Photodynamic therapy using aminolaevulinic acid does not lead to clinical improvement in hidradenitis suppurativa

Strauss, R.M.; Pollock, Bruce G.; Stables, G.I.; Goulden, V.; Cunliffe, W. J.

doi:10.1111/j.1365-2133.2005.06475.x

Cited by 78 publications

(44 citation statements)

References 9 publications

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“…22 Other types of management reported include radiotherapy, carbondioxide 23 and diode laser treatment, 24 and photodynamic therapy. 25,26 In 2007, a stepwise approach to management of HS was well described by Lam The overall percent improvement of hidradenitis suppurativa lesions treated with the laser was statistically significant compared with the control side. The suggested mechanisms of action include release of obstruction of the hair follicle and photothermolysis.…”

mentioning

confidence: 95%

Prospective controlled clinical and histopathologic study of hidradenitis suppurativa treated with the long-pulsed neodymium:yttrium-aluminium-garnet laser

Mahmoud

Tierney

Hexsel

et al. 2010

Journal of the American Academy of Dermatology

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mentioning

confidence: 95%

Prospective controlled clinical and histopathologic study of hidradenitis suppurativa treated with the long-pulsed neodymium:yttrium-aluminium-garnet laser

Mahmoud

Tierney

Hexsel

et al. 2010

Journal of the American Academy of Dermatology

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“…15 Strauss et al report negative results similar with our study. 12 Strauss also mentioned the limited penetration of ALA and light in¯stula and¯brotic lesions. The late stage may reduce the e±cacy.…”

Section: Discussionmentioning

confidence: 99%

“…The previous study of ALA-PDT on HS showed converse results. [12][13][14][15] Gold et al reported an improvement of 75-100% in four patients. 14 Schweiger et al observed a 50% reduction in mean lesion count after four weeks and a 29% reduction after eight weeks.…”

Section: Discussionmentioning

confidence: 99%

Topical 5-aminolevulinic acid photodynamic therapy improved refractory acne conglobata and perifolliculitis capitis abscedens et suffodiens rather than hidradenitis suppurativa

Zhang

Wang

Shi

et al. 2016

J. Innov. Opt. Health Sci.

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Acne conglobata (AC), perifolliculitis capitis abscedens et su®odiens (PCAS) and hidradenitis suppurativa (HS) are uncommon refractory chronic, in°ammatory, scarring diseases but cause serious damage to the quality of life. These three diseases are associated with follicular occlusion. Several studies indicated topical 5-aminolevulinic acid photodynamic therapy (ALA-PDT) improved follicular occlusion besides acne treatment. So we attempted to apply ALA-PDT to medicine resistant AC, PCAS and HS. Topical ALA-PDT was applied to 10 patients with AC, seven patients with PCAS and three patients with HS for more than three sessions. All the patients completed the dermatology life quality index (DLQI) questionnaire and were assessed for the e±cacy at the baseline and on two weeks after each treatment. Adverse e®ects were recorded at each visit. The results showed 25.5% (5/20, two cases of AC and three cases of PCAS) of patients achieved excellent improvement after three sessions of PDT and another 60. HS) got poor response (< 20% lesions clearance). Another¯ve cases (three cases of AC and two cases of PCAS) also achieved excellent response after 5-7 sessions of PDT. We also found that papular/nodular, cyst/abscess showed higher clearance rate than sinus/¯stula (88.5%, 86.1% versus 11.1%). DLQI was reduced after three sessions of PDT in AC and PCAS patients rather than HS patients. 5-ALA-PDT could improve refractory AC and PCAS but could not lead to improvement in late stage of HS. The e±cacy increased with more treatment sessions.

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“…The role of bacteria in the pathogenesis of HS is controversial, with some cultures from early superficial lesions frequently being negative. Second, in long-standing HS, there is deep scarring involved, making the penetration of the ALA very difficult [41]. Passeron et al treated four HS patients using the methyl aminolevulinate and pulsed dye laser.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Laser and light-based treatments of hidradenitis suppurativa

Yang¹,

2012

Expert Review of Dermatology

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Photodynamic therapy using aminolaevulinic acid does not lead to clinical improvement in hidradenitis suppurativa

Cited by 78 publications

References 9 publications

Prospective controlled clinical and histopathologic study of hidradenitis suppurativa treated with the long-pulsed neodymium:yttrium-aluminium-garnet laser

Prospective controlled clinical and histopathologic study of hidradenitis suppurativa treated with the long-pulsed neodymium:yttrium-aluminium-garnet laser

Topical 5-aminolevulinic acid photodynamic therapy improved refractory acne conglobata and perifolliculitis capitis abscedens et suffodiens rather than hidradenitis suppurativa

Laser and light-based treatments of hidradenitis suppurativa

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