Photodynamic Therapy of Brain Diseases

Telnova, Valeria; Dubrovsky, Alexander; Terskov, Andrey; Tsven, Anna; Semyachkina-Glushkovskaya, Oxana; Tuchin, Valery V.

doi:10.1007/978-981-19-1352-5_8

Cited by 1 publication

(2 citation statements)

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“…It also induces oxidative stress in tumor tissues to cause cell apoptosis. 164 PDT drug delivery systems can achieve chemotherapy and PDT by adding redox-responsive ligands in the nanoparticles. In the work of Zhu et al, disulfide bonds and photosensitive aptamer AS1411 are added to the nanoparticles.…”

Section: L-dopamentioning

confidence: 99%

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Small Scale, Big Impact: Nanotechnology-Enhanced Drug Delivery for Brain Diseases

Miao,

Xia,

Zou

et al. 2024

Mol. Pharmaceutics

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Central nervous system (CNS) diseases, ranging from brain cancers to neurodegenerative disorders like dementia and acute conditions such as strokes, have been heavily burdening healthcare and have a direct impact on patient quality of life. A significant hurdle in developing effective treatments is the presence of the blood−brain barrier (BBB), a highly selective barrier that prevents most drugs from reaching the brain. The tight junctions and adherens junctions between the endothelial cells and various receptors expressed on the cells make the BBB form a nonfenestrated and highly selective structure that is crucial for brain homeostasis but complicates drug delivery. Nanotechnology offers a novel pathway to circumvent this barrier, with nanoparticles engineered to ferry drugs across the BBB, protect drugs from degradation, and deliver medications to the designated area. After years of development, nanoparticle optimization, including sizes, shapes, surface modifications, and targeting ligands, can enable nanomaterials tailored to specific brain drug delivery settings. Moreover, smart nano drug delivery systems can respond to endogenous and exogenous stimuli that control subsequent drug release. Here, we address the importance of the BBB in brain disease treatment, summarize different delivery routes for brain drug delivery, discuss the cutting-edge nanotechnology-based strategies for brain drug delivery, and further offer valuable insights into how these innovations in nanoparticle technology could revolutionize the treatment of CNS diseases, presenting a promising avenue for noninvasive, targeted therapeutic interventions.

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Section: L-dopamentioning

confidence: 99%

“…PDT is known to cause BBB disruption, which enables the penetration of drugs into the brain. It also induces oxidative stress in tumor tissues to cause cell apoptosis . PDT drug delivery systems can achieve chemotherapy and PDT by adding redox-responsive ligands in the nanoparticles.…”

Section: Nanotechnology-based Strategies For Brain Drug Deliverymentioning

confidence: 99%