Photodynamic therapy for early-stage cervical cancer treatment

Afanasiev, M. S.; Dushkin, Alexander; Grishacheva, T. G.; Afanasiev, S. S.; Karaulov, Alexander

doi:10.1016/j.pdpdt.2021.102620

Cited by 19 publications

(12 citation statements)

References 12 publications

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“…ROS can be produced by photosensitizers excessively in the field of light irradiation and then induce death in cancer cells through oxidative stress [ 47 ]. Due to these advantages, PDT has been extensively investigated for several decades due to its safety in cancer patients [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. However, deficiency in the cancer-specificity of traditional photosensitizers may arouse photosensitivity [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…In early stage cervical cancer, PDT leads to full human papillomavirus (HPV) elimination in more than 90% of cervical cancer patients [ 20 ]. Xu et al, also reported that PDT of cervical intraepithelial neoplasia using 5-ALA is an efficient option for diagnosis and therapy, i.e., 5-ALA treatment in a 10–30% concentration was safe for patients with negligible adverse events [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…The peculiarity of PDT for cancer patients is the fact that light irradiation at a specific wavelength only activates photosensitizers to generate ROS, i.e., absence of irradiation cannot activate them, and the surrounding cells/tissues receive negligible adverse effects [ 21 , 22 , 23 ]. These advantages promote the clinical application of various photosensitizers for cancer patients [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. PDT is a suitable treatment option for squamous cell carcinoma, such as skin cancers, cervical cancers and various epithelial cancers.…”

Section: Introductionmentioning

confidence: 99%

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CD44 Receptor-Mediated/Reactive Oxygen Species-Sensitive Delivery of Nanophotosensitizers against Cervical Cancer Cells

Yoon

Kim

Jeong

et al. 2022

IJMS

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Stimulus-sensitive, nanomedicine-based photosensitizer delivery has an opportunity to target tumor tissues since oxidative stress and the expression of molecular proteins, such as CD44 receptors, are elevated in the tumor microenvironment. The aim of this study is to investigate the CD44 receptor- and reactive oxygen species (ROS)-sensitive delivery of nanophotosensitizers of chlorin e6 (Ce6)-conjugated hyaluronic acid (HA) against HeLa human cervical cancer cells. For the synthesis of nanophotosensitizers, thioketal diamine was conjugated with the carboxyl group in HA and then the amine end group of HA-thioketal amine conjugates was conjugated again with Ce6 (Abbreviated as HAthCe6). The HAthCe6 nanophotosensitizers were of small diameter, with sizes less than 200. Their morphology was round-shaped in the observations using a transmission electron microscope (TEM). The HAthCe6 nanophotosensitizers responded to oxidative stress-induced changes in size distribution when H2O2 was added to the nanophotosensitizer aqueous solution, i.e., their monomodal distribution pattern at 0 mM H2O2 was changed to dual- and/or multi-modal distribution patterns at higher concentrations of H2O2. Furthermore, the oxidative stress induced by the H2O2 addition contributed to the disintegration of HAthCe6 nanophotosensitizers in morphology, and this phenomenon accelerated the release rate of Ce6 from nanophotosensitizers. In a cell culture study using HeLa cells, nanophotosensitizers increased Ce6 uptake ratio, ROS generation and PDT efficacy compared to free Ce6. Since HA specifically bonds with the CD44 receptor of cancer cells, the pretreatment of free HA against HeLa cells decreased the Ce6 uptake ratio, ROS generation and PDT efficacy of HAthCe6 nanophotosensitizers. These results indicated that intracellular delivery of HAthCe6 nanophotosensitizers can be controlled by the CD44 receptor-mediated pathway. Furthermore, these phenomena induced CD44 receptor-controllable ROS generation and PDT efficacy by HAthCe6 nanophotosensitizers. During in vivo tumor imaging using HeLa cells, nanophotosensitizer administration showed that the fluorescence intensity of tumor tissues was relatively higher than that of other organs. When free HA was pretreated, the fluorescence intensity of tumor tissue was relatively lower than those of other organs, indicating that HAthCe6 nanophotosensitizers have CD44 receptor sensitivity and that they can be delivered by receptor-specific manner. We suggest that HAthCe6 nanophotosensitizers are promising candidates for PDT in cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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CD44 Receptor-Mediated/Reactive Oxygen Species-Sensitive Delivery of Nanophotosensitizers against Cervical Cancer Cells

Yoon

Kim

Jeong

et al. 2022

IJMS

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“…Some physical methods constitute an alternative approach employed in current practice [16,17]. Several different approaches could be considered: cryotherapy [18]; photodynamic therapy (PDT) [19]; thermocoagulation [20]; CO 2 laser ablation [21]. However, chemotherapy has certain disadvantages and side effects which can vary according to the individual patient, the drugs used, the doses, and the combination treatments.…”

Section: Introductionmentioning

confidence: 99%

“…When the light is combined with a photosensitizer, it is called photodynamic therapy (PDT). PDT is a physicochemical method initially developed to treat cancer and tumors [19]. It was first approved in the 1980s, as a new approach intended for cancer patients who could not be treated by surgery or radiotherapy [43].…”

Section: Introductionmentioning

confidence: 99%

Phototherapy-Based Treatment for Sexually Transmitted Infections—Shining Light into Unexplored Territory

Hamblin

Rauger²,

Boyer

et al. 2022

Venereology

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New therapeutic strategies are urgently needed to overcome drawbacks in the treatment of some infections, particularly sexually transmitted infections (STI). STIs are easily spread by the transmission of various bacteria, viruses, and parasites with some of the infections being incurable or even lethal, leading to a serious impact on reproductive health worldwide. Phototherapy (PT) is a major therapeutic approach based on the controlled administration of light in the visible, near infrared, or UV spectrum, with or without the application of an external photosensitizer. Despite the fact that PT has not been explored to its full potential in the control of STIs, it has already demonstrated good clinical response rates and lower recurrence rates in genital infections. For instance, increasing evidence has demonstrated that 5-aminolevulinic acid photodynamic therapy (5-ALA-PDT) is effective in the treatment of condyloma acuminatum (CA), by eliminating the causative latent human papillomavirus (HPV) infection, and also in the antiviral treatment of recurrent genital herpes simplex virus (HSV) infections. The clinical application of PDT is a new treatment for oral fungal infection caused by Candida albicans in adult acquired immune deficiency syndrome (AIDS) patients, with human immunodeficiency virus (HIV), and could also be used for genital fungal infections. Another antimicrobial PT strategy, water-filtered infrared A combined with visible light irradiation, has been shown to be effective against genital Chlamydia trachomatis bacterial infection, and an optical nano-genosensor has been designed for the diagnosis of trichomoniasis, a parasitic Trichomonas vaginalis infection. This review aims to summarize the published evidence for the effectiveness of PT in the treatment of STIs, and for the suppression of STI-related pathogens of various types.

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Recent advancement of nanomedicine-based targeted delivery for cervical cancer treatment

Yadav,

Das,

Sharma

et al. 2023

Med Oncol

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Photodynamic therapy for early-stage cervical cancer treatment

Cited by 19 publications

References 12 publications

CD44 Receptor-Mediated/Reactive Oxygen Species-Sensitive Delivery of Nanophotosensitizers against Cervical Cancer Cells

CD44 Receptor-Mediated/Reactive Oxygen Species-Sensitive Delivery of Nanophotosensitizers against Cervical Cancer Cells

Phototherapy-Based Treatment for Sexually Transmitted Infections—Shining Light into Unexplored Territory

Recent advancement of nanomedicine-based targeted delivery for cervical cancer treatment

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