Photodynamic Therapy in Medicine with Mixed‐Metal/Supramolecular Complexes

Bullock, Jimmie L.; Holder, Alvin A.

doi:10.1002/9783527695225.ch7

Cited by 1 publication

(1 citation statement)

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“…Based on the topic and PDT research as carried out by the late Professor Karen Brewer, it is fitting that the reader should read the following before proceeding to the selected metal centers that are utilized in PDT: the special Issue in Inorganic Chimica Acta on “Coordination Chemistry: Understanding the role of molecular and supramolecular design on the photophysical, biological, and electron transfer properties of transition metal complexes and their potential applications. Dedicated to the memory of Karen J. Brewer” (https://www.sciencedirect.com/journal/inorganica-chimica-acta/vol/454/suppl/C) and PDT chapters in the textbook entitled “Ruthenium Complexes: Photochemical and Biomedical Applications” (39‐41).…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Therapy of Inorganic Complexes for the Treatment of Cancer^†

Smith

Days

Alajroush

et al. 2021

Photochem & Photobiology

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Photodynamic therapy (PDT) is a medicinal tool that uses a photosensitizer and a light source to treat several conditions, including cancer. PDT uses reactive oxygen species such as cytotoxic singlet oxygen (1O2) to induce cell death in cancer cells. Chemotherapy has historically utilized the cytotoxic effects of many metals, especially transition metal complexes. However, chemotherapy is a systemic treatment so all cells in a patient’s body are exposed to the same cytotoxic effects. Transition metal complexes have also shown high cytotoxicity as PDT agents. PDT is a potential localized method for treating several cancer types by using inorganic complexes as photosensitizing agents. This review covers several in vitro and in vivo studies, as well as clinical trials that reported on the anticancer properties of inorganic pharmaceuticals used in PDT against different types of cancer.

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Section: Introductionmentioning

confidence: 99%