Photodynamic Therapy (PDT) for Lung Cancers

Usuda, Jitsuo; Kato, Harubumi; Okunaka, Tetsuya; Furukawa, Kinya; Tsutsui, Hidemitsu; Yamada, Kimito; Suga, Yasuhiro; Honda, Hiroaki; Nagatsuka, Yoshitaka; Ohira, Tetsuya; Tsuboi, Masahiro; Hirano, Takashi

doi:10.1097/01243894-200606000-00018

Cited by 135 publications

(125 citation statements)

References 35 publications

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“…10 Therefore, we evaluated a new and effective photosensitizer, mono-L-aspartyl chlorin e6 (talaporfin sodium; NPe6, Laserphyrin ® ), which has been used for treating malignant tumors, such as bronchial cancer. [11][12][13] The 664 nm semiconductor laser light activates talaporfin sodium and penetrates into deep tissue to a depth of more than 10 mm. 14 Furthermore, laserphyrin-PDT (L-PDT) has a lower skin phototoxicity compared with photofrin-PDT (P-PDT) because talaporfin sodium degrades rapidly in vivo.…”

Section: Introductionmentioning

confidence: 99%

Synergic effect of photodynamic therapy using talaporfin sodium with conventional anticancer chemotherapy for the treatment of bile duct carcinoma

Nonaka¹,

Nanashima²,

Nonaka³

et al. 2013

Journal of Surgical Research

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Section: Introductionmentioning

confidence: 99%

Synergic effect of photodynamic therapy using talaporfin sodium with conventional anticancer chemotherapy for the treatment of bile duct carcinoma

Nonaka¹,

Nanashima²,

Nonaka³

et al. 2013

Journal of Surgical Research

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“…The thickened type is characterized by superficial lesions manifested by subtle mucosal changes on the bronchial surface, and it is the predominant type (14)(15)(16)(17). Of the 16 lesions examined in this study, 11 of them were the thickened type, 4 lesions were nodular type and 1 was the polypoid type.…”

Section: Patients' Characteristicsmentioning

confidence: 99%

“…The Japanese Lung Cancer Society classifies CLELCs on the basis of the endoscopic findings into a thickened type, polypoid type, and nodular type (14)(15)(16)(17). The thickened type is characterized by superficial lesions manifested by subtle mucosal changes on the bronchial surface, and it is the predominant type (14)(15)(16)(17).…”

Section: Patients' Characteristicsmentioning

confidence: 99%

Follow-up using fluorescence bronchoscopy for the patients with photodynamic therapy treated early lung cancer

et al. 2011

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“…The PS is excited by a specific wavelength of light and reacts with surrounding substrates or oxygen to produce reactive oxygen species (ROS) that damages tissues where the PS is localized [4]. Unlike an anticancer drug, the PS alone exhibits no severe cell toxicity [5], and low power light irradiation allows patients to obtain therapeutic efficacy after repeated treatment [6]. These characteristics of drugs and laser irradiation suggest that PDT is a potential treatment for drug-resistant prostate cancer [7] [8] [9].…”

Section: Introductionmentioning

confidence: 99%

Highly Selective Photodynamic Therapy with a Short Drug-Light Interval Using a Cytotoxic Photosensitizer Porphyrus Envelope for Drug-Resistant Prostate Cancer Cells

Hong¹,

Inai²,

Honda³

et al. 2018

IJCM

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Background: Photodynamic therapy (PDT) is a less invasive cancer treatment using photochemical reactions induced by light irradiation to a photosensitizer (PS). Highly selective PDT with fast accumulation of the PS in target site might be a promising treatment option for drug-resistant prostate cancer facing high incidence rate of elderly men who have no effective treatment options and require a minimally invasive treatment. Hemagglutinating virus of Japan envelope (HVJ-E) allows selective and fast drug delivery to the drugresistant prostate cancer cells via rapid cell membrane fusion. PS named porphyrus envelope (PE) has been developed by insertion of lipidated protoporphyrin IX (PpIX lipid) into HVJ-E. In this study, we investigated the optimal conditions for PE preparation and laser irradiation for highly selective PDT using PE with a short drug-light interval. Materials and Methods: Human hormon refractory prostate cancer cell line PC-3 and human normal prostate epithelial cell line PNT2 were cultured. PpIX lipid uptake and cytotoxicity of PDT in the cells incubated with PE for 10 min were evaluated by measuring fluorescence intensity and by using a cell counting reagent 24 h after PDT, respectively. Results: PpIX lipid uptake and cytotoxicity of PDT were increased with PpIX lipid concentration. Cytotoxicity of PDT using PE was more than 9 times as strong as that with PpIX lipid and PpIX induced by 5-aminolevulinic acid. Much stronger cytotoxicity was induced in PC-3 cells than PNT2 cells with the ratio of cell death rate for cancer to normal cells up to 4.64 ± 0.09. Conclusions: Fast PS delivery with HVJ-E allows highly selective PDT with a short drug-light interval. Therefore, PDT using PE has a potential to shorten treatment period and reduce side effects of PDT.

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Photodynamic Therapy (PDT) for Lung Cancers

Cited by 135 publications

References 35 publications

Synergic effect of photodynamic therapy using talaporfin sodium with conventional anticancer chemotherapy for the treatment of bile duct carcinoma

Synergic effect of photodynamic therapy using talaporfin sodium with conventional anticancer chemotherapy for the treatment of bile duct carcinoma

Follow-up using fluorescence bronchoscopy for the patients with photodynamic therapy treated early lung cancer

Highly Selective Photodynamic Therapy with a Short Drug-Light Interval Using a Cytotoxic Photosensitizer Porphyrus Envelope for Drug-Resistant Prostate Cancer Cells

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