Photodynamic therapy for malignant tumours of the ampulla of Vater.

Abulafi, A. M.; Allardice, J. T.; Williams, N. S.; Someren, Niall van; Swain, C. Paul; Ainley, Colin

doi:10.1136/gut.36.6.853

Cited by 52 publications

(17 citation statements)

References 17 publications

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“…In a pilot clinical trail, Bown et al [10] used PDT in the palliative treatment of 16 patients with cancers in the pancreatic head that could not be treated with surgery because of the advanced nature of the disease or the general condition of the patients, and they concluded that PDT may be of value for treating localized cancers in patients who are poor candidates for definitive surgery or in whom the location of tumor makes pancreatic resection inappropriate. Abulafi et al [29] and Tseng et al [30] reported that patients with pancreatic and ampullary carcinoma Xie Q et al . Gemcitabine and photodynamic therapy for pancreatic cancer who are not suitable for surgery should be treated with PDT, since PDT is both feasible and safe for small tumors.…”

Section: Discussionmentioning

confidence: 99%

Synergetic anticancer effect of combined gemcitabine and photodynamic therapy on pancreatic cancer in vivo

Xie¹,

Jia²,

Liu³

et al. 2009

WJG

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AIM:To investigate the anti-tumor effects of combined cytotoxic drug (gemcitabine) and photodynamic therapy (PDT) on human pancreatic cancer xenograft in nude mice. METHODS:Human pancreatic cancer cell line SW1990 was used in the investigation of the in vivo effect of combined gemcitabine and PDT on human pancreatic cancer xenograft in mice. Sixty mice were randomly allocated into a control group (without treatment), photosensitizer treatment group (2 mg/kg photosan, without illumination), chemotherapy group (50 mg/kg gemcitabine i.p.), PDT group (2 mg/kg photosan + laser irradiation) and combined treatment group (photosan + chemotherapy), with 12 mice in each group. Tumor size was measured twice every week. Anti-tumor activity in different groups was evaluated by tumor growth inhibition (TGI). RESULTS:No significant anti-tumor effect was observed either in photosensitizer treatment group or in chemotherapy group. PDT led to necrosis in cancer lesions and significantly reduced tumor volume compared with photosensitizer on day 6 and at the following time points after initialization of therapy (0.24 ± 0.15-0.49 ± 0.08 vs 0.43 ± 0.18-1.25 ± 0.09, P < 0.05). PDT significantly reduced tumor volume in combined treatment group compared with photosensitizer treatment group (0.12 ± 0.07-0.28 ± 0.12 vs 0.39 ± 0.15-1.20 ± 0.11, P < 0.05), small dose chemotherapy group (0.12 ± 0.07-0.28 ± 0.12 vs 0.32 ± 0.14-1.16 ± 0.08, P < 0.05) and control group (0.12 ± 0.07-0.28 ± 0.12 vs 0.43 ± 0.18-1.25 ± 0.09, P < 0.05). TGI was higher in the combined treatment group (82.42%) than in the PDT group (58.18%). CONCLUSION:PDT has a significant anti-tumor effect, which is maintained for a short time and can be significantly enhanced by small doses of gemcitabine.

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Section: Discussionmentioning

confidence: 99%

Synergetic anticancer effect of combined gemcitabine and photodynamic therapy on pancreatic cancer in vivo

Xie¹,

Jia²,

Liu³

et al. 2009

WJG

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“…However, the choice and timing of treatment remain a clinical challenge. A combined approach of endoscopic surveillance, with either endoscopic or surgical intervention, as necessitated by the type of lesion, has been shown to be successful during long term follow up of patients with FAP [10]. However, both endoscopic and surgical resection [11] of polyps have been plagued with recurrence of these lesions requiring continued surveillance.…”

Section: Introductionmentioning

confidence: 98%

Endoscopic Management of Duodenal Adenomas in Familial Adenomatous Polyposis—A Single-Center Experience

et al. 2011

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“…The human duodenum is much thicker than that in the hamster and is likely to be much more resistant to perforation. Two preliminary clinical reports using PDT with Photofrin to treat duodenal and ampullary tumours showed an encouraging response with no perforations (Abulafi et al, 1995;Mlkvy et al, 1995). This suggests that it is likely to be safe to treat lesions in the human pancreas.…”

Section: Discussionmentioning

confidence: 93%

Photodynamic therapy of a transplanted pancreatic cancer model using meta-tetrahydroxyphenylchlorin (mTHPC)

MIkvy

Messman²,

MacRobert³

et al. 1997

Br J Cancer

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Summary Pancreatic cancer is difficult to treat, even for tumours localized to the pancreas. Photodynamic therapy (PDT) is a non-thermal technique for producing localized tissue necrosis with light after prior administration of a photosensitizing drug and it could have a role in the local treatment of these cancers. We studied PDT in a transplanted cancer in the hamster pancreas using the photosensitizer mTHPC (metatetrahydroxyphenylchlorin). Fluorescence microscopy showed maximum levels of mTHPC in normal pancreas 2-4 days after sensitization and in tumour at 4-5 days. For PDT, animals were given 0.1 or 0.3 mg kg-' mTHPC and the tumour was treated at laparotomy 2 or 4 days later with red light (50 J at 650 nm, continuous or fractionated) delivered via a single fibre touching the tumour surface. The maximum zone of tumour necrosis (seen 3 days after PDT) was 8.7 mm in diameter with continuous irradiation, increasing to 12.4 mm with light fractionation (four equal fractions with 3 min between fractions). The main complication was sealed duodenal perforation, seen in 3 of 16 animals, probably due to inadequate shielding of the duodenum from the light. The duodenal problems seen in hamsters are unlikely to cause trouble in the much thicker human duodenum. PDT tumour necrosis in this animal model has now been shown with a range of photosensitizers, but mTHPC is attractive as it is likely to produce the largest volumes of necrosis around each treatment point with short light exposure times. This technique could have a role in the treatment of localized cancers of the pancreas in patients unsuitable for surgery and can now be considered for preliminary clinical trials.

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Photodynamic therapy for malignant tumours of the ampulla of Vater.

Abstract: (Gut 1995; 36: 853-856)

Cited by 52 publications

References 17 publications

Synergetic anticancer effect of combined gemcitabine and photodynamic therapy on pancreatic cancer in vivo

Synergetic anticancer effect of combined gemcitabine and photodynamic therapy on pancreatic cancer in vivo

Endoscopic Management of Duodenal Adenomas in Familial Adenomatous Polyposis—A Single-Center Experience

Photodynamic therapy of a transplanted pancreatic cancer model using meta-tetrahydroxyphenylchlorin (mTHPC)

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