Photodynamic therapy for superficial basal cell carcinomas: Clinical features of partial responses and recurrences

Condorelli, Alessandra Grazia; Motolese, Alfonso; Borgia, Francesco; Bartolomeo, Luca Di; Bianchi, Lodovico; Rossi, Paolo; Ottone, Marta; Guarneri, Fabrizio; Motolese, Alberico

doi:10.1016/j.pdpdt.2022.102727

Cited by 10 publications

(7 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After a predetermined incubation period and upon irradiation with red light (~630 nm), these prodrugs stimulate cytotoxic reactive oxygen species (ROS) production, selectively destroying cells with a high metabolic state, including infective, tumoral, and inflammatory ones [31]. PDT has been used successfully in the treatment of non-melanoma skin cancer and actinic keratoses, with growing experience in the management of infectious dermatoses; however, less evidence exists for the treatment of inflammatory diseases, including NL [59][60][61][62][63]. The literature shows variable results about the efficacy of PDT, with clearance rates that are often very different from each other, with great variability between the number of sessions and the interval between sessions.…”

Section: Discussionmentioning

confidence: 99%

Shedding Light on Photodynamic Therapy in the Treatment of Necrobiosis Lipoidica: A Multicenter Real-Life Experience

Li Pomi,

Motolese,

Paganelli

et al. 2024

IJMS

Self Cite

View full text Add to dashboard Cite

Necrobiosis Lipoidica (NL) is a dermatological condition characterized by the development of granulomatous inflammation leading to the degeneration of collagen and subsequent formation of yellowish-brown telangiectatic plaques usually localized on the pretibial skin of middle-aged females. Due to its rarity and unclear etiopathogenesis, therapeutic options for NL are not well-standardized. Among them, photodynamic therapy (PDT) is an emerging tool, although its efficacy has primarily been evaluated in single case reports or small case series. This study reports the real-life experience of a cohort of NL patients treated with PDT at the Section of Dermatology of the University Hospital of Messina and Reggio-Emilia. From 2013 to 2023, 17 patients were enrolled —5 males (29%) and 12 females (71%) aged between 16 and 56 years (mean age: 42 ± 13 years), with a median duration of NL of 8 years. The overall complete clearance (>75% lesion reduction) was 29%, while the partial clearance (25–75% lesion reduction) was 59%, with 12% being non-responders. This study adds to the little amount of evidence present in the literature regarding the effectiveness of PDT in the treatment of NL. Variability in treatment responses among patients underscores the need for personalized protocols, optimizing photosensitizers, light sources, and dosimetry. The standardization of treatment protocols and consensus guidelines are essential to ensure reproducibility and comparability across studies.

show abstract

Section: Discussionmentioning

confidence: 99%

Shedding Light on Photodynamic Therapy in the Treatment of Necrobiosis Lipoidica: A Multicenter Real-Life Experience

Li Pomi,

Motolese,

Paganelli

et al. 2024

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…A recent study in adult patients observed higher recurrence rates in BCCs of neck and head treated with MAL-PDT ( Condorelli et al, 2022 ). Vinciullo et al highlighted that lesions located in the H-zone, whether large or not, had unfavorable CCR following MAL-PDT ( Vinciullo et al, 2005 ).…”

