Photodynamic therapy of cutaneous T-cell lymphoma cell lines mediated by 5-aminolevulinic acid and derivatives

Vallecorsa, Pablo; Venosa, Gabriela Di; Gola, Gabriel; Sáenz, Daniel A.; Mamone, Leandro; MacRobert, Alexander J.; Ramírez, Javier A.; Casas, Adriana

doi:10.1016/j.jphotobiol.2021.112244

Cited by 8 publications

(11 citation statements)

References 40 publications

(44 reference statements)

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“…Primary cutaneous T-cell lymphomas (CTCL) are a heterogeneous group of malignant non-Hodgkin neoplasms derived from malignant T cells that traffic to the skin [ 4 ].…”

Section: Photodynamic Therapy and Primary Cutaneous T-cell Lymphomasmentioning

confidence: 99%

“…Among them, mycosis fungoides (MF) is the most frequent disease (almost 50% of all CTCL), with an annual incidence of 0.3–0.5 new cases per 100,000 inhabitants [ 4 ]. Other CTCL include Sézary syndrome, CD 30+ positive lymphomas (such as lymphomatoid papulosis and anaplastic large cell lymphoma), and the group of rare and often aggressive NK/T-cell lymphomas, such as subcutaneous panniculitis-like T-cell lymphoma and extranodal NK/T-cell lymphoma.…”

Section: Photodynamic Therapy and Primary Cutaneous T-cell Lymphomasmentioning

confidence: 99%

“…CTCL are usually treated with a multimodal approach. Topical corticosteroids, nitrogen mustard, carmustine, topical retinoids (bexarotene and tazarotene), local radiotherapy, surgical excision, phototherapy (UVB and PUVA), alone or in combination with systemic therapy (bexarotene, interferon, or methotrexate), and extracorporeal photochemotherapy are often used for the treatment of CTCL [ 4 ]. The selection of appropriate treatments for CTCL, in particular for MF, is fundamental and is based on the clinical stage at diagnosis and patient prognosis and comorbidities.…”

Section: Photodynamic Therapy and Primary Cutaneous T-cell Lymphomasmentioning

confidence: 99%

“…It was licensed for the treatment of AKs, BCC, and Bowen’s disease. Other ALA esters such as ALA hexyl ester (He-ALA) are rarely used [ 4 ]. Anyway, all these molecules are the precursors of the “true” endogenous photosensitizer protoporphyrin IX (PpIX), a fluorescent compound and the penultimate step of the heme pathway [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Other ALA esters such as ALA hexyl ester (He-ALA) are rarely used [ 4 ]. Anyway, all these molecules are the precursors of the “true” endogenous photosensitizer protoporphyrin IX (PpIX), a fluorescent compound and the penultimate step of the heme pathway [ 4 ]. The endogenous synthesis of PpIX is controlled by the regulation of the ALA synthetase enzyme and PpIX is then converted by protoporphyrin ferrochelatase in the heme.…”

Section: Introductionmentioning

confidence: 99%

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Photodynamic Therapy as an Effective Treatment for Cutaneous Lymphomas

et al. 2022

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Topical photodynamic therapy (PDT) is a non-invasive treatment modality frequently used in dermatology to treat superficial skin cancers but also some inflammatory or infectious dermatoses. PDT appears a more and more promising therapeutic option also for cutaneous lymphomas, either of T- or B-cell origin. It is a well-tolerated treatment and has excellent cosmetic outcomes, less side effects compared to other therapies (steroids, surgery, radiotherapy, and so on), no particular contraindications, and is easily repeatable in case of relapses. However, how PDT works in the treatment of cutaneous lymphoproliferative diseases is poorly understood and the literature data are still controversial. Further randomized, controlled clinical trials involving a greater number of patients and centers with a long follow-up are necessary to assess the efficacy of PDT and establish a unique standardized treatment protocol in relation to the lymphomatous disease and the type, thickness, and location of the lesions.

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“…Primary cutaneous T-cell lymphomas (CTCL) are a heterogeneous group of malignant non-Hodgkin neoplasms derived from malignant T cells that traffic to the skin [ 4 ].…”

Section: Photodynamic Therapy and Primary Cutaneous T-cell Lymphomasmentioning

confidence: 99%

Section: Photodynamic Therapy and Primary Cutaneous T-cell Lymphomasmentioning

confidence: 99%

Section: Photodynamic Therapy and Primary Cutaneous T-cell Lymphomasmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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