Photodynamic Therapy Reduces Intimal Hyperplasia in Prosthetic Vascular Bypass Grafts in a Pig Model

Heckenkamp, J.; Mellander, Stefan; Fogelstrand, Per; Breuer, Saida; Brunkwall, Jan; Mattsson, Erney

doi:10.1016/j.ejvs.2007.04.002

Cited by 6 publications

(1 citation statement)

References 28 publications

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“…A liposomal formulation of a highly hydrophobic photosensitizing agent, Zn(II)-phthalocyanine, is readily taken up by cultured VSMCs, and subsequent red light irradiation induced cell death and neointimal hyperplasia in rabbits [144] . Another group has been successful with endovascular methylene blue followed by laser light during surgery in pigs with PTFE grafts [149] . Heparin has already been mentioned as an important constituent of the glycocalyx and binds an epidermal growth factor secreted from macrophages, heparin-binding epidermal-growth-like growth factor, that is activated by reduced endothelial shear stress, stimulates VSMC proliferation and appears to be the signal for proliferation in low shear stress states [150] .…”

Section: Other Future Possibilitiesmentioning

confidence: 99%

Novel Insights into the Pathobiology of the Vascular Access – Do They Translate into Improved Care?

Diskin

2010

Blood Purif

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While recent developments have allowed greater insight into the vascular pathobiology and intimal hyperplasia, very few of these advances have led to improved clinical care of hemodialysis vascular accesses. Indeed the most common procedure for the treatment of access stenosis and thrombosis is the same model for the creation and study of intimal hyperplasia. The evolution of our understanding of vascular thrombosis is reviewed with a current concept that includes a dynamic interplay of the biophysics, chemistry and biology of the blood vessel with the blood and its constituents. Implications for possible future interventions based on these novel concepts are offered, and the significance of improving our understanding of the pathobiology is emphasized.

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Section: Other Future Possibilitiesmentioning

confidence: 99%

Novel Insights into the Pathobiology of the Vascular Access – Do They Translate into Improved Care?

Diskin

2010

Blood Purif

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Photodynamic therapy of balloon-injured rat carotid arteries using indocyanine green

Lin

Wang

2018

Lasers Med Sci

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Photodynamic therapy (PDT) has been used to inhibit intimal hyperplasia in injured arteries. Because of the limited tissue penetration of visible light, an endovascular light source with a guided wire is often required for effective treatment. Indocyanine green (ICG), a near-infrared (NIR) photosensitizer, has been used in PDT for cancers. An extracorporeal light source may be used for shallow tissue because of the better tissue penetration of NIR light. The aim of this study was to evaluate the effect of ICG-PDT using extracorporeal NIR light on the inhibition of intimal hyperplasia in balloon-injured carotid arteries. A balloon injury (BI) model was used to induce intimal hyperplasia of carotid artery. Sprague-Dawley rats were divided into control, BI, BI + 1 × PDT, and BI + 2 × PDT groups. The control group underwent a sham procedure. PDT was performed 7 days after BI. In the BI + 1 × PDT group, ICG was administered 1 h before light irradiation. External illumination with 780-nm light-emitting diode light at a fluence of 4 J/cm was applied. For the BI + 2 × PDT group, PDT was performed again at day 7, following the first PDT. Hematoxylin and eosin (H & E) staining was performed to assess vessel morphology. Arterial wall thickness was significantly larger in the BI group compared with the control group. ICG-PDT significantly reduced arterial wall thickness compared with the BI group. Repeated PDT further decreased arterial wall thickness to the level of the control group. These findings indicate a promising approach for the treatment of restenosis of carotid arteries.

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Modulation of cell adhesion, proliferation and differentiation on materials designed for body implants

Bačáková

Filová

Pařízek

et al. 2011

Biotechnology Advances

845

716

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Photodynamic Therapy Reduces Intimal Hyperplasia in Prosthetic Vascular Bypass Grafts in a Pig Model

Abstract: Adjuvant PDT, performed in an endovascular fashion, was a safe method to reduce prosthetic graftstenosis in a preclinical setting. This study underscores the clinical potential of PDT to inhibit the development of clinical bypass graftstenosis.

Cited by 6 publications

References 28 publications

Novel Insights into the Pathobiology of the Vascular Access – Do They Translate into Improved Care?

Novel Insights into the Pathobiology of the Vascular Access – Do They Translate into Improved Care?

Photodynamic therapy of balloon-injured rat carotid arteries using indocyanine green

Modulation of cell adhesion, proliferation and differentiation on materials designed for body implants

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