Photodynamic therapy for actinic keratosis of the forehead and scalp: a randomized, controlled, phase<scp>II</scp>clinical study evaluating the noninferiority of a new protocol involving irradiation with a light‐emitting, fabric‐based device (the Flexitheralight protocol) compared with the conventional protocol involving irradiation with the Aktilite<scp>CL</scp>128 lamp

Vicentini, C.; Vignion‐Dewalle, Anne‐Sophie; Thecua, Elise; Lecomte, F.; Maire, Cyril; Deleporte, Pascal; Behal, Hélène; Kérob, Delphine; Duhamel, Alain; Mordon, Serge; Mortier, Laurent

doi:10.1111/bjd.17350

Cited by 33 publications

(47 citation statements)

References 28 publications

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“…Studies are ongoing to refine ‘Textile PDT’ where red 635 nm light is delivered through fabric from laser diodes, to slowly expose the skin to the same light dose as for conventional PDT . As light intensity is reduced and incubation short, treatment is almost pain‐free.…”

Section: Treatment Protocolsmentioning

confidence: 99%

“…36,37 A novel light-emitting, fabric-based laser diode device has recently been shown to be as effective as conventional PDT in clearing AK but with minimal pain, with MAL applied under a transparent occlusive dressing for 30 min then fabric device is applied and switched on after 30 min, remaining on for 150 min. 38…”

Section: Daylight Ambulatory Led and Fabric-based Laser Diode Illumi-mentioning

confidence: 99%

“…36,37 Studies are ongoing to refine 'Textile PDT' where red 635 nm light is delivered through fabric from laser diodes, to slowly expose the skin to the same light dose as for conventional PDT. 38 As light intensity is reduced and incubation short, treatment is almost pain-free. The fabric allows for uniform light distribution even on curved surfaces, with potential to treat much larger areas.…”

Section: Daylight Pdt (Dl Mal-pdt DL Ala-pdt)mentioning

confidence: 99%

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European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 1: treatment delivery and established indications – actinic keratoses, Bowen's disease and basal cell carcinomas

Morton¹,

Szeimies

Basset-Séguin

et al. 2019

Acad Dermatol Venereol

132

146

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Topical photodynamic therapy (PDT) is a widely approved therapy for actinic keratoses, Bowen's disease (squamous cell carcinoma in situ), superficial and certain thin basal cell carcinomas. Recurrence rates when standard treatment protocols are used are typically equivalent to existing therapies, although inferior to surgery for nodular basal cell carcinoma. PDT can be used both as lesional and field therapies and has the potential to delay/reduce the development of new lesions. A protocol using daylight to treat actinic keratoses is widely practised, with conventional PDT using a red light after typically a 3‐h period of occlusion employed for other superficial skin cancer indications as well as for actinic keratoses when daylight therapy is not feasible. PDT is a well‐tolerated therapy although discomfort associated with conventional protocol may require pain‐reduction measures. PDT using daylight is associated with no or minimal pain and preferred by patient. There is an emerging literature on enhancing conventional PDT protocols or combined PDT with another treatment to increase response rates. This guideline, published over two parts, considers all current approved and emerging indications for the use of topical PDT in dermatology, prepared by the PDT subgroup of the European Dermatology Forum guidelines committee. It presents consensual expert recommendations reflecting current published evidence.

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Section: Treatment Protocolsmentioning

confidence: 99%

Section: Daylight Ambulatory Led and Fabric-based Laser Diode Illumi-mentioning

confidence: 99%

Section: Daylight Pdt (Dl Mal-pdt DL Ala-pdt)mentioning

confidence: 99%

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European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 1: treatment delivery and established indications – actinic keratoses, Bowen's disease and basal cell carcinomas

Morton¹,

Szeimies

Basset-Séguin

et al. 2019

Acad Dermatol Venereol

132

146

View full text Add to dashboard Cite

show abstract

“…Vicentini et al performed a study evaluating PDT using a light‐emitting fabric device delivering fractionated red light at a low irradiance of 12 mW/cm 2 (Li‐PDT) (Vicentini et al, ). After 30 min of MAL incubation, the Li‐PDT device was switched on and illumination was performed for 2 hr 30 min giving a light dose of 37 J/cm 2 (Figure ).…”

Section: Data Reported For the Clinical Studies Included In The Reviementioning

confidence: 99%

“…Pain scores (0–10) versus irradiance (mW/cm 2 ). Data were obtained from Gholam et al (), Ibbotson and Ferguson (), and Vicentini et al ()…”

Section: Data Reported For the Clinical Studies Included In The Reviementioning

confidence: 99%

Low‐irradiance red light compared to conventional red light in photodynamic therapy of actinic keratosis: A way to reduce pain during treatment

Mordon

Vignion‐Dewalle

2019

Dermatologic Therapy

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Principles of Photodynamic Therapy

Ibbotson,

McKenna

2024

Rook's Textbook of Dermatology

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Topical photodynamic therapy (PDT) is widely used as an effective and well‐tolerated treatment for field change actinic keratosis, Bowen disease and superficial basal cell carcinoma. There is a strong evidence base to support its use and guidelines, which summarise the evidence and clinical utility of this therapy. There are also standards available for guidance with respect to establishing PDT services in dermatology and emphasis is placed on the availability of PDT for practitioners affiliated with a skin cancer multi‐disciplinary team. Developments in photosensitisers and light delivery, such as through the increasing application of daylight PDT, have greatly improved the tolerance, acceptability and uptake of PDT, such that this should be widely available through dermatology services. Further refinements in photosensitiser and light delivery will be expected to continue to improve PDT outcomes and the uptake of this invaluable therapeutic approach.

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Abstract: This summary relates to https://doi.

Cited by 33 publications

References 28 publications

European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 1: treatment delivery and established indications – actinic keratoses, Bowen's disease and basal cell carcinomas

European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 1: treatment delivery and established indications – actinic keratoses, Bowen's disease and basal cell carcinomas

Low‐irradiance red light compared to conventional red light in photodynamic therapy of actinic keratosis: A way to reduce pain during treatment

Principles of Photodynamic Therapy

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