Photodynamic therapy reduces the histological features of actinic damage and the expression of early oncogenic markers

Bagazgoitia, Lorea; Santos, Jesús Cuevas; Juarranz, Ángeles; Jaén, Pedro

doi:10.1111/j.1365-2133.2011.10270.x

Cited by 62 publications

(49 citation statements)

References 42 publications

(52 reference statements)

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“…5-Fluorouracil, diclofenac, and topical imiquimod are alternatives following this approach strategy to these lesions [4]. After treatment with photodynamic therapy histological evaluation demonstrated an ability to reduce the histological signs of photodamage, reducing the proliferation marker Ki-67 and p53 marker of early carcinogenesis [8]. Interestingly, despite the improvement of the basal keratinocytes dysplasia, as assessed by scale of two different observers, in 45% of cases, there was still some degree of dysplasia.…”

Section: Discussionmentioning

confidence: 99%

Histological Comparison of Two Cryopeeling Methods for Photodamaged Skin

2014

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Background. Cryopeeling is a technique that uses cryotherapy not only on actinic keratoses lesions, but also all over the photodamaged skin. Objectives. To investigate the histological changes induced by two cryopeeling methods (liquid nitrogen (LN) and portable system (PS)). Methods. Sixteen patients (n = 16) with multiple actinic keratoses on the forearms were treated with cryopeeling technique using LN for one forearm and PS for the other, randomly. Skin biopsies were taken before and after the procedures. Results. There was no statistical difference between the epidermal and Grenz zone thicknesses or density of elastic fibers after treatments. The amount of melanin pigment was lower after PS treatment (P < 0.05). In a blind analysis of paired pre- and postprocedure slides, it was not possible to identify cases which underwent treatment, both in global analysis of quality of the skin and in specific analysis (considering only the aspect of stratum corneum). Discussion. The results indicate the inconsistency of histological improvement after treatments, and, likely, since the method causes superficial exfoliation, a reliable marker was not found in the analysis. Conclusions. Despite cosmetic benefits on photodamaged skin and efficient treatment of actinic keratoses lesions, cryopeeling was not able to induce measurable histological changes in solar elastosis, epidermal organization, or epidermal and Grenz zone thicknesses. One should keep in mind the possibility of hypopigmentation risk of the method.

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Section: Discussionmentioning

confidence: 99%

Histological Comparison of Two Cryopeeling Methods for Photodamaged Skin

2014

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“…Histological studies have shown that PDT can reverse actinic skin damage in terms of reducing epidermal expression of immunohistochemical markers of dysplasia, p53, and Ki-67 (16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

Primary Prevention of Skin Dysplasia in Renal Transplant Recipients With Photodynamic Therapy: A Randomized Controlled Trial

Togsverd‐Bo

Omland

Wulf

et al. 2015

American Journal of Transplantation

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Organ transplant recipients (OTRs) are at high risk of developing cutaneous squamous cell carcinoma (SCC); prevention includes early treatment of premalignant actinic keratosis (AK). Photodynamic therapy (PDT) is a noninvasive field therapy that reduces new AKs in patients with existing AK and delays SCC development in mice. We investigated the effect of repeated PDT over 5 years for primary prophylaxis of skin dysplasia. These data represent an interim analysis of an on-going randomized controlled trial. During 2008-2011, 25 renal transplant recipients with clinically normal skin were randomized to split-side PDT of the face, forearm and hand, the contralateral side serving as untreated control. Patients received PDT on inclusion and at 6-monthly intervals for 5 years. Blinded evaluation was performed at each visit. We found that prophylactic PDT significantly delayed onset of AK compared with untreated skin, p ¼ 0.020. At 3-year follow-up, we observed AK in 63% of patients in untreated skin areas compared with 28% of patients in PDT-treated skin, with a total number of cumulated AKs in untreated skin (n ¼ 43) compared with PDT-treated skin (n ¼ 8), p ¼ 0.005. These preliminary data indicate a novel approach to early prevention of skin dysplasia that may reduce morbidity from multiple AKs and SCCs in OTR.

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“…Bagazgoitia et al [18] showed the potential for PDT to reduce actinic damage and elastosis, and to significantly decrease the expression of Ki-67 and TP53. The expression of cyclin D1 remained stable.…”

Section: Discussionmentioning

confidence: 99%

Comparison of “Lesion-by-Lesion” and Field Photodynamic Therapy in the Prevention of Actinic Keratoses: A Randomized, Split-Face, Single-Blind Pilot Study

2016

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Background: Actinic keratoses (AKs) are often treated separately, lesion by lesion. However, in the past years, AKs have been described as a field disease and not limited to single clinically apparent lesions. Treatment should therefore target an area of field change which may reduce the risk of development of further AKs, second tumours, and local recurrence. Objective: The primary objective was to determine the number of new lesions at 9 months after methyl aminolevulinate photodynamic therapy (MAL-PDT). Secondary objectives were to determine the number of new lesions at 3 and 6 months after treatment and the percentage reduction of AKs from baseline at 3, 6, and 9 months after MAL-PDT. Methods: This was a single-centre, prospective, randomized, split-face, investigator-blinded pilot study with a study duration of 1 year. The study population comprised patients with AKs on the face or scalp, with a maximum of 10 AKs on each side. One side was treated with 1 session of “lesion-by-lesion” MAL-PDT (LT side) and the other side with 1 session of field MAL-PDT (FT side). Results: At 9 months the FT demonstrated significantly fewer new lesions. At every time point during the follow-up, we found a significant reduction in the number of AKs in the LT as well as in the FT sides. After 3 and 6 months we did not observe significant differences between the sides. However, after 9 months, the LT area showed significantly fewer remaining AKs, whereas the FT area demonstrated significantly fewer new lesions. Conclusions: Field treatment results in significantly fewer new AK lesions compared with lesion-by-lesion treatment.

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Photodynamic therapy reduces the histological features of actinic damage and the expression of early oncogenic markers

Cited by 62 publications

References 42 publications

Histological Comparison of Two Cryopeeling Methods for Photodamaged Skin

Histological Comparison of Two Cryopeeling Methods for Photodamaged Skin

Primary Prevention of Skin Dysplasia in Renal Transplant Recipients With Photodynamic Therapy: A Randomized Controlled Trial

Comparison of “Lesion-by-Lesion” and Field Photodynamic Therapy in the Prevention of Actinic Keratoses: A Randomized, Split-Face, Single-Blind Pilot Study

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