoma

Photodynamic Therapy and Skin Cancer

Facial Basal Cell Carcinomas Recurring after Photodynamic Therapy: A Retrospective Analysis of Histological Subtypes

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