Photodynamic therapy (PDT) to treat a chronic skin wound in a dog

Abstract

Photodynamic Therapy (PDT) is an emerging and promising therapeutic modality for treatment of a wide variety of malignant and nononcologic tumors, as well as in the treatment of infected skin ulcers. This study evaluated the effectiveness of the PDT to treat a chronic skin wound that had been already subjected to several clinical and surgical type treatments in a dog. The animal with an infected chronic skin wound with 8 cm diameter in the left leg received an injection of an aqueous solution of 1% methylene blue (MB) with 2% lidocaine into the lesion. After MB injection the wound was irradiated using a LED (LED-VET MMOptics®) with a wavelength between 600 and 700 nm, 2 cm diameter circular light beam, of 150 mW of power, light dose of 50 J/cm 2 . After 3 and 6 weeks PDT was repeated and the wound was re-evaluated. Complete healing was achieved 10 weeks after the first procedure.

The Therapeutic Effects of Oral Intake of Hydrogen Rich Water on Cutaneous Wound Healing in Dogs

“…Wound healing involves a series of mechanisms, such as inflammatory response and oxidative stress, which play vital roles in wound pathophysiology [3]. Numerous therapeutic approaches have been used in clinical treatments, including photodynamic therapy, far-infrared ray therapy, adipose tissue extraction therapy, and arginine-based materials therapy [4][5][6][7], along with various biomaterial platforms based on anti-inflammation therapy strategies [8].…”

The Effects of Hydrogen-Rich Water on Skin Wound Healing in Dogs

“…wound healing involves a series of mechanisms, such as in ammatory response, oxidative stress, etc., which play vital roles in wound pathophysiology [3]. Numerous therapeutic approaches have been applied in clinical treatments, including photodynamic therapy, farinfrared ray therapy, and adipose tissue extraction therapy [4][5][6].…”