Photodynamic therapy (PDT) for lung cancer

Allison, Ron R.; Moghissi, K.; Downie, Gordon; Dixon, Kate

doi:10.1016/j.pdpdt.2011.03.342

Cited by 120 publications

(77 citation statements)

References 50 publications

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“…For this reason, the photosensitizer is irradiated with light in an appropriate wavelength generated by precise sources, e.g., diode lasers or, considering the relatively high cost of lasers, the much cheaper, and portable light emitting diodes (LED). Fiber optics, or LED portable arrays illuminating light, are used for various types of cancer, including pulmonary tumors and fit through a bronchoscope or CT-guided needle or catheters [15]. A very important problem to be addressed is the suitable drug-light interval: as the photosensitizer is introduced into the body, and the vascular supply circulates as long as it accumulates in the tumor.…”

Section: Photodynamic Reactionmentioning

confidence: 99%

“…There is also another type of photodynamic therapy mechanism called the type III PDT mechanism. However, it is based on the direct interaction of excited photosensitizers, which is toxic to the target cancer cells without oxygen species being involved [12,15,17].…”

Section: Photomedicine -Advances In Clinical Practicementioning

confidence: 99%

“…Generally, clinicians and chemists have different views concerning the ideal photosensitizer. Chemists put more stress on a high extinction coefficient and a high quantum yield of singlet oxygen, whereas clinicians emphasize low toxicity and high selectivity [3,15,17,20,21].…”

Section: Modern Photosensitizers-drugs-applied In Therapy Nowadaysmentioning

confidence: 99%

“…It was found that this photosensitizer was evident to a certain degree in all tissues for 4-8 weeks post infusion due to a long clearance time. It possesses wide applications in PDT, e.g., in the early and late stages of lung cancer, superficial and advanced esophageal cancer, bladder cancer, cervical dysplasia and early stage cervical cancer, cancers of head and neck, brain, and skin [15,17,22,23]. However, this photosensitizer has many crucial defects.…”

Section: Modern Photosensitizers-drugs-applied In Therapy Nowadaysmentioning

confidence: 99%

“…Its sunlight photosensitivity skin reaction is in fact 2-3 weeks, but it is activated 4 h post infusion, which enables the convenient treatment in a single one day session. It possesses potential in ophthalmic lesions [11,15,20]. In the case of Verteporfin (Visudyne®) 2, the accumulation and elimination times are 20 times shorter than that of Foscan®.…”

Section: Modern Photosensitizers-drugs-applied In Therapy Nowadaysmentioning

confidence: 99%

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Nurses and Pharmacists in Interdisciplinary Team of Health Care Providers in Photodynamic Therapy

Kocki¹,

Czarczyńska-Goślińska²,

Kocka³

et al. 2017

Photomedicine - Advances in Clinical Practice

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Background: The modern treatment is based on wide cooperation between diverse representatives of medical professions. The photodynamic therapy is a noninvasive method of treatment both neoplastic diseases and miscellaneous noncancerous illnesses. It is complementary and competitive in some way to various traditional treatment techniques, including chemotherapy, radiotherapy, and surgery. This review emphasizes the significance of collaboration between specialists engaged in research, development, and practical use of photodynamic therapy.Methods: A literature search of electronic bibliographic databases and scientific publishers was performed. The relevant literature was analyzed to identify articles on the involvement of nurses, pharmacists, physicians, and other representatives in photodynamic therapy treatment.Results: In the photodynamic therapy, the overall success is not only dependent of a single unit. Coordinated actions of representatives possessing expertise in various fields of medical, and natural sciences are necessary both during joint research, development, and during the course of the photodynamic therapy treatment in clinics. Conclusions:The effective interaction between professionals and the division of responsibilities at different stages of therapy can guarantee the successful treatment. During therapy, the most important role belongs to the patient who is responsible for acting in accordance with schedules elaborated by physicians, nurses, and pharmacists.

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Section: Photodynamic Reactionmentioning

confidence: 99%

Section: Photomedicine -Advances In Clinical Practicementioning

confidence: 99%

Section: Modern Photosensitizers-drugs-applied In Therapy Nowadaysmentioning

confidence: 99%

Section: Modern Photosensitizers-drugs-applied In Therapy Nowadaysmentioning

confidence: 99%

Section: Modern Photosensitizers-drugs-applied In Therapy Nowadaysmentioning

confidence: 99%

See 3 more Smart Citations

Nurses and Pharmacists in Interdisciplinary Team of Health Care Providers in Photodynamic Therapy

Kocki¹,

Czarczyńska-Goślińska²,

Kocka³

et al. 2017

Photomedicine - Advances in Clinical Practice

View full text Add to dashboard Cite

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Photosensitizers for Two‐Photon Excited Photodynamic Therapy

Sun

Zhang

et al. 2017

Adv Funct Materials

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Photodynamic therapy (PDT) is a noninvasive protocol for the treatment of various cancers and nonmalignant diseases. Light, oxygen, and photosensitizer (PS) are the essential three elements in a typical PDT process. Currently, there are two major barriers limiting the further development of PDT. One issue is limited tissue penetration, and the other is the lack of high-performance PSs. Therefore, the newly emerging two-photon excited PDT (2PE-PDT) has attracted considerable attention in recent years due to its advantages such as a higher spatial resolution and a greater penetration depth. In this review, focus is on (i) the principle of 2PE-PDT, (ii) the progression of PSs for 2PE-PDT, and (iii) the potential indications and future directions in this field.

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Microbial‐Enabled Photosynthetic Oxygenation for Disease Treatment

Yang,

Li,

Feng

et al. 2023

Adv Funct Materials

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Oxygen as one of the most critical substances in living organisms has attracted ever‐increasing attention in disease treatment, which is important in regulating metabolic activities. However, the hypoxia arising from disease is a prevalent problem, leading to observably reduced therapeutic effectiveness in photodynamic therapy, radiotherapy, sonodynamic therapy, etc. Therefore, the reversion of hypoxia becomes the basis for enhancing the disease treatment. Thanks to the development of nanotechnology, various nanomaterials with oxygen‐production capacity are explored to recover the function of oxygen in tissue, but there are still some limitations. The photosynthetic microorganisms (PSMs) are extensively applied for improving hypoxia in diseases due to their highly efficient photocatalytic oxygen production efficacy and desirable biocompatibility. In this review, the up‐to‐date research progress on therapeutic modalities of microbial‐based photosynthetic oxygenation (e.g., cancer treatment, wound healing, and tissue engineering) are summarized and highlighted. In addition, the key issue of biocompatibility/biosafety of microbial‐based treatment that is fundamental to apply in vivo is further emphasized and clarified. Finally, the present critical issues are discussed and the future evolution of microbial‐based treatment based on photosynthetic oxygenation is predicted, promoting further development and clinical applications.

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Photodynamic therapy (PDT) for lung cancer

Cited by 120 publications

References 50 publications

Nurses and Pharmacists in Interdisciplinary Team of Health Care Providers in Photodynamic Therapy

Nurses and Pharmacists in Interdisciplinary Team of Health Care Providers in Photodynamic Therapy

Photosensitizers for Two‐Photon Excited Photodynamic Therapy

Microbial‐Enabled Photosynthetic Oxygenation for Disease Treatment

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