Photodynamic Therapy (PDT) in the Treatment of Patients with Resistant Superficial Bladder Cancer: A Long Term Experience

Nseyo, Unyime O.; DeHaven, Jean I.; Dougherty, Thomas J.; Potter, William R.; Merrill, Daniel L.; Lundahl, Scott L.; Lamm, Donald L.

doi:10.1089/clm.1998.16.61

Cited by 140 publications

(78 citation statements)

References 18 publications

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“…Transitional cell carcinoma (TCC) of the bladder can efficiently be treated with this type of therapy because, with careful control of the light distribution, curative doses can reach all parts of the urothelium (5)(6)(7). This is of importance in problematic superficial tumors, which are often multifocal.…”

Section: Introductionmentioning

confidence: 99%

Enhancing the photodynamic effect of hypericin in human bladder transitional cell carcinoma spheroids by the use of the oxygen carrier, perfluorodecalin

Kamuhabwa¹,

Huygens²,

Roskams³

et al. 2006

Int J Oncol

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Abstract. In the present study, we evaluated the possibility of enhancing the photodynamic effect of hypericin in transitional cell carcinoma (TCC) spheroids by the use of the oxygen carrier, perfluorodecalin. Following incubation with hypericin, RT-112 TCC spheroids were irradiated in the presence or absence of perfluorodecalin, at light doses of 7 J/cm 2 or 28 J/ cm 2 , delivered at a fluence rate of 15 mW/cm 2 . The photodynamic therapy (PDT) efficacy was evaluated and apoptotic cells were visualized. The results show that, in the absence of perfluorodecalin, spheroidal TCC cells are inadequately sensitive to hypericin PDT. As was shown by fluorescence microscopy, this lack of activity was not due to insufficient photoactive concentrations of hypericin reaching the inner parts of the spheroids. Conversely, enhanced oxygenation of spheroids by perfluorodecalin led to a dramatic enhancement of hypericin PDT efficacy. The detection of nuclear shrinkage or fragmentation with DAPI staining and the assessment of cell morphology by light microscopy indicated that apoptosis was the most prominent response of spheroids to hypericin PDT in the presence of perfluorodecalin. In conclusion, the results of this study suggest that perfluorocarbons, such as perfluorodecalin, are useful in enhancing the oxygenation of tumor tissue, resulting in highly efficient hypericin PDT. Since hypericin becomes concentrated specifically in human bladder urothelial carcinoma lesions and the bladder is very well suited to instillation with a perfluorocarbon, combining the techniques looks very promising for an efficient and selective whole bladder wall photodynamic antitumoral treatment in a urological clinical setting.

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Section: Introductionmentioning

confidence: 99%

Enhancing the photodynamic effect of hypericin in human bladder transitional cell carcinoma spheroids by the use of the oxygen carrier, perfluorodecalin

Kamuhabwa¹,

Huygens²,

Roskams³

et al. 2006

Int J Oncol

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“…These complications were associated with excessive light doses and nonuniform light delivery in the early studies. Nseyo et al showed that, for standardized protocols using lower drug and light dose [53], or for illumination with less penetrating light of 514 nm, good tumor response rates could be achieved for superficial lesions without transmural bladder injury or treatment-related morbidity [54]. Whole-bladder PDT with green light and proper dosimetry remains an attractive treatment option for carcinoma in situ (CIS), although this has not been fully evaluated.…”

Section: Bladder Cancermentioning

confidence: 99%

Photodynamic Therapy in Oncology

Triesscheijn¹,

et al. 2006

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Photodynamic therapy (PDT) is increasingly being recognized as an attractive, alternative treatment modality for superficial cancer. Treatment consists of two relatively simple procedures: the administration of a photosensitive drug and illumination of the tumor to activate the drug. Efficacy is high for small superficial tumors and, except for temporary skin photosensitization, there are no long-term side effects if appropriate protocols are followed. Healing occurs with little or no scarring and the procedure can be repeated without cumulative toxicity. Considering the efficacy and lack of long-term toxicity of PDT, and the fact that the first treatment of cancer with PDT was done more than 100 years ago, one might expect that this treatment had already become an established therapy. However, PDT is currently offered in only a few selected centers, although it is slowly gaining acceptance as an alternative to conventional cancer therapies. Here, we show the developmental steps PDT underwent and summarize the current clinical applications. The data show that, when properly used, PDT is an effective alternative treatment option in oncology. The

