Photodynamic Therapy for Cancer and for Infections: What Is the Difference?

Sharma, Sunil; Mróz, Paweł; Dai, Tianhong; Huang, Ying‐Ying; Denis, Tyler G. St.; Hamblin, Michael R.

doi:10.1002/ijch.201100062

Cited by 88 publications

(68 citation statements)

References 133 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…PDT is thought to exert antitumor effects by three main mechanisms: (1) direct ROS-mediated cell cytotoxicity, (2) vascular destruction, and (3) stimulation of immune responses (Sharma et al 2012). ROS are highly reactive and exert toxicity mainly by damaging lipids, and to a lesser extent proteins and nucleic acids, thus leading to the disintegration of cell and organelle membranes.…”

Section: Mechanism Of Ps Action In Pdtmentioning

confidence: 99%

“…Some of the parameters that positively correlate with such accumulation are: high metabolic activity, tumour neoangiogenesis coupled with vascular leakiness and impaired lymphoid drainage, upregulation of LDL expression, decreased pH, and presence of macrophages (Sharma et al 2012). However, for some PSs, the dose achieved by passive accumulation is insufficient for therapeutic effect.…”

Section: Targeting Considerationsmentioning

confidence: 99%

See 1 more Smart Citation

Porphyrin-based cationic amphiphilic photosensitisers as potential anticancer, antimicrobial and immunosuppressive agents

2017

View full text Add to dashboard Cite

Photodynamic therapy (PDT) combines a photosensitiser, light and molecular oxygen to induce oxidative stress that can be used to kill pathogens, cancer cells and other highly proliferative cells. There is a growing number of clinically approved photosensitisers and applications of PDT, whose main advantages include the possibility of selective targeting, localised action and stimulation of the immune responses. Further improvements and broader use of PDT could be accomplished by designing new photosensitisers with increased selectivity and bioavailability. Porphyrin-based photosensitisers with amphiphilic properties, bearing one or more positive charges, are an effective tool in PDT against cancers, microbial infections and, most recently, autoimmune skin disorders. The aim of the review is to present some of the recent examples of the applications and research that employ this specific group of photosensitisers. Furthermore, we will highlight the link between their structural characteristics and PDT efficiency, which will be helpful as guidelines for rational design and evaluation of new PSs.

show abstract

Section: Mechanism Of Ps Action In Pdtmentioning

confidence: 99%

Section: Targeting Considerationsmentioning

confidence: 99%

Porphyrin-based cationic amphiphilic photosensitisers as potential anticancer, antimicrobial and immunosuppressive agents

2017

View full text Add to dashboard Cite

show abstract

“…If photodynamic therapy is now an established procedure for the treatment of certain non-oncological and oncological diseases [22,25,26], it is still not used for infection treatment [15,27]. In addition, the potential application of PDI to destroy (micro)organisms goes beyond the medical field, with particular focus on the environmental area [28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Potential applications of porphyrins in photodynamic inactivation beyond the medical scope

Alves

Faustino

Neves

et al. 2015

Journal of Photochemistry and Photobiology C: Photochemistry Re

195

128

View full text Add to dashboard Cite

a b s t r a c tAlthough the discovery of light-activated antimicrobial agents had been reported in the 1900s, only more recently research work has been developed toward the use of photodynamic process as an alternative to more conventional methods of inactivation of micro(organisms). The photoprocess causes cell death through irreversible oxidative damage by reactive oxygen species produced by the interaction between a photosensitizing compound and a light source.With great emphasis on the environmental area, photodynamic inactivation (PDI) has been tested in insect eradication and in water disinfection. Lately, other studies have been carried out concerning its possible use in aquaculture waters or to the control of food-borne pathogens. Other potential applications of PDI in household, industrial and hospital settings have been considered.In the last decade, scientific research in this area has gained importance not only due to great developments in the field of materials chemistry but also because of the serious problem of the increasing number of bacterial species resistant to common antibiotics. In fact, the design of antimicrobial surfaces or selfcleaning materials is a very appealing idea from the economic, social and public health standpoints. Thus, PDI of micro(organisms) represents a promising alternative.In this review, the efforts made in the last decade in the investigation of PDI of (micro)organisms with potential applications beyond the medical field will be discussed, focusing on porphyrins, free or immobilized on solid supports, as photosensitizing agents.

show abstract

“…Photodynamic therapy (PDT) is an effective treatment to kill both eukaryote and prokaryote cells [1,2]. It uses a drug called photosensitizer and a particular type of light.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and Antibiofilm Activities of the Photothermal Therapy Using Gold Nanorods against Seven Different Bacterial Strains

Castillo-Martínez

Martínez-Castañón

Martínez-Gutiérrez

et al. 2015

Journal of Nanomaterials

View full text Add to dashboard Cite

The objective of this work was to determine the bactericidal and antibiofilm activities of gold nanorods (AuNRs) using plasmonic photothermal therapy (PPTT) against oral microorganisms. AuNRs were synthesized by the seed and growth solution method and the gold nanoclusters were characterized with a size of 33.2 nm ± 2.23 length and 7.33 nm ± 1.60 width. The efficacy of PPTT related to its temperature was done reaching 67 ∘ C. Minimum inhibitory concentration (MIC) and minimum bactericide concentration (MBC) of AuNRs and AuNRs PPTT were determined against Enterococcus faecalis, Staphylococcus aureus, Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Streptococcus salivarius, and Escherichia coli growth. The antibiofilm activity of AuNRs was explored by fluorescence microscopy. After experimental analyses, AuNRs PPTT shows better results in MICs and MBCs, when it was compared with AuNRs alone. The laser employed to activate the AuNRs had no antibacterial effect against oral microbes. The MICs and MBCs values were higher for S. aureus and E. coli and lower against S. oralis. Surprisingly, the AuNRs alone presented a high antibiofilm activity, inhibiting the biofilm formation of S. mutans. Altogether, these results strongly suggest that AuNRs could be an interesting option to control oral biofilms.

show abstract

Photodynamic Therapy for Cancer and for Infections: What Is the Difference?

Cited by 88 publications

References 133 publications

Porphyrin-based cationic amphiphilic photosensitisers as potential anticancer, antimicrobial and immunosuppressive agents

Porphyrin-based cationic amphiphilic photosensitisers as potential anticancer, antimicrobial and immunosuppressive agents

Potential applications of porphyrins in photodynamic inactivation beyond the medical scope

Antibacterial and Antibiofilm Activities of the Photothermal Therapy Using Gold Nanorods against Seven Different Bacterial Strains

Contact Info

Product

Resources

About