Photodynamic therapy for esophageal malignancy: A prospective twelve-year study

McCaughan, James S.; Ellison, E. Christopher; Guy, Jerry T.; Hicks, William; Jones, J. B.; Laufman, Leslie R.; May, Eugene; Nims, Thomas A.; Spiridonidis, C. Harris; Williams, Thomas E.

doi:10.1016/0003-4975(96)00563-2

Cited by 110 publications

(52 citation statements)

References 19 publications

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“…Local palliation with the aim to improve swallowing, short hospitalization, low complication rate, increase of KPS and quality of life, as well as economic aspects, especially in patients with a short life expactancy, are the goals of treatment of patients with advanced cancer of the cardia and the esophagus. PDT in the palliation of esophageal tumors as reported in the literature [14][15][16] is now a more and more accepted method and is used depending on its availability. However, there are some economic arguments against the use of PDT, especially in patients with a short life expectancy [17].…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric oxygen and photodynamic therapy in the treatment of advanced carcinoma of the cardia and the esophagus

et al. 2000

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Section: Discussionmentioning

confidence: 99%

Hyperbaric oxygen and photodynamic therapy in the treatment of advanced carcinoma of the cardia and the esophagus

et al. 2000

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“…Photodynamic therapy of cancer in the oesophagus and the tracheobronchial tree may occasionally result in severe complications, such as wall perforation, oesophago-tracheal fistula or stricture formation (Monnier et al, 1990;Hochain et al, 1993;Grosjean et al, 1996;McCaughan et al, 1996). Whereas massive tumour destruction may account for such a dramatic event after palliative PDT of a deep infiltrating cancer, transmural necrosis after PDT of a superficial carcinoma can only be explained by the non-selective damage of the healthy tissue underlying the tumour.…”

Section: Discussionmentioning

confidence: 99%

Clinical photodynamic therapy for superficial cancer in the oesophagus and the bronchi: 514 nm compared with 630 nm light irradiation after sensitization with Photofrin II

Grosjean

Wagnières²,

Fontolliet³

et al. 1998

Br J Cancer

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Summary Photodynamic therapy (PDT) for cancer in the oesophagus and bronchi with red (630 nm) light may occasionally lead to wall perforation and fistula. Therefore, we investigated the clinical use of a less penetrating wavelength (514 nm) for the curative treatment of nine superficial carcinomas in the oesophagus and bronchi after photosensitization with Photofrin II. Tumours without infiltration beyond the submucosa in the oesophagus and beyond the lamina propria in the bronchi were considered as superficial cancers. The outcome and complications were compared with those of 13 superficial cancers treated with PDT and 630 nm light. In addition, we evaluated histologically the extent of the long-term tissue damage and scarring following treatment of six oesophageal cancers with either green or red light. At first endoscopic control, 7-10 days after PDT, tissue necrosis simply matched the illuminated area, without evidence of selective tumour damage. Six of nine tumours treated with 514 nm light had a complete response compared with nine of 13 after 630 nm irradiation. No perforation or fistula occurred in either treatment group. However, severe chest pain and fever with or without pleural effusion, consistent with occult perforation, were observed in three patients after 630 nm illumination in the oesophagus. Histologically, fibrous scarring in the three distinct sites treated with green light was limited to the superficial layers of the oesophagus. After red light treatment, transmural fibrosis with marked thinning of the oesophageal wall was evident in two of the three specimens available for inspection. These results indicate that PDT with 514 nm light has the potential to cure superficial cancer in the oesophagus and bronchi with essentially the same probability of success as red light. In the oesophagus, green light prevents deep tissue damage, thus reducing the risk of perforation.

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“…In the literature, the complete remission rate of the Photophrinbased PDT (Photofrin-PDT) for early esophageal cancer is around 70% and 5-year survival around 60% according to the reports published in the last two decades, rates comparable to those obtained with surgery (23,26,27). Since the molecular mechanism of the resistance to PDT in esophageal cancer cells has hardly been investigated, an effective molecular marker available to predict response to PDT is lacking.…”

Section: Esophageal Cancermentioning

confidence: 99%

Translational research in thoracic surgery—the National Taiwan University Hospital experience

2016

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Thoracic surgeons should be more aware of the latest information about histopathological, genetic and epigenetic alterations that may influence treatment policy and patient outcome in the biomolecular era. Translational research studies often produce a promising diagnostic tool or new treatment that can be used clinically. The results of these translational studies may even change the practical guidelines and current staging system in thoracic malignancies. The following article summarizes the experiences of translational research in esophageal cancer and non-small cell lung cancer (NSCLC) at National Taiwan University Hospital in Taiwan.

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Photodynamic therapy for esophageal malignancy: A prospective twelve-year study

Cited by 110 publications

References 19 publications

Hyperbaric oxygen and photodynamic therapy in the treatment of advanced carcinoma of the cardia and the esophagus

Hyperbaric oxygen and photodynamic therapy in the treatment of advanced carcinoma of the cardia and the esophagus

Clinical photodynamic therapy for superficial cancer in the oesophagus and the bronchi: 514 nm compared with 630 nm light irradiation after sensitization with Photofrin II

Translational research in thoracic surgery—the National Taiwan University Hospital experience

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