Photodynamic Therapy of Experimental Subchoroidal Melanoma Using Chloroaluminum Sulfonated Phthalocyanine

Özler, Serdar A.

doi:10.1001/archopht.1992.01080160133051

Cited by 19 publications

(13 citation statements)

References 18 publications

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“…19 In 1989, Panagopoulos et al 139 evaluated PDT with chloroaluminum sulfonated phthalocyanine dye for the treatment of experimental iris melanoma in rabbit eyes and found that tumor growth was arrested. In 1992, Ozler et al 137 demonstrated in a hamster model that PDT is also useful for choroidal melanoma. They showed that a total light dose of 15 Jcm −2 or less resulted in no response, and complications appeared when light dose was in excess of 43 J/cm 2 .…”

Section: Choroidal Melanomamentioning

confidence: 99%

Clinical use of photodynamic therapy in ocular tumors

Çerman

Çekıç

2015

Survey of Ophthalmology

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Section: Choroidal Melanomamentioning

confidence: 99%

Clinical use of photodynamic therapy in ocular tumors

Çerman

Çekıç

2015

Survey of Ophthalmology

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“…Of these, 27 articles were included for the qualitative synthesis, with publication dates from 1970 to 2018. Of the selected studies, 19 used PDT as treatment, [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] six used radiotherapy [34][35][36][37][38][39] and two used laser. 40,41 No studies with surgical therapy that met the inclusion criteria were obtained.…”

Section: Resultsmentioning

confidence: 99%

“…The irradiation agents in radiotherapy studies and the lasers employed in laser therapy are also shown in Table 3. Outcome of tumour therapy were evaluated by various methods, including biomicroscopy exams, 17,20,21,24,26,27,30,31,33,40,41 angiographic examination [15][16][17][18][19][21][22][23][24][26][27][28]31,33,40,41 histological examination, [15][16][17][18][19][20][21][22][23][26][27][28]30,31,33,34,36,37,40,41 fundoscopy, 18,19,…”

Section: Resultsmentioning

confidence: 99%

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Evaluation of eye melanoma treatments in rabbits: A systematic review

et al. 2021

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Melanomas are the most common cancer of the eye in canines, felines and humans. The treatment approaches vary, since no gold standard exists. Therefore, this systematic review aimed to compare the treatment modalities in ocular melanoma in rabbits. Medline/PubMed, Cochrane Library, Web of Science and Embase were searched for articles published until 21 April 2021 in English, Portuguese or Spanish, reporting animal studies evaluating photodynamic therapy (PDT), laser, radiotherapy or surgical excision. Twenty-seven articles were included for the qualitative synthesis, with publication dates from 1970 to 2018. Of the selected studies, 19 used PDT, six used radiotherapy and two used laser as treatment. No studies regarding surgical therapy that met the inclusion criteria were obtained. The tumour therapy results were evaluated in a heterogeneous manner for different periods and various methods, including microscopy, angiographic, histological examination, fundoscopy, ultrasound exam and electroretinogram. The treatment modalities analysed successfully treated the ocular melanoma, with tumour necrosis being commonly observed. Despite the therapeutic efficacy shown, side effects have been reported for all the therapies. The studies showed high heterogeneity, and therefore, in the future, new studies should be carried out to increase knowledge about ocular melanoma treatment. The analysed therapies can be used successfully in the treatment of ocular melanoma, with more conservative options such as PDT presenting great potential.

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“…71,[74][75][76] However, in experimental studies, investigators have used second-generation photosensitizers such as chloroaluminum sulfonated phthalocyanine (CASPc) 2,3-naphthalocyanince and benzoporphyrin derivatives (now commercially available as Norvatis AG, Hettlingen, Switzerland) in treating animal models of choroidal melanoma. [77][78][79][80][81][82] Some of these studies have used the Greene hamster melanoma cell line, which is amelanotic. Because more than 90% of human ocular choroidal melanomas are pigmented, we have developed and used the pigmented choroidal melanoma animal model, 83 which involves implanting B16 F10-pigmented mouse melanoma cells into subchoroidal space of New Zealand albino rabbits.…”

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Future Laser Approaches in Melanoma Treatment

Kim¹,

Gragroudas²,

Young³

2006

International Ophthalmology Clinics

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Choroidal melanoma is the most common primary intraocular malignancy in adults. 1 Several methods, including enucleation, 2-6 plaque radiotherapy, 7-18 charged-particle therapy, 19-22 local resection, 6,22-24 laser photocoagulation, 6,25-28 and even observation 3,29,30 are recommended for treatment of choroidal melanoma. Historically, enucleation was the standard method of treatment; however, because the advantage of enucleation in increasing patient survival has been challenged and recently proved to be noncontributory, 7,31-35 other globe-sparing therapeutic options have been advanced. The most frequently used treatment option is ionizing radiotherapy-brachytherapy, external beam irradiation using charged particles, or focused photon approaches. 7-22 Although radiation is effective in arresting tumor growth, it has been associated with numerous side effects, including dry eye, keratitis, cataract, radiation retinopathy and papillopathy, vitreous hemorrhage, glaucoma, and scleral necrosis. 10,[36][37][38][39][40][41] Laser photocoagulation using xenon arc, argon laser, and krypton laser have been used for the treatment of selected small choroidal melanomas. 26,41,42 In one study, the effects of xenon arc and argon laser photocoagulation of small choroidal melanomas were evaluated. 25 Recurrent tumor growth occurred in 14% of xenon arc-treated patients and 69% of argon laser-treated patients. Twelve and a half percent of patients treated with argon laser died of metastatic disease. It was postulated that argon wavelength laser energy is absorbed primarily by retinal pigment epithelium, and relatively little energy is absorbed by deeper structures. 25,41 Because photocoagulation as a primary therapy has limited usefulness, it has mainly been reserved as a supplement to plaque radiotherapy or for treating small recurrent tumors after radiotherapy. In this chapter, we discuss the future laser approaches for treatment of choroidal melanomas.

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Photodynamic Therapy of Experimental Subchoroidal Melanoma Using Chloroaluminum Sulfonated Phthalocyanine

Cited by 19 publications

References 18 publications

Clinical use of photodynamic therapy in ocular tumors

Clinical use of photodynamic therapy in ocular tumors

Evaluation of eye melanoma treatments in rabbits: A systematic review

Future Laser Approaches in Melanoma Treatment

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