Photodynamic therapy of hepatocellular carcinoma using tetra-triethyleneoxysulfonyl zinc phthalocyanine as photosensitizer

Ogbodu, Racheal O.; Nitzsche, Bianca; Ma, Andi; Atílla, Devrim; Gürek, Ayşe Gül; Höpfner, Michael

doi:10.1016/j.jphotobiol.2020.111915

Cited by 25 publications

(14 citation statements)

References 32 publications

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“…Western blotting was performed as described previously [ 27 ]. In short, radioimmunoprecipitation assay (RIPA) buffer was used to lyse whole-cell extracts.…”

Section: Methodsmentioning

confidence: 99%

Novel Thienyl-Based Tyrosine Kinase Inhibitors for the Treatment of Hepatocellular Carcinoma

Biersack

Goehringer

et al. 2022

JPM

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New medical treatments are urgently needed for advanced hepatocellular carcinoma (HCC). Recently, we showed the anticancer effects of novel thiophene-based kinase inhibitors. In this study, we further characterized the antineoplastic effects and modes of action of the two most promising inhibitors, Thio-Iva and Thio-Dam, and compared their effects with the clinically relevant multi-kinase inhibitor, sorafenib, in HCC cells. Crystal violet staining and real-time cell growth monitoring showed pronounced antiproliferative effects in Huh-7 and SNU-449 cells with IC50 values in the (sub-)micromolar range. Long-term incubation experiments revealed the reduced clonogenicity of Thio-Iva and Thio-Dam-treated HCC cells. LDH-release tests excluded cytotoxicity as an unspecific mode of action of the inhibitors, while flow cytometry analysis revealed a dose-dependent and pronounced G2/M phase cell cycle arrest and cyclin B1 suppression. Additionally, mitochondria-driven apoptosis was observed through the cytosolic increase of reactive oxygen species, a concomitant PARP cleavage, and caspase-3 induction. Both compounds were found to effectively inhibit the capillary tube formation of endothelial EA.hy926 cells in vitro, pointing towards additional antiangiogenic effects. Antiangiogenic and antineoplastic effects were confirmed in vivo by CAM assays. In summary, the thienyl-acrylonitrile derivatives, Thio-Iva and Thio-Dam, exert significant antineoplastic and antiangiogenic effects in HCC cells.

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“…Western blotting was performed as described previously [ 27 ]. In short, radioimmunoprecipitation assay (RIPA) buffer was used to lyse whole-cell extracts.…”

Section: Methodsmentioning

confidence: 99%

Novel Thienyl-Based Tyrosine Kinase Inhibitors for the Treatment of Hepatocellular Carcinoma

Biersack

Goehringer

et al. 2022

JPM

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“…ZnPc is also used in PDT of HCC cells. It can inhibit mitogen-activated protein kinase and extracellular signal-regulated kinase pathways through PDT, and upregulate Bax and downregulate Bcl-2 to destroy cancer cells ( 77 ). Gold nanoparticles combined with photosensitizer can be used for PDT of liver cancer cells.…”

Section: Pdtmentioning

confidence: 99%

Photodynamic and Photothermal Therapy of Hepatocellular Carcinoma

2021

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Hepatocellular carcinoma (HCC) is the most common primary liver tumor. It is ranked the sixth most common neoplasm and the third most common cause of cancer mortality. At present, the most common treatment for HCC is surgery, but the 5-year recurrence rates are still high. Patients with early stage HCC with few nodules can be treated with resection or radiofrequency ablation (RFA); while for multinodular HCC, transarterial chemoembolization (TACE) has been the first-line treatment. In recent years, based on medical engineering cooperation, nanotechnology has been increasingly applied to the treatment of cancer. Photodynamic therapy and photothermal therapy are effective for cancer. This paper summarizes the latest progress of photodynamic therapy and photothermal therapy for HCC, with the aim of providing new ideas for the treatment of HCC.

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“…Therefore, many attempts have been made to increase the water solubility of phthalocyanine derivatives. The most straightforward approach is the conjugation of hydrophilic elements such as sulfo, [15][16][17][18][19] carboxyl, [19][20][21] amino, 22 ammonio, 20,[23][24][25][26] hydroxy, 27 guanidyl, 28,29 and morpholine groups, 30 as well as polyethylene glycol moieties [31][32][33][34][35][36][37] at peripheral and non-peripheral positions. This strategy also affords additional functionalities such as tumortargeting ligands, including carbohydrates [38][39][40][41][42] and peptides.…”

Section: Introductionmentioning

confidence: 99%

Effect of tertiary amino groups in the hydrophobic segment of an amphiphilic block copolymer on zinc phthalocyanine encapsulation and photodynamic activity

2022

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Photodynamic therapy of hepatocellular carcinoma using tetra-triethyleneoxysulfonyl zinc phthalocyanine as photosensitizer

Cited by 25 publications

References 32 publications

Novel Thienyl-Based Tyrosine Kinase Inhibitors for the Treatment of Hepatocellular Carcinoma

Novel Thienyl-Based Tyrosine Kinase Inhibitors for the Treatment of Hepatocellular Carcinoma

Photodynamic and Photothermal Therapy of Hepatocellular Carcinoma

Effect of tertiary amino groups in the hydrophobic segment of an amphiphilic block copolymer on zinc phthalocyanine encapsulation and photodynamic activity

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