Photodynamic therapy using meta-tetrahydroxyphenylchlorin (FoscanR) for the treatment of vulval intraepithelial neoplasia

Campbell, S.; Gould, David; Salter, Leo; Clifford, Tim; Curnow, Alison

doi:10.1111/j.1365-2133.2004.06197.x

Cited by 41 publications

(29 citation statements)

References 11 publications

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“…Surgical excision can be mutilating and a technique like PDT, which has the potential to destroy the disease process with healing by regeneration of normal tissue rather than with significant scarring, is a most attractive option. Pilot clinical studies of PDT have been undertaken for all these conditions, with promising results, but full clinical trials are now needed to establish for which ones PDT might become the treatment of choice [34,35]. In theory, pre-cancers or early cancers of any solid or hollow organ may be suitable for PDT, but for this to become a realistic option, studies must be done to establish how the normal organ in which these lesions arise will respond to PDT and that the treatment will not lead to any unacceptable changes in structure or function at any time during healing.…”

Section: (Xi) Breastmentioning

confidence: 99%

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Photodynamic therapy for photochemists

Bown

2013

Phil. Trans. R. Soc. A.

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One contribution of 18 to a Discussion Meeting Issue 'Photoactivatable metal complexes: from theory to applications in biotechnology and medicine' . Photodynamic therapy (PDT) is an evolving technique for localized control of diseased tissue with light after prior administration of a photosensitizing agent and in the presence of oxygen. The biological effect is quite different from surgery, radiotherapy and chemotherapy. With no temperature change during treatment, connective tissues like collagen are largely unaffected, so maintaining the mechanical integrity of hollow organs. PDT is of particular value for precancer and early cancers of the skin (not melanomas) and mouth as the cosmetic and functional results are so good. Another key indication is for small areas of cancer that are unsuitable for or have persisted or recurred after conventional management. It can be applied in areas already exposed to the maximum safe dose of radiotherapy. Outside cancer, in ophthalmology, it is established for agerelated macular degeneration, and has considerable potential in arterial disease for preventing restenosis after balloon angioplasty and in the treatment of infectious diseases, where the responsible organisms are accessible to both the photosensitizer and light. New developments on the horizon include techniques for increasing the selectivity for cancers, such as coupling photosensitizers to antibodies, and for stimulating immunological responses, but many further pre-clinical and clinical studies are needed to establish PDT's role in routine clinical practice.

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Section: (Xi) Breastmentioning

confidence: 99%

“…PD is an approved technique for guiding glioma resection during open surgery (as discussed under brain tumours) and also for guiding endoscopic resection of dysplastic (pre-cancerous) areas in the bladder [11,34].…”

Section: (Xiii) Photodiagnosismentioning

confidence: 99%

Photodynamic therapy for photochemists

Bown

2013

Phil. Trans. R. Soc. A.

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“…The efficacy of Foscan s -PDT in the treatment of early squamous cell carcinoma Lou et al, 2004) and other malignancies has also been recently reported (Campbell et al, 2004;Lovat et al, 2005;Shikowitz et al, 2005). Endoplasmic reticulum and Golgi apparatus have been demonstrated as preferential sites of Foscan s accumulation in cultured tumour cells after 3-h incubation (Teiten et al, 2003a) leading to primary photodamage of these organelles upon irradiation (Teiten et al, 2003b).…”

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confidence: 99%

Relationship between subcellular localisation of Foscan® and caspase activation in photosensitised MCF-7 cells

et al. 2007

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The present study investigates the relationship between the subcellular localisation of Foscan s and intrinsic apoptotic pathway post Foscan s -based photodynamic therapy (PDT). With this purpose, mammary carcinoma MCF-7 cells were incubated with Foscan s for 3 or 24 h and then subjected to equitoxic light doses. Fluorescence microscopy revealed very good Foscan s co-localization to endoplasmic reticulum (ER) and Golgi apparatus after 3 h incubation with MCF-7 cells. Progressive increase in incubation time shows leakage of Foscan s from Golgi apparatus. Twenty-four hours incubation yielded a fluence-dependent enhanced induction of the ERresident glucose-regulated protein 78 (Bip/GRP78), along with a weak mitochondrial damage, thus underscoring the ER as the main site of photodamage after prolonged incubation. Analysis of events implicated in apoptotic pathway after 24 h incubation demonstrated photodamage to Bcl-2 protein in total cellular extract, but not in the mitochondrial fraction. We further determined an increase in caspases-7 and -6 activation, which was strongly related to the expression of GRP78. The above findings demonstrate that Foscan s localisation in ER improves the photoactivation of the caspase-7 apoptotic pathway, which is poorly related to mitochondrial damage.

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“…124 After multiple sessions, ALA PDT can achieve long-term results lasting several months and years in some 60% of patients. Although other systemic PSs have been used in a small number of patients, 127 the results are not consistent or sufficiently reproducible and there is the inconvenience of skin photosensitivity.…”

Section: Vulvar Intraepithelial Neoplasiamentioning

confidence: 99%

Untitled

2015

Surg J

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Photodynamic therapy using meta-tetrahydroxyphenylchlorin (FoscanR) for the treatment of vulval intraepithelial neoplasia

Cited by 41 publications

References 11 publications

Photodynamic therapy for photochemists

Photodynamic therapy for photochemists

Relationship between subcellular localisation of Foscan® and caspase activation in photosensitised MCF-7 cells

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