Photodynamic therapy outcome for oral dysplasia

Jerjes, Waseem; Upile, Tahwinder; Hamdoon, Zaid; Mosse, Charles A.; Akram, Sarah; Hopper, Colin

doi:10.1002/lsm.21036

Cited by 76 publications

(99 citation statements)

References 11 publications

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“…Two studies [19,20] reported the frequency of smoking. In the study by Jerjes et al [20], 49 individuals smoked less than 20 daily and 38 patients smoked more than 20 cigarettes per day. In the study by Pietruska et al [19], all smokers (n = 6) smoked less than 10 cigarettes daily.…”

Section: General Characteristics Of the Studiesmentioning

confidence: 98%

“…In 9 studies [15][16][17][18][19][20][22][23][24], smokers (ranging between 5 and 87 individuals) were included. Two studies [19,20] reported the frequency of smoking.…”

Section: General Characteristics Of the Studiesmentioning

confidence: 99%

“…Twenty-three studies, which did not fulfill the eligibility criteria, were excluded (Appendix A). In total, 13 studies [9,[15][16][17][18][19][20][21][22][23][24][25][26] were included and processed for data extraction. The pattern of the present study was customized to mainly summarize the relevant information.…”

Section: Search Strategymentioning

confidence: 99%

“…The total number of subjects ranged between 5 patients and 147 individuals. Seven studies [9,15,16,[20][21][22][23] reported the mean age of study participants, which was between 51 years and 62.2 years (age range 30-98 years). Nine studies [9,15,16,[18][19][20][21][22][23] reported the gender of subjects, in which the number of female participants ranged between 0 and 65 individuals.…”

Section: General Characteristics Of the Studiesmentioning

confidence: 99%

See 3 more Smart Citations

Efficacy of photodynamic therapy in the management of oral premalignant lesions. A systematic review

Vohra

Al-Kheraif

Qadri

et al. 2015

Photodiagnosis and Photodynamic Therapy

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Section: General Characteristics Of the Studiesmentioning

confidence: 98%

“…In 9 studies [15][16][17][18][19][20][22][23][24], smokers (ranging between 5 and 87 individuals) were included. Two studies [19,20] reported the frequency of smoking.…”

Section: General Characteristics Of the Studiesmentioning

confidence: 99%

Section: Search Strategymentioning

confidence: 99%

Section: General Characteristics Of the Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy of photodynamic therapy in the management of oral premalignant lesions. A systematic review

Vohra

Al-Kheraif

Qadri

et al. 2015

Photodiagnosis and Photodynamic Therapy

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“…Trabalhos clínicos recentes têm demonstrado que a PDT pode se constituir uma alternativa viável para o tratamento de CEC bucal. A PDT mediada pelo 5-ALA tem sido usado no tratamento de lesões potencialmente malignas (Chen et al, 2005;Tsai et al, 2004) e CEC bucal pouco invasivos Fan et al, 1996) com resultados clínicos promissores (Biel, 2007;Jerjes et al, 2011a). Quando comparada às terapias convencionais (cirurgia, radio e quimioterapia), a PDT tem como vantagem o fato de ser uma técnica minimamente invasiva, que leva à destruição do tumor com preservação do tecido sadio.…”

Section: Terapia Fotodinâmica E Cec Bucalunclassified

Resistência de células de carcinoma epidermóide bucal à terapia fotodinâmica mediada pelo ácido 5-aminolevulínico

Rosin¹

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A minha Orientadora, Prof a . Dr a . Luciana Corrêa, por sempre ouvir e discutir comigo todas as questões e dúvidas que surgiram durante o desenvolvimento desta tese e por ser essa pessoa tão generosa, inteligente e acessível. Admiro-a muito como pessoa e pesquisadora.Ao Prof. Dr. Moacir Novelli, que durante suas visitas ao laboratório sempre alegrava meu dia e por compartilhar comigo um pouco da sua imensa sabedoria. A Marina, a única companheira de profissão da Pós, que sempre esteve disposta a me ajudar e me ouvir, pela amizade, carinho e companheirismo. Pelos nossos cafés da manhã que sempre tornava meu dia mais leve e agradável.A Karla, pelo bom humor constante que sempre alegrava meu dia, por sempre me ouvir, me apoiar e pelos nossos cafezinhos.A Gabriela, por sempre estar ao meu lado me dando força e apoio, pelos nossos almoços diários na copa do departamento que tornavam meu dia mais alegre e por todo carinho e amizade.A Lara, pela amizade e por todo carinho e apoio. Por ser essa pessoa tão agradável e acessível por sempre estar disposta a me ourvir. Tenho a impressão de ter sido uma criança brincando à beira-mar, divertindo-me em descobrir uma pedrinha mais lisa ou uma concha mais bonita que as outras, enquanto o imenso oceano da verdade continua misterioso diante de meus olhos". Oral squamous cell carcinoma (SCC) is a malignant tumor with high morbidity and mortality rates, and it is difficult to treat. Conventional treatment for oral SCCs includes surgery and radiotherapy that may be followed by chemotherapy. Although these treatments are widely used, they are ineffective against some resistant tumors. Isaac Newton RESUMOOncologic photodynamic therapy (PDT) has been used as an adjuvant treatment for oral SCCs, especially in less invasive cases that require tumor reduction before surgical resection. However, like conventional treatments, PDT can induce the occurrence of resistant cell populations such as cutaneous carcinomas and colon and breast adenocarcinomas. The hypothesis that oral SCCs develop resistance to PDThas not yet been tested. Therefore, the aims of this study were to investigate whether oral SCCs (SCC9) develop resistance to several cycles of 5-aminolevulinic acidmediated PDT (5-ALA-PDT) and to determine whether the expression of markers associated with cell survival (NFB, Bcl-2, iNOS, mTOR, and Akt) is altered during this process. An oral SCC (SCC9) cell line was used, which was subjected to the following conditions: 1) Control: cultured without any treatment; 2) ALA: incubated with 5-ALA (1 mM for 4 h); 3) LED: treated with LED light (630 nm, 5.86 J/cm 2 , 22.5 J, 150 mW, 150 s); and 4) PDT: treated with 5-ALA-PDT (with the protocols of the ALA and LED groups combined) generating a lethal dose of 90%. Initially, only one cycle of PDT was administered, and cell viability was determined in all groups 24, 48, 72, and 120 h after irradiation. Subsequently, the DNA fragmentation detection assay (TUNEL) and immunofluorescence analysis of the expression of proteins NFB, Bcl-2, iNOS, pmTOR, ...

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Photodynamic therapy in cancer treatment

Ferreira‐Strixino

Debefve

2015

Lasers in Dentistry

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Photodynamic therapy outcome for oral dysplasia

Abstract: 5-ALA-PDT and/or mTHPC-PDT offer an effective alternative treatment for oral potentially malignant disorders.

Cited by 76 publications

References 11 publications

Efficacy of photodynamic therapy in the management of oral premalignant lesions. A systematic review

Efficacy of photodynamic therapy in the management of oral premalignant lesions. A systematic review

Resistência de células de carcinoma epidermóide bucal à terapia fotodinâmica mediada pelo ácido 5-aminolevulínico

Photodynamic therapy in cancer treatment

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