Photodynamic Therapy (PDT) for the local administration of Hematoporphyrine Derivative (HpD) Using A Dispatch Catheter

Katoh, Tomitsugu; Tamura, Ken; Sasame, Atsuko; Nakajima, Hitoshi; Amemiya, Tadashi; Usui, Mikio; Rakue, Hiroyuki; Miyagi, Manabu; Naitoh, Yuuichi; Ibukiyama, Chiharu

doi:10.2530/jslsm1980.18.4_55

Cited by 2 publications

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“…It should be noted that because the Dispatch catheter that was used as the local delivery catheter in this study delivers the drug spirally into the arterial walls, some luminal sections corresponding to the spirals of this catheter may not receive the drug. The experimental study of PDT in rabbits which used a Dispatch catheter [14,15] did not show a non-uniform effect on the vessels; however, using a local delivery catheter which can deliver drug more uniformly may be preferable.…”

Section: Local Administration Of Photosensitizermentioning

confidence: 99%

A first trial in the clinical application of photodynamic therapy for the prevention of restenosis after coronary‐stent placement

et al. 2004

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Section: Local Administration Of Photosensitizermentioning

confidence: 99%

A first trial in the clinical application of photodynamic therapy for the prevention of restenosis after coronary‐stent placement

et al. 2004

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“…We previously reported that administration of HpD in a very small amount using a dispatch catheter allows the local accumulation of significant amounts of HpD in the arteriosclerotic intima when compared with systemic administration. 24 Because HpD exhibits red-orange fluorescence with peaks at 630 nm and 690 nm in response to ultraviolet irradiation, it can be differentiated from autofluorescence more clearly, but intense light hypersensitivity occurs following systemic administration. Using these catheters, low-dose local administration of substances such as HpD, which shows excellent photosensitivity but cannot be administered systemically due to light hypersensitivity, may be possible and this method may have wider application.…”

Section: Fluorescence Spectral Analysis Of Arteriosclerotic Lesions Umentioning

confidence: 99%

Fluorescence Spectrum Analysis of Atherosclerotic Plaque Using Doxycycline

et al. 1999

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arious interventional therapies are presently used in the treatment of ischemic heart disease. In clinical trials in the US, percutaneous transluminal laser coronary angioplasty (PTLCA) was performed on 3,000 patients and 3,592 lesions using excimer laser, with a reported success rate of 84%. 1 When this method is compared with percutaneous transluminal coronary angioplasty (PTCA) using a balloon, PTLCA can be performed on diffuse lesions in which PTCA is difficult, and it may be possible to use the laser to recanalize a chronic total occlusion, a lesion in which the passage of a guide wire would be very difficult. In addition, PTCA is contraindicated in ostial stenosis, and PTLCA is considered the first choice in closed chest treatment. In PTLCA, however, unexpected coronary perforation occurs in between 1.2 to 2.4% of cases, 1-4 a rate which is obviously higher than for PTCA. As avoidance of coronary perforation is the paramount consideration in PTLCA, the requirement is for an appropriate guidance system to show the condition of the hypertrophic intima and the degree of ablation in real time, so that the atheroma alone is selectively ablated and the tunica media not irradiated.At present, evaluation of coronary arteriosclerotic lesions is made using angioscopy and intravascular ultrasound, neither of which can be inserted into the coronary artery at the same time as the laser irradiation system and so cannot be the appropriate guidance system. Fluorescence spectrum analysis is a method by which the fluorescence induced by irradiation at specific wavelengths of an arteriosclerotic lesion is examined in detail to make the diagno-

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Photodynamic Therapy (PDT) for the local administration of Hematoporphyrine Derivative (HpD) Using A Dispatch Catheter

Cited by 2 publications

References 0 publications

A first trial in the clinical application of photodynamic therapy for the prevention of restenosis after coronary‐stent placement

A first trial in the clinical application of photodynamic therapy for the prevention of restenosis after coronary‐stent placement

Fluorescence Spectrum Analysis of Atherosclerotic Plaque Using Doxycycline

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