Photodynamic Therapy of Pterygium With Verteporfin

Fossarello, Maurizio; Peiretti, Enrico; Zucca, Ignazio Alberto; Perra, Maria Teresa; Serra, A.

doi:10.1097/00003226-200405000-00004

Cited by 18 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In ophthalmology, photodynamic therapy (PDT) has found significant applications in the therapy of age‐related macular degeneration (1). Several other ophthalmic applications of PDT have also been proposed, exploring the biological effect of photodynamic interaction in several ophthalmic tissues (2–7). Contact transcleral photodynamic therapy of the ciliary body (CB‐PDT) is an application that takes advantage of the photochemical effect of the PDT at the level of the CB, aiming to reduce the intraocular pressure (IOP).…”

Section: Introductionmentioning

confidence: 99%

Contact Transcleral Ciliary Body Photodynamic Therapy with Verteporfin in Pigmented Rabbits: Effect of Repeated Treatments

Charisis

Naoumidi

Ginis

et al. 2010

Photochem & Photobiology

View full text Add to dashboard Cite

We studied the effect on the intraocular pressure (IOP) and the ciliary body (CB) morphology after four consecutive contact transcleral photodynamic treatments of the ciliary body (CB-PDT) with verteporfin in pigmented rabbits. Twenty-two pigmented rabbits underwent CB-PDT (study group), performed once (six rabbits) or repeated for up to four times (16 rabbits). Six additional rabbits received only laser treatment without photosensitizer administration (control group). CB-PDT was performed in one eye in rabbits of the study group, with the fellow eye serving as internal control. Verteporfin dosage was 1 mg kg(-1) as bolus injection and laser settings were 40 mW (600 microm core optical fiber) for 1.5 min per spot, for 10 spots. In repeated CB-PDT, treatments were performed in 4-day intervals. Daily IOP measurements were recorded. Histological studies were performed at selected time points. An IOP reduction, more sustained following repeated treatments, was detected in all treated eyes but not in fellow eyes or in the control group. On the average, the IOP was restored to pretreatment levels 4 days after the last treatment. No serious adverse events were observed and the CB architecture was intact at the end of the experiment. Repeated CB-PDT is safe and results in a short-term reduction of IOP. Induced CB alterations are reversible.

show abstract

Section: Introductionmentioning

confidence: 99%

Contact Transcleral Ciliary Body Photodynamic Therapy with Verteporfin in Pigmented Rabbits: Effect of Repeated Treatments

Charisis

Naoumidi

Ginis

et al. 2010

Photochem & Photobiology

View full text Add to dashboard Cite

show abstract

“…The frequency of pterygia and the apparition of recurrences justify the rising number of reports published in indexed journals (over 150 reports during the past 2 years). The great interest raised by this condition is demonstrated by the number of surgical approaches for pterygium,4 associated with antimetabolites, either topical,5 or subconjunctival,6 radiotherapy,7 conjunctival and limbal grafts,8 amniotic membrane transplantation and even photodynamic therapy 9…”

mentioning

confidence: 99%

Efficacy of mitomycin C associated with direct conjunctival closure and sliding conjunctival graft for pterygium surgery

Hoz¹,

Montero²,

Alió

et al. 2007

British Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Overexpression of LDL-R combined with excessive LDL may be attributed to the supplement of cholesterol for membrane synthesis which is associated with cellular proliferation. Moreover, the effectiveness of photodynamic therapy (PDT) with verteporfin for pterygium48 and corneal neovascularisation49 50 support the relation between cholesterol metabolism and the development of pterygium. Cellular uptake of verteporfin by means of LDL-R is necessary to achieve cytotoxic response to PDT.…”

Section: Discussionmentioning

confidence: 99%

High HDL-C and high LDL-C are risk factors of pterygium in a population-based cross-sectional study in Southern China: the Dongguan Eye Study

et al. 2022

View full text Add to dashboard Cite

ObjectivesTo investigate the relationship between serum lipids and pterygium in a large-scale rural population aged 40 years or older from Southern China.Study designThe Dongguan Eye Study was a cross-sectional population-based study from September 2011 to February 2012.SettingThe area was set in the rural area of Dongguan, Southern China.ParticipantsAdult rural population aged 40 or older.MethodsParticipants underwent physical, haematological and ophthalmic examinations.Primary and secondary outcome measuresThe frequency and risk factors of pterygium.ResultsA total of 11 357 participants were eligible for inclusion and 8952 (78.8%) participants were enrolled for the systemic and ophthalmic examinations. The prevalence of pterygium was 17.3% after adjusting the sex and age distribution, 22.0% in participants with hypercholesterolaemia (total cholesterol ≥6.22 mmol/L (240 mg/dL)) and 21.8% in those with low-density lipoprotein-cholesterol (LDL-C) ≥4.14 mmol/L (160 mg/dL), respectively. After adjusting for multiple confounding factors, higher level of high-density lipoprotein-cholesterol (HDL-C) (OR: 1.23, 95% CI: 1.06 to 1.41) and LDL-C (OR: 1.13, 95% CI: 1.06 to 1.20) were positively associated with the risk of pterygium. The ORs for HDL-C or LDL-C with pterygium were significantly greater in participants aged 40–49 years than those aged 50 years or above (P for interaction <0.001). Furthermore, increased HDL-C showed greater association with pterygium in normal body mass index (BMI) group compared with overweight group (P for interaction=0.002).ConclusionIncreased HDL-C and LDL-C are risk factors of pterygium, especially in people <50 years or those with normal BMI level. Strict control of HDL-C and LDL-C may be a new prevention method in reducing the risk of pterygium.

show abstract

Photodynamic Therapy of Pterygium With Verteporfin

Abstract: PDT with verteporfin is a safe procedure to arrest the growth of pterygia. It is indicated for patients with a low- or medium-grade pterygium that refuse a surgical approach; however, multiple sessions may be required.

Cited by 18 publications

References 13 publications

Contact Transcleral Ciliary Body Photodynamic Therapy with Verteporfin in Pigmented Rabbits: Effect of Repeated Treatments

Contact Transcleral Ciliary Body Photodynamic Therapy with Verteporfin in Pigmented Rabbits: Effect of Repeated Treatments

Efficacy of mitomycin C associated with direct conjunctival closure and sliding conjunctival graft for pterygium surgery

High HDL-C and high LDL-C are risk factors of pterygium in a population-based cross-sectional study in Southern China: the Dongguan Eye Study

Contact Info

Product

Resources

About