Section: Pdt and Pediatric Skin Cancersmentioning

confidence: 99%

Photodynamic therapy in pediatric age: Current applications and future trends

et al. 2022

Self Cite

View full text Add to dashboard Cite

Photodynamic therapy (PDT) is a photochemotherapy based on local application of a photosensitive compound and subsequent exposure to a light source of adequate wavelength. It is a non-invasive therapeutic procedure widely used in oncodermatology for treatment of numerous skin cancers, but in the last years its use has been gradually extended to an increasing list of skin diseases of both infectious and inflammatory nature. Although PDT is proven as a safe and effective therapeutic option in adults, its use is not well standardized in the pediatric population. In this review, we will focus on clinical applications, mechanisms of action, protocols, and adverse events in children and adolescents. Most of pediatric experiences concerned treatment of skin cancers in Gorlin syndrome and xeroderma pigmentosum, acne vulgaris, and viral warts, but other applications emerged, such as cutaneous lymphoma and pseudo-lymphomas, necrobiosis lipoidica, hidradenitis suppurativa, dissecting cellulitis, leishmaniasis, angiofibromas, verrucous epidermal nevus, and linear porokeratosis. In these pediatric diseases, PDT appeared as an effective therapeutic alternative. The results on vitiligo were limited and not fully encouraging. Although highly versatile, PDT is not a therapy for all skin diseases, and a deeper knowledge of its mechanisms of action is required to better define its spectrum of action and safety in pediatric patients.

show abstract

“…One of the game changers deals with the progress of modern laser medicine and fundamentally new technologies are gradually being introduced into clinical practice. The effectiveness of tumor treatment using laser technology has been confirmed in many preclinical and clinical studies [2][3][4][5][6]. The study of lasers effects on biological objects, in particular targeted on improvement of therapeutic strategies to cancer treatment is in focus of researchers around the globe [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Cytomorphological Changes in McF7-Dox Cells and Their Correlation With the Activity of the Cell Cycle Regulator P21 After Combined Exposure to Infrared Laser and Doxorubicin

Konovalenko¹,

Protsenko²

2023

ArveMED

View full text Add to dashboard Cite

Introduction: In recent years, studies of infrared laser irradiation effect on tumor cells in combination with various chemotherapeutic agents have been developing dynamically. Objective: To study the effect of infrared laser in combination with low doses of doxorubicin on cytomorphological characteristics of MCF-7DOX culture cells and p21 expression level. Materials and Methods: MCF-7DOX tumor cells were cultured in DMEM medium with 10% fetal calf serum (FCT) and 40 μg/ml gentamicin. Doxorubicin was added to the cells to a final concentration of 2 μg/ml and 0.5 μg/ml. Cells were irradiated with infrared laser (Fotonika-Plus, Ukraine) with a wavelength of 810 nm (irradiation time — 5 min, power density — 50 mV/cm², irradiation dose 15 J/cm²). Photomicrographs of cells were taken using a Carl Zeiss microscope, Germany. An immunocytochemical study was also conducted using monoclonal antibodies to the factor p21 (Thermo Scientific, USA). Results: The evaluation of morphological characteristics in micropreparations testifies to the antitumor effectiveness of the combined effect of infrared laser irradiation and doxorubicin. It is noteworthy that the cytotoxic effects of chemotherapy in combination with photobiomodulation were observed when using different doses of doxorubicin: 2 μg/ml and 0.5 μg/ml. When studying the biological activity of cells using immunocytochemistry, it was established that the combination of doxorubicin and infrared laser irradiation led to an increase in the expression of p21, and it is important to note that a similar effect was observed at both concentrations of doxorubicin: as at 2.0 μg/ ml and 0.5 μg/ml. The simultaneous destructive effect on tumor cells and the increase in p21 expression allows us to make a preliminary cautious assumption that the proposed technique of combination of infrared laser irradiation with doxorubicin determines the effect of the p21 factor in the role of a tumor suppressor. Conclusions: The results of the study allow us to consider the use of doxorubicin in combination with infrared laser as a promising method of cytotoxic effect on tumor cells.

show abstract

Photodynamic therapy for superficial basal cell carcinomas: Clinical features of partial responses and recurrences

Cited by 10 publications

References 26 publications

Shedding Light on Photodynamic Therapy in the Treatment of Necrobiosis Lipoidica: A Multicenter Real-Life Experience

Shedding Light on Photodynamic Therapy in the Treatment of Necrobiosis Lipoidica: A Multicenter Real-Life Experience

Photodynamic therapy in pediatric age: Current applications and future trends

Cytomorphological Changes in McF7-Dox Cells and Their Correlation With the Activity of the Cell Cycle Regulator P21 After Combined Exposure to Infrared Laser and Doxorubicin

Contact Info

Product

Resources

About