Photodynamic therapy for Hidradenitis Suppurativa/acne inversa: Case report

Zhang, Yunjie; Yang, Yuguang; Zou, Xianbiao

doi:10.1016/j.pdpdt.2018.04.014

Cited by 10 publications

(13 citation statements)

References 6 publications

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“…A variety of ALA concentrations were included in this systematic review. 20% ALA was used in 14 studies [16-18, 28, 29, 32, 33, 38, 39, 42, 44-47], with other concentrations being 10% [19,36,37,43], 5% [35,41], 4% [40], and 2% [31,48,49]. This result also accorded with our animal experiment groping basically.…”

Section: Photosensitizer Concentrationsupporting

confidence: 82%

“…Study characteristics were summarized in Table 1. A total of 25 papers consisted of 9 case reports [16,18,19,[31][32][33][34][35][36], 5 pilot study [17,29,[37][38][39], 3 case series [40][41][42], 5 randomized controlled trials[28, [43][44][45][46] and 3 prospective observational studies [47][48][49]. Across the 25 included articles, a total of 335 patients were enrolled in all studies, ranging in age from 15 to 93 years.…”

Section: Methodsmentioning

confidence: 99%

“…were treated in studies reporting the sex of the subjects. The mean age of subjects was about In terms of population distribution of patients, skin cancers (105 patients) [31,33,36,37,43,44], leg and foot ulcers (62 patients) [28, 29,31,39,46] and anal fistula (59 patients) [48,49] were the most common diseases in the population, while carbuncle [32], chromosomiasis [18], leishmaniasis [34], hidradenitis suppurativa [35], and ulcerative necrobiosis lipoidica [19] were only a small subset with only one case in each study. CO2 laser injury (33 patients) [47], erosive oral lichen planus (22 patients) [40,41], Bowen's disease (BP) (18 patients) [45], erosive pustular dermatosis (14 patients) [16,38,42], furuncle and abscess (4 patients) [17], trauma (3 patients) [17] were moderate.…”

Section: Number Distribution Of Patientsmentioning

confidence: 99%

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5-Aminolevulinic Acid-Mediated Photodynamic Therapy on Wound Healing: A Systemic Review of Human Evidences

Huang,

Wang

2023

Journal of the American Podiatric Medical Association

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Backgrounds: Skin wounds are a kind of refractory disease frequently encountered in clinic, which brings enormous burden to patients. Great efforts to address the dilemma of wound healing have yielded some encouraging results, but they are still unsatisfactory. 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) has been developed as a promising noninvasive treatment for skin wounds. A systematic review was performed to determine the existing evidence base for the clinical use of ALA-PDT on refractory wounds. Methods: We conducted a PubMed search for English literature related to the clinical treatment of human skin ulcers by ALA-PDT published from 2012 to 2022, and performed a systematic review. Results: 25 studies were ultimately selected in the present review and summarized, including six studies of skin cancer, five studies of chronic leg ulcers, three studies of erosive pustular skin diseases, and two studies of erosive oral lichen planus symptoms. A total of 335 patients had approximately 355 ulcers, of which 315 ulcers received photodynamic therapy and 276 improved with ALA-PDT. 20% ALA solution, wavelength between 600 nm and 670 nm, energy density of 120 J/cm2, frequency of once per week and 3 sessions were the most selected therapeutic parameters. Generally, ALA-PDT for wounds was effective with main adverse events of mild to moderate pain, and follow-up was generally conducted within 1 year. Conclusions: This systematic review summarized the commonly used therapeutic parameters for ALA-PDT in the clinical treatment of skin wounds. After ALA-PDT alone or ALA-PDT combined with curettage, antibacterial and surgical treatment, all wounds healed well, and the adverse reactions were mainly mild to moderate pain, which could be relieved by cooling. ALA-PDT had proven to be a promising wound treatment modality through evidence of safety and efficacy.

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Section: Photosensitizer Concentrationsupporting

confidence: 82%

Section: Methodsmentioning

confidence: 99%

Section: Number Distribution Of Patientsmentioning

confidence: 99%

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5-Aminolevulinic Acid-Mediated Photodynamic Therapy on Wound Healing: A Systemic Review of Human Evidences

Huang,

Wang

2023

Journal of the American Podiatric Medical Association

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“…Two studies, with a total of four participants, used 5% ALA with an incubation period of 4 h under occlusion 24,25 . The light source was set to 96–126 J/cm 2 .…”

Section: Resultsmentioning

confidence: 99%

“…Two studies, with a total of four participants, used 5% ALA with an incubation period of 4 h under occlusion. 24 , 25 The light source was set to 96–126 J/cm 2 . While one patient had resolution of skin lesions, the three others had a poor response with no change in clinical symptoms.…”

Section: Resultsmentioning

confidence: 99%

Systematic review of photodynamic therapy for the treatment of hidradenitis suppurativa

Reshetylo

Narla

Bakker

et al. 2022

Photoderm Photoimm Photomed

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Objective: To perform a systematic review of available literature regarding the use of 5-aminolevulinic acid (ALA) and ALA derivative photodynamic therapy (PDT) in the treatment of hidradenitis suppurativa (HS) and provide recommendations on its use. Methods:A systematic review was performed of all published studies up to September 1, 2019 from nine databases, including PubMed, that evaluated PDT in the treatment of HS. For each study, quality of evidence and risk of bias was evaluated. Recommendations from the body of evidence were created based on Strength of Recommendation and Taxonomy (SORT) criteria.Results: Eighteen studies met inclusion criteria. The majority of studies had a high risk of bias. Blue light PDT with 20% ALA and red light PDT with 16% methyl aminolevulinate (MAL) demonstrated some benefit based on a small number of poor-quality studies with a high risk of bias (Grade C, level III evidence). The most promising results were for 1%-5% ALA with intralesional diode, with good to complete response in 78%-94% of anatomic sites treated (Grade B, level II evidence). Limitations:The majority of studies contained high levels of bias, with significant heterogeneity between studies. Conclusions are limited by small samples sizes, lack of randomized controlled trials, and differing protocols. Conclusion:Further studies are needed to determine the clinical efficacy of 20% ALA with blue light and MAL with red light. Intralesional diode PDT shows the most promise and warrants further investigation in larger, randomized controlled trials.

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Laser and Light-Based Treatment Modalities for the Management of Hidradenitis Suppurativa

et al. 2019

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Photodynamic therapy for Hidradenitis Suppurativa/acne inversa: Case report

Cited by 10 publications

References 6 publications

5-Aminolevulinic Acid-Mediated Photodynamic Therapy on Wound Healing: A Systemic Review of Human Evidences

5-Aminolevulinic Acid-Mediated Photodynamic Therapy on Wound Healing: A Systemic Review of Human Evidences

Systematic review of photodynamic therapy for the treatment of hidradenitis suppurativa

Laser and Light-Based Treatment Modalities for the Management of Hidradenitis Suppurativa

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