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“…7 Additionally, PDT agents have the potential to act as multifunctional theranostic agents to achieve simultaneous monitoring and therapeutic capabilities during cancer treatment. 8,9 For these reasons, PDT has emerged as an important therapeutic option in the management of cancers, such as early lung cancer, 10 Barrett's esophagus, 11 bladder cancer, 12 head and neck cancers, 13 skin cancer, 14 and bronchial cancers. 15 The essential element for effective PDT is an ideal PS, the lack of which continues to be a major roadblock restricting the clinical utility of PDT as a first-line treatment option.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic therapy of tumors with pyropheophorbide-<em>a</em>-loaded polyethylene glycol–poly(lactic-<em>co</em>-glycolic acid) nanoparticles

Liu¹,

Zhao²,

Wang³

et al. 2016

IJN

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Photodynamic therapy (PDT) has many advantages in treating cancers, but the lack of ideal photosensitizers continues to be a major limitation restricting the clinical utility of PDT. This study aimed to overcome this obstacle by generating pyropheophorbide- a -loaded polyethylene glycol–poly(lactic- co -glycolic acid) nanoparticles (NPs) for efficient tumor-targeted PDT. The fabricated NPs were efficiently internalized in the mitochondrion by cancer cells, and they efficiently killed cancer cells in a dose-dependent manner when activated with light. Systemically delivered NPs were highly enriched in tumor sites, and completely ablated the tumors in a xenograft KB tumor mouse model when illuminated with 680 nm light (156 mW/cm 2 , 10 minutes). The results suggested that this tumor-specific NP-delivery system for pyropheophorbide- a has the potential to be used in tumor-targeted PDT.

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Photodynamic Therapy (PDT) in the Treatment of Patients with Resistant Superficial Bladder Cancer: A Long Term Experience

Abstract: PDT using 1.5 mg/kg of Photofrin and 15 J/cm2 of light (630 nm) should be considered a safe and effective treatment for refractory CIS or recurrent papillary TCC.

Cited by 140 publications

References 18 publications

Enhancing the photodynamic effect of hypericin in human bladder transitional cell carcinoma spheroids by the use of the oxygen carrier, perfluorodecalin

Enhancing the photodynamic effect of hypericin in human bladder transitional cell carcinoma spheroids by the use of the oxygen carrier, perfluorodecalin

Photodynamic Therapy in Oncology

Photodynamic therapy of tumors with pyropheophorbide-<em>a</em>-loaded polyethylene glycol–poly(lactic-<em>co</em>-glycolic acid) nanoparticles

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Photodynamic Therapy (PDT) in the Treatment of Patients with Resistant Superficial Bladder Cancer: A Long Term Experience

Abstract: PDT using 1.5 mg/kg of Photofrin and 15 J/cm2 of light (630 nm) should be considered a safe and effective treatment for refractory CIS or recurrent papillary TCC.

Cited by 140 publications

References 18 publications

Enhancing the photodynamic effect of hypericin in human bladder transitional cell carcinoma spheroids by the use of the oxygen carrier, perfluorodecalin

Enhancing the photodynamic effect of hypericin in human bladder transitional cell carcinoma spheroids by the use of the oxygen carrier, perfluorodecalin

Photodynamic Therapy in Oncology

Photodynamic therapy of tumors with pyropheophorbide-<em>a</em>-loaded polyethylene glycol&ndash;poly(lactic-<em>co</em>-glycolic acid) nanoparticles

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Product

Resources

About

Photodynamic therapy of tumors with pyropheophorbide-<em>a</em>-loaded polyethylene glycol–poly(lactic-<em>co</em>-glycolic acid) nanoparticles