Photodynamic therapy for leishmaniasis: Recent advances and future trends

Varzandeh, Mohammad; Mohammadinejad, Reza; Esmaeilzadeh-Salestani, Keyvan; Dehshahri, Ali; Zarrabi, Ali; Aghaei-Afshar, Abbas

doi:10.1016/j.pdpdt.2021.102609

Cited by 22 publications

(13 citation statements)

References 142 publications

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“…In type 2 PDT the excited PS interacts with surrounding molecular oxygen to form the extremely reactive singlet oxygen 272 . These ROS oxidizes biomolecules inside cells (lipids, proteins, and nucleic acids) or damages the plasma membrane, resulting in cell death 273–275 . PDT has been shown to deoxygenate and affect the physical properties of the tumor microenvironment 276 .…”

Section: Synergistic Effects Of Radiosensitizing Nps In Combination T...mentioning

confidence: 99%

Application of nano‐radiosensitizers in combination cancer therapy

Varzandeh

Sabouri

Mansouri

et al. 2023

Bioengineering & Transla Med

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Radiosensitizers are compounds or nanostructures, which can improve the efficiency of ionizing radiation to kill cells. Radiosensitization increases the susceptibility of cancer cells to radiation‐induced killing, while simultaneously reducing the potentially damaging effect on the cellular structure and function of the surrounding healthy tissues. Therefore, radiosensitizers are therapeutic agents used to boost the effectiveness of radiation treatment. The complexity and heterogeneity of cancer, and the multifactorial nature of its pathophysiology has led to many approaches to treatment. The effectiveness of each approach has been proven to some extent, but no definitive treatment to eradicate cancer has been discovered. The current review discusses a broad range of nano‐radiosensitizers, summarizing possible combinations of radiosensitizing NPs with several other types of cancer therapy options, focusing on the benefits and drawbacks, challenges, and future prospects.

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Section: Synergistic Effects Of Radiosensitizing Nps In Combination T...mentioning

confidence: 99%

Application of nano‐radiosensitizers in combination cancer therapy

Varzandeh

Sabouri

Mansouri

et al. 2023

Bioengineering & Transla Med

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“… 241 , 243 , 244 Liposomes have a wide diversity of applications in various disease treatments caused by viruses, bacteria, or protozoa. 245 , 246 Even though liposomes are the most widely used LNPs, 247 their therapeutic outcomes can be further improved with several surface modifications. 247 Both hydrophobic and hydrophilic drugs can successfully be loaded in liposomes, and DEX-loaded liposomes are well-established in preclinical studies ( Table 1 ).…”

Section: Dexamethasone Delivery Systemsmentioning

confidence: 99%

“…Liposomes are well-established lipid-based drug delivery systems. , Even though liposome discovery dates back to the 1980s, it has recently become more attractive following FDA approval of several liposomal-based therapeutics, and many are in clinical trials. , Among several types of nanoformulations, the liposomal-based drugs were approved by the FDA to treat various diseases, including cancer. ,, Liposomes have a wide diversity of applications in various disease treatments caused by viruses, bacteria, or protozoa. , Even though liposomes are the most widely used LNPs, their therapeutic outcomes can be further improved with several surface modifications . Both hydrophobic and hydrophilic drugs can successfully be loaded in liposomes, and DEX-loaded liposomes are well-established in preclinical studies (Table ).…”

Section: Dexamethasone Delivery Systemsmentioning

confidence: 99%

Dexamethasone: Insights into Pharmacological Aspects, Therapeutic Mechanisms, and Delivery Systems

Madamsetty

Mohammadinejad

Uzielienè

et al. 2022

ACS Biomater. Sci. Eng.

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Dexamethasone (DEX) has been widely used to treat a variety of diseases, including autoimmune diseases, allergies, ocular disorders, cancer, and, more recently, COVID-19. However, DEX usage is often restricted in the clinic due to its poor water solubility. When administered through a systemic route, it can elicit severe side effects, such as hypertension, peptic ulcers, hyperglycemia, and hydro-electrolytic disorders. There is currently much interest in developing efficient DEX-loaded nanoformulations that ameliorate adverse disease effects inhibiting advancements in scientific research. Various nanoparticles have been developed to selectively deliver drugs without destroying healthy cells or organs in recent years. In the present review, we have summarized some of the most attractive applications of DEX-loaded delivery systems, including liposomes, polymers, hydrogels, nanofibers, silica, calcium phosphate, and hydroxyapatite. This review provides our readers with a broad spectrum of nanomedicine approaches to deliver DEX safely.

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“…Later on, several scientists developed methods for high yield synthesis of curcumin which are in use today . Curcumin is the most widely used plant-based drug with various pharmacological benefits, including anti-inflammatory, antioxidant, anti-viral, anti-bacterial, anti-fungal, anti-parasite, and anti-cancer. − Numerous preclinical studies have proven curcumin to be effective in several cancers because of curcumin’s capability to induce G2/M cell cycle arrest, trigger apoptosis, induce autophagy, disturb molecular signaling, inhibit invasion and metastasis, and increase the efficiency of existing chemotherapeutics. , The inflammatory response of curcumin is often steered by the radical production of pro-inflammatory cytokines, including interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α). , Consequently, the downregulation of pro-inflammatory cytokines may effectively reduce the incidence of inflammation . Curcumin is also involved in other signaling pathways like it induces degranulation in human neutrophils by increasing the cell surface expression of clusters of differentiation 35 (CD35), CD66b, and CD63 .…”

Section: Introductionmentioning

confidence: 99%

Next-Generation Hydrogels as Biomaterials for Biomedical Applications: Exploring the Role of Curcumin

et al. 2023

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Since the first report on the pharmacological activity of curcumin in 1949, enormous amounts of research have reported diverse activities for this natural polyphenol found in the dietary spice turmeric. However, curcumin has not yet been used for human application as an approved drug. The clinical translation of curcumin has been hampered due to its low solubility and bioavailability. The improvement in bioavailability and solubility of curcumin can be achieved by its formulation using drug delivery systems. Hydrogels with their biocompatibility and low toxicity effects have shown a substantial impact on the successful formulation of hydrophobic drugs for human clinical trials. This review focuses on hydrogel-based delivery systems for curcumin and describes its applications as anti-cancer as well as wound healing agents.

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Photodynamic therapy for leishmaniasis: Recent advances and future trends

Cited by 22 publications

References 142 publications

Application of nano‐radiosensitizers in combination cancer therapy

Application of nano‐radiosensitizers in combination cancer therapy

Dexamethasone: Insights into Pharmacological Aspects, Therapeutic Mechanisms, and Delivery Systems

Next-Generation Hydrogels as Biomaterials for Biomedical Applications: Exploring the Role of Curcumin

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