Photodynamic therapy with paclitaxel-encapsulated indocyanine green-modified liposomes for breast cancer
Mariko Ishizuka,
Masaki Kaibori,
Fusao Sumiyama
et al.
Abstract:BackgroundPhotodynamic therapy (PDT) involves the administration of a photosensitizing agent and irradiation of light at an excitation wavelength that damages tumor cells without causing significant damage to normal tissue. We developed indocyanine green (ICG)-modified liposomes in which paclitaxel (PTX) was encapsulated (ICG-Lipo-PTX). ICG-Lipo-PTX accumulates specifically in tumors due to the characteristics of the liposomes. The thermal and photodynamic effects of ICG and the local release of PTX by irradia… Show more
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