Photodynamic therapy: photosensitizers and nanostructures

Escudero, Alberto; Carrillo‐Carrión, Carolina; Castillejos, Ma Carmen; Romero-Ben, Elena; Rosales-Barrios, Christian; Khiar, Noureddine

doi:10.1039/d0qm00922a

Cited by 129 publications

(126 citation statements)

References 220 publications

(207 reference statements)

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“…PDT (Photodynamic Therapy) is a treatment used via a photosensitizer and a light source to selectively kill cancer cells through the localized production of singlet oxygen. 220,221 However, the depth of light penetration into the tissue remains an obstacle to this therapy. 222 It was in the 1970s that derivatives of the hematoporphyrin HpD (Hematoporphyrin Derivative) were more widely studied.…”

Section: Photodynamic Therapy (Pdt) Applicationsmentioning

confidence: 99%

Corroles at work: a small macrocycle for great applications

2022

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Section: Photodynamic Therapy (Pdt) Applicationsmentioning

confidence: 99%

Corroles at work: a small macrocycle for great applications

2022

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“…These have led to improved controlled photoreaction, with sufficient fluorescence and ROS production. Furthermore, these have boosted tumor preferential specificity and the formulation of biomodulation approaches, increasing treatment efficiency [72,73], consequently enhancing the overall PDD and PDT outcomes. The emergence of nanotechnology and nanomedicine have made significant achievements in the early diagnosis and treatment of various diseases, including cancer.…”

Section: Nanomedicine For Targeted Photodynamic Diagnosis and Photodynamic Therapymentioning

confidence: 99%

Targeted Photodynamic Diagnosis and Therapy for Esophageal Cancer: Potential Role of Functionalized Nanomedicine

Didamson

Abrahamse

2021

Pharmaceutics

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Esophageal cancer is often diagnosed at the late stage when cancer has already spread and is characterized by a poor prognosis. Therefore, early diagnosis is vital for a better and efficient treatment outcome. Upper endoscopy with biopsy is the standard diagnostic tool for esophageal cancer but is challenging to diagnose at its premalignant stage, while conventional treatments such as surgery, chemotherapy, and irradiation therapy, are challenging to eliminate the tumor. Photodynamic diagnosis (PDD) and therapy (PDT) modalities that employ photosensitizers (PSs) are emerging diagnostic and therapeutic strategies for esophageal cancer. However, some flaws associated with the classic PSs have limited their clinical applications. Functionalized nanomedicine has emerged as a potential drug delivery system to enhance PS drug biodistribution and cellular internalization. The conjugation of PSs with functionalized nanomedicine enables increased localization within esophageal cancer cells due to improved solubility and stability in blood circulation. This review highlights PS drugs used for PDD and PDT for esophageal cancer. In addition, it focuses on the various functionalized nanomedicine explored for esophageal cancer and their role in targeted PDD and PDT for diagnosis and treatment.

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“…In terms of being able to inject a large number of TiO 2 NMs into vessels that are endothelial cells (ECs) lined by one epithelial scalp and anticontainous membrane between vessel wall and blood, many biological properties of TiO 2 NMs, including magnetic detection and hyperthermia, require a great deal (Dedman et al., 2021 ; Escudero et al., 2021 ; Liang et al., 2021 ). The ECs is a modulative agent for blood flow and blood vessel sound, which contributes to inflammatory and immune response, coagulation, growth controls, extracellular matrix's formation, and ECs damage, activation, or impairment are characteristic of specific disease conditions, such as atherosclerosis, lack of semi-permeableness and thrombosis (Zhang et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Synergic fabrication of succimer coated titanium dioxide nanomaterials delivery for in vitro proliferation and in vivo examination on human aortic endothelial cells

Song

et al. 2021

Drug Delivery

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The probable nanotoxicity to human health and the environment is a significant challenge for the sustainable application of nanomaterials in medicine. The cytototoxical effect of succimer (meso-2,3-dimercaptosuccinic acid-DMSA) coated titanium dioxide (DMSA-TiO 2 ) with cultured human aortic endothelial cells (HAoECs) was assessed in this investigation. Our findings have shown that DMSA-TiO 2 can be accumulated in HAoECs and dispersed in a cytoplasm on the culture medium. DMSA-cytotoxicity TiO 2 effects were dose-responsive, and the concentrations were of little toxicity, and MTT stain testing showed that they had only 0.02 mg ml −1 . Meanwhile, the lactate dehydrogenase biomarker was not considerably more remarkable than the biomarker from untreated (control) cells (free DMSA-TiO 2 ). Though, also without any apparent signs of cell damage, the endocrine functions for prostacyclin I-2 and endothelin-1 and the urea transporter functions were modified. In addition, in vitro endothelial tube development has been shown that HAoECs could induce angiogenesis even with small amounts of DMSA-TiO 2 (0.01 and 0.02 mg ml −1 ). Further, we have examined the in vivo toxicity and biochemical parameter by animal model. Furthermore, in vivo assessments designated that the resulting DMSA-TiO 2 presented synergistic activities of angiogenesis activity. Overall, these findings show the cytotoxicity of DMSA-TiO 2 and could induce adverse effects on normal endothelial cells.

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Photodynamic therapy: photosensitizers and nanostructures

Abstract: The reaction of some structures to different external stimuli can be used with therapeutic purposes. In particular, in Photodynamic Therapy (PDT) a light-sensitive compound or structure, commonly named as photosensitizer...

Cited by 129 publications

References 220 publications

Corroles at work: a small macrocycle for great applications

Corroles at work: a small macrocycle for great applications

Targeted Photodynamic Diagnosis and Therapy for Esophageal Cancer: Potential Role of Functionalized Nanomedicine

Synergic fabrication of succimer coated titanium dioxide nanomaterials delivery for in vitro proliferation and in vivo examination on human aortic endothelial cells

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