Photodynamic therapy using a second generation photosensitizer, Talaporfin

Kondo, Kazuya; Miyoshi, Takanori; Fujino, Haruhiko; Takizawa, Hiromitsu; Imai, Satoshi; Kobayashi, Naoki; Kenzaki, Koichiro; Shoji, Shuichi; Tangoku, Akira

doi:10.1016/j.pdpdt.2007.06.001

Cited by 24 publications

(8 citation statements)

References 9 publications

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“…The NPe6 concentration in plasma between 5 minutes and 1 hour after the administration of 5 or 10 mg/kg NPe6 to the pigs ( n = 2) during the procedure was measured. The plasma concentration of NPe6 decreased with time, exhibiting kinetics similar to previously reported data 24. Similar to that reported in humans, the observed decay curve of plasma concentration with time could be divided in two phases 17: the measured elimination half‐life was about 7 minutes in the initial rapid exponential decline (the first phase) and about 77 minutes in the subsequent slower exponential decline (the second phase).…”

Section: Resultssupporting

confidence: 86%

Myocardial electrical conduction block induced by photosensitization reaction in exposed porcine hearts in vivo

et al. 2011

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Section: Resultssupporting

confidence: 86%

Myocardial electrical conduction block induced by photosensitization reaction in exposed porcine hearts in vivo

et al. 2011

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“…The oximetry measurements decreased to 94.7±0.8% of baseline after photosensitizer administration; however, the actual oxygen saturation has previously been reported to be unchanged. 15 The conduction block was confirmed in all of the canines after 16±7 applications of irradiation with a total laser energy of Figure 2G. Under pacing from the coronary sinus ostium, the conduction time to the ablation catheter placed on the lateral side of the CTI was 12±4 ms before ablation, and this increased to 76±5 ms after the CTI block.…”

Section: Cti Ablationmentioning

confidence: 81%

Nonthermal Cardiac Catheter Ablation Using Photodynamic Therapy

Kimura

Takatsuki

Miyoshi

et al. 2013

Circ: Arrhythmia and Electrophysiology

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Background-Radiofrequency ablation has limitations, largely related to creation of lesions by heating. Here, we report the first nonthermal ablation by applying photodynamic therapy (PDT) to cardiac tissues using a custom-made deflectable laser catheter. The present study investigated the feasibility of PDT for cavotricuspid isthmus ablation in a canine model. Methods and Results-We evaluated the pharmacokinetic profiles of 17 canines after administration of a photosensitizer (talaporfin sodium) by various protocols. We succeeded in maintaining the photosensitizer concentration at a level in excess of the clinically effective dose for humans. Using a 4-polar 7-French deflectable laser catheter, we performed PDT-mediated cavotricuspid isthmus ablation in 8 canines. PDT caused oxidative injury only to the irradiated area and successfully produced a persistent electric conduction block. No acute, gross changes such as edematous degeneration, thrombus formation, steam pops, or traumatic injury were observed after irradiation. Hematoxylin and eosin staining of tissues samples also showed well-preserved endothelial layers. Testing of the blood samples taken before and after the procedure revealed no remarkable changes. Lesion size at 2 weeks after the procedure and the temperature data collected during irradiation were compared between the PDT and irrigated radiofrequency ablation procedures. A ventricular crosssection revealed a solid PDT lesion, which was as deep as a radiofrequency lesion. In addition, endocardial, surficial, and intramural temperature monitoring during the PDT irradiation clearly demonstrated the nonthermal nature of the ablation technique. Conclusions-Nonthermal PDT-mediated catheter ablation is a potentially novel treatment for cardiac arrhythmias.(Circ Arrhythm Electrophysiol. 2013;6:1025-1031.)

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“…This drug is mainly metabolised in the liver and is excreted more rapidly from the body than the first‐generation photosensitisers (Kondo et al . , Akimoto et al . ).…”

Section: Introductionmentioning

confidence: 99%

Endoscopic photodynamic therapy using talaporfin sodium for recurrent intranasal carcinomas after radiotherapy in three dogs

Ishigaki

Nariai

Izumi

et al. 2017

J of Small Animal Practice

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Radiation is the treatment of choice for canine nasal tumours but, in almost all cases, there is local recurrence associated with poor prognosis. This report describes the effect of endoscopic photodynamic therapy using talaporfin sodium for canine intranasal carcinoma recurring after radiation therapy. Rhinoscopic photodynamic therapy was administered after radiation therapy in three dogs with recurrent intranasal carcinoma. Two to 24 illuminations of a 665-nm diode laser were performed two hours after intravenous bolus injection of 5·0 mg/kg of talaporfin sodium. Photodynamic therapy induced almost complete remission and prolonged survival time in all cases suggesting that it might be a useful treatment for intranasal carcinomas that recur after radiation.

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Photodynamic therapy using a second generation photosensitizer, Talaporfin

Cited by 24 publications

References 9 publications

Myocardial electrical conduction block induced by photosensitization reaction in exposed porcine hearts in vivo

Myocardial electrical conduction block induced by photosensitization reaction in exposed porcine hearts in vivo

Nonthermal Cardiac Catheter Ablation Using Photodynamic Therapy

Endoscopic photodynamic therapy using talaporfin sodium for recurrent intranasal carcinomas after radiotherapy in three dogs

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