Photodynamic therapy for treatment subretinal neovascularization

Abstract

This work are devoted our experience with photodynamic therapy (PDT) with «Photosens»for patients with choroidal neovascularization (CNV). 18 patients with subfoveal CNV in age-related macular degeneration (AMD), 24 patients with subfoveal CNV in pathological myopia (PM) and 4 patients with subfoveal CNV associated with toxoplasmic retinochoroiditis were observed. CNV was 100% classic in all study patients. Standardized protocol refraction, visual acuity testing, ophthalmologic examinations, biomicroscopy, fluorescein angiography, and ultrasonography were performed before treatment and 1 month, 3 months, 6 months, and 1 year after treatment; were used to evaluate the results of photodynamic therapy with «Photosens» (0.02% solution of mixture sulfonated aluminium phtalocyanine 0.05 mg/kg, intravenously). A diode laser («Biospec», Inc, Moscow) was used operating in the range of 675 nm. Need for retreatment was based on fluorescein angiographic evidence of leakage at 3-month follow-up intervals.At 3, 6, 9 month 26 (56.5%) patients had significant improvement in the mean visual acuity. At the end of the 12-month minimal fluorescein leakage from choroidal neovascularization was seen in 12 (26.1%) patients and the mean visual acuity was slightly worse than 0.2 which was not statistically significant as compared with the baseline visual acuity. Patients with fluorescein leakage from CNV underwent repeated PDT with «Photosens». 3Dmode ultrasound shown the decreasing thickness of chorioretinal complex in CNV area.Photodynamic therapy with «Photosens» can safely reduce the risk of severe vision loss in patients with predominantly classic subfoveal choroidal neovascularization secondary to AMD, PM and toxoplasmic retinochoroiditis. Downloaded From: http://proceedings.spiedigitallibrary.org/ on 06/24/2016 Terms of Use: http://spiedigitallibrary.org/ss/TermsOfUse.aspx SPIE-OSA/ Vol. 6632 663212-5 Downloaded From: http://proceedings.spiedigitallibrary.org/ on 06/24/2016 Terms of Use: http://spiedigitallibrary.org/ss/TermsOfUse.aspx

Vinpocetine modulates metabolic activity and function during retinal ischemia

“…In peripheral tissues, vinpocetine is linked to regulation of blood circulation, prevention of stroke and atherosclerosis, and reduction of inflammation (6,10,22,28,61,62,79). In the eye, vinpocetine provides neuroprotection against macular degeneration, diabetic retinopathy, and visual impairment secondary to Meniere's disease (4,5,37,52,63,65).…”

“…In peripheral tissues, vinpocetine is linked to regulation of blood circulation, prevention of stroke and atherosclerosis, and reduction of inflammation (6,10,22,28,61,62,79). In the eye, vinpocetine provides neuroprotection against macular degeneration, diabetic retinopathy, and visual impairment secondary to Meniere's disease (4,5,37,52,63,65).Vinpocetine has consistently been shown to be protective in ischemic injury of many tissues, including the brain, liver, and retina (28,31,32,44,54,74). Vinpocetine may protect against ischemia via multiple mechanisms.…”