Photodynamic Therapy for the Treatment of Endoanal Condylomata Acuminata

Gattai, Riccardo; Torchia, Daniele; Salvini, Camilla; Magini, Beatrice; Comacchi, Claudio; Cappuccini, Alessio; Ruffino, Irene; Calzavara‐Pinton, Piergiacomo; Cappugi, Pietro

doi:10.1086/656920

Cited by 11 publications

(7 citation statements)

References 2 publications

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“…Notwithstanding, the laser therapy for the patient could not eradicate completely acuminate wart, the combining treatments with laser ablation are essential. Many of data show that the applications of other favorable safety profiles or agents are also effective for treatment and prevention of condyloma acuminate, such as podophyllotoxin and imiquimod [3,6,8], Autogenous vaccine [9], intraurethral instillation and 5-fluorouracil solution [3,10], Trichloroacetic acid [3], Chinese medicine Keyouling [11], salicylic acid and dinitrochlorobenzen [12], cidofovir [3,13], photodynamic therapy with topical 5-aminolevulinic acid [14], microwave therapy combined with interleukin-2 [15], and others.…”

Section: Discussionmentioning

confidence: 99%

Treatment for Condyloma Acuminatum with Graves’ disease

Tang¹,

Luo²

2016

SJMCR

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Abstract:A rare case of external genital condylomata acuminatum with Graves' disease was reported. The cauliflower warts were observed on glans penis and foreskin of a 40-year-old man, who had typical Graves' symptoms. After combining treatment of laser, intramuscular injection interferon, and orally administered Acyclovir or Tamciclovir tablets, Amoxicilline capsules or phenoxy mephyl penicillin potassium tablets, vitamin C and vitamin B1 of multiple courses (weeks), the condylomata acuminatum recurred, the warts grew again, and Graves' disease worsened. However, after integrated treatment of laser, orally administered transfer factor, antibiotics and vitamins of three courses, the patient recovered fully and Graves' symptoms alleviated. The venereal warts have not recurred within six months.

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Section: Discussionmentioning

confidence: 99%

Treatment for Condyloma Acuminatum with Graves’ disease

Tang¹,

Luo²

2016

SJMCR

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“…gel, cream, solution soaked in cotton ball) can be used for cervical lesions. For example, the polyethylenglycole (PEG) gel formulation of ALA has been applied to endoanal and endovaginal lesions (31,32). As expected, other ester derivatives of ALA ( e.g.…”

Section: Discussionmentioning

confidence: 99%

“…It can also be combined with conventional therapy, e.g. cryotherapy and CO 2 laser ablation (30,31). But the optimal sequential order of combination modality still needs to be determined in future study.…”

Section: Discussionmentioning

confidence: 99%

“…Cell genotyping was carried out using a cytometric bead array kit (Tellgen Life Science Corporation, Shanghai, China) according to manufacturer's instruction. The kit can detect a total of 26 HPV DNA subtypes, including 19 HR HPV (HPV16, 18,26,31,33,35,39,45,51,52,55,56,58,59, 61, 66, 68, 73 and 83) and 7 LR HPV (HPV6, 11, 40, 42, 44, 53 and 54). Briefly, the genomic DNA was extracted from collected cells and used as a template.…”

Section: Methodsmentioning

confidence: 99%

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Treatment of HPV Infection‐Associated Cervical Condylomata Acuminata with 5‐Aminolevulinic Acid‐Mediated Photodynamic Therapy^†

Wang

Zhang

Miao

et al. 2012

Photochem & Photobiology

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The aim of this study was to investigate the efficacy of 5-aminolaevulinic acid (ALA)-mediated photodynamic therapy (PDT) in treatment of human papillomavirus (HPV)-associated cervical condylomata. A total of 56 patients with cervical and external condylomata lesions were recruited for this open-label study. HPV genotyping of exfoliated cells collected from the cervix and external lesions was performed. Cervical lesions were treated with PDT by applying ALA gel (10%) to the surface of the cervix for 4 h followed by irradiating with a 635 nm laser at 100 J cm(-2). PDT was repeated at 2-week intervals if lesion and HPV infection remained. Patients were followed up for 6-24 months. Genotyping analysis revealed four HPV subtypes (HPV6, 11, 16 and 18). The overall complete remission rate of 1-4 sessions of treatments was 98.2% and the corresponding HPV clearance rate was 83.9%. Ten cases showed complete removal of cervical lesions and HPV infection after a single treatment. Recurrence rate was 3.6%. Adverse effects were minimal and no structural complications were reported. In conclusion, topical ALA PDT is safe and effective for eradicating cervical HPV infection and eliminating condylomata lesion. Its definitive role in treating cervical condylomata deserves further investigation.

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“…In recent years, ALA‐PDT treatment for CA has been conducted in China and abroad. The results showed that ALA‐PDT was an effective technique in the treatment for CA with a higher clearance rate of warts and lower recurrence rates . However, most of these studies were designed as nonrandomized trials or the sample size of each study was not large enough to draw definitive conclusions.…”

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confidence: 99%

5‐aminolevulinic acid‐based photodynamic therapy for the treatment of condylomata acuminata in Chinese patients: a meta‐analysis

Zhao

Hong

2013

Photoderm Photoimm Photomed

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Photodynamic Therapy for the Treatment of Endoanal Condylomata Acuminata

Cited by 11 publications

References 2 publications

Treatment for Condyloma Acuminatum with Graves’ disease

Treatment for Condyloma Acuminatum with Graves’ disease

Treatment of HPV Infection‐Associated Cervical Condylomata Acuminata with 5‐Aminolevulinic Acid‐Mediated Photodynamic Therapy^†

5‐aminolevulinic acid‐based photodynamic therapy for the treatment of condylomata acuminata in Chinese patients: a meta‐analysis

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Photodynamic Therapy for the Treatment of Endoanal Condylomata Acuminata

Cited by 11 publications

References 2 publications

Treatment for Condyloma Acuminatum with Graves’ disease

Treatment for Condyloma Acuminatum with Graves’ disease

Treatment of HPV Infection‐Associated Cervical Condylomata Acuminata with 5‐Aminolevulinic Acid‐Mediated Photodynamic Therapy†

5‐aminolevulinic acid‐based photodynamic therapy for the treatment of condylomata acuminata in Chinese patients: a meta‐analysis

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Treatment of HPV Infection‐Associated Cervical Condylomata Acuminata with 5‐Aminolevulinic Acid‐Mediated Photodynamic Therapy^†