Photodynamic Therapy for Acne Vulgaris With Topical 5-Aminolevulinic Acid

Itoh, Yoshiyasu; Ninomiya, Yoshiharu; Tajima, S.; Ishibashi, Akira

doi:10.1001/archderm.136.9.1093

Cited by 134 publications

(102 citation statements)

References 8 publications

(10 reference statements)

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“…Improvements usually started 3 weeks after PDT first session. Almost at the same time, other authors showed ALA-PDT efficacy in acne treatment, reporting also that improvements lasted for at least 6 months and that 1 PDT session may be not enough [20,21] . Nevertheless, almost 16 years have passed since the first studies on ALA-PDT in acne therapy; there is still no consensus on how to perform PDT for acne treatment, and its use still remains an off-label option for acne patients [22] .…”

Section: Acnementioning

confidence: 84%

“…Nevertheless, almost 16 years have passed since the first studies on ALA-PDT in acne therapy; there is still no consensus on how to perform PDT for acne treatment, and its use still remains an off-label option for acne patients [22] . Despite numerous studies on PDT in acne (mainly mild to severe acne on the face but also acne lesions on the back and acne conglobata) [1,18,20,21,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] ( Table 1 ), they are generally difficult to compare because of the lack of controls, qualitative non-blinded methods, variable light dosimetry, and an extremely wide variation of the incubation time between drug application and light exposure. All these differences should not be neglected.…”

Section: Acnementioning

confidence: 99%

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Photodynamic Therapy and Skin Appendage Disorders: A Review

Megna

Fabbrocini

Marasca

et al. 2016

Skin Appendage Disord

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Photodynamic therapy (PDT) is a noninvasive treatment that utilizes light treatment along with application of a photosensitizing agent. In dermatology, PDT is commonly used and approved for the treatment of oncological conditions such as actinic keratosis, Bowen disease and superficial basal cell carcinoma. In the last 2 decades however, PDT has also been used for the treatment of several nonneoplastic dermatological diseases. The present review summarizes published data on PDT application in skin appendage disorders. Our literature review shows that: (a) PDT may be a suitable treatment for acne, folliculitis decalvans, hidradenitis suppurativa, nail diseases, and sebaceous hyperplasia; (b) there is a lack of agreement on PDT features (type, concentrations and incubation period of used substances, number and frequency of PDT sessions, optimal parameters of light sources, and patient characteristics [e.g., failure to previous treatments, disease severity, body surface area involved, etc.] which should guide PDT use in these diseases); (c) further research is needed to establish international guidelines helping dermatologists to choose PDT for the right patient at the right time.

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Section: Acnementioning

confidence: 84%

Section: Acnementioning

confidence: 99%

Photodynamic Therapy and Skin Appendage Disorders: A Review

Megna

Fabbrocini

Marasca

et al. 2016

Skin Appendage Disord

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“…ALA-PDT can be beneficial for acne particularly because it destroys pilosebaceous units as well as P. acnes [52][53][54]. Although its efficacy has been reported with variable mean percentage reduction rates from 32% to 72% according to different authors [55][56][57][58][59][60][61][62], ALA-PDT would not appear to offer significant advantage in the treatment of acne, particularly when the adverse effects of considerable long-lasting post inflammatory hyperpigmentation (PIH) following severe acute local reactions are taken into account, which is especially the case in dark-skinned individuals of Asian origin [19,55,[58][59][60][61][62]. In addition, the time lapse for ALA incubation and the necessity of vigorous sun protection to avoid potential phototoxic reactions for several days after ALA-PDT may decrease the patients' satisfaction level regarding this therapy [19].…”

Section: Discussionmentioning

confidence: 99%

Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV

2006

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Background and Objectives: Blue light is effective for acne treatment, inducing photodynamic destruction of Propionibacterium acnes (P. acnes). This study was designed to investigate the efficacy of combined blue and red light-emitting diode (LED) phototherapy for acne vulgaris. Materials and Methods: Twenty-four patients with mild to moderately severe facial acne were treated with quasimonochromatic LED devices, alternating blue (415 nm) and red (633 nm) light. The treatment was performed twice a week for 4 weeks. Objective assays of the skin condition were carried out before and after treatment at each treatment session. Clinical assessments were conducted before treatment, after the 2nd, 4th, and 6th treatment sessions and at 2, 4, and 8 weeks after the final treatment by grading and lesion counting. Results: The final mean percentage improvements in noninflammatory and inflammatory lesions were 34.28% and 77.93%, respectively. Instrumental measurements indicated that the melanin levels significantly decreased after treatment. Brightened skin tone and improved skin texture were spontaneously reported by 14 patients. Conclusion: Blue and red light combination LED phototherapy is an effective, safe and non-painful treatment for mild to moderately severe acne vulgaris, particularly for papulopustular acne lesions.

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“…These authors concluded that oral use of ALA associated with visible polychromatic light is effective for the treatment of body acne. 28 Some articles mention the use of blue light alone and others compare the greater benefit of ALA in association with this light. The incubation time of ALA varies from study to study, ranging from fifteen minutes to three hours.…”

Section: Nonmalignant Skin Diseases Acnementioning

confidence: 99%

Terapia fotodinâmica: revisão da literatura e documentação iconográfica

Issa

Manela-Azulay

2010

An. Bras. Dermatol.

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Photodynamic therapy (PDT) consists of a chemical reaction activated by light energy that is used to selectively destroy tissue. The reaction requires a photosensitizer in the target tissue, a light source and oxygen. The most extensively studied photosensitizing agents for PDT are 5-aminolevulinic acid for the treatment of actinic keratosis and methyl-aminolevulinate, which has been approved for the treatment of actinic keratosis, basal cell carcinoma and Bowen's disease. The light sources used in photodynamic therapy should emit light at wavelengths within the absorption spectrum of the photosensitizer used in PDT treatment. Light emitting diode (LED) lamps are indicated for the photodynamic treatment of nonmelanoma skin cancer. PDT should be considered as a therapeutic option, particularly in the case of patients with superficial, multiple or disseminated lesions and for immunosuppressed patients. More recently, PDT has been indicated for a wide range of dermatological conditions such as photo-damaged skin, acne, hidradenitis, scleroderma, psoriasis, warts and leishmaniosis, among others. This article provides an extensive review of photodynamic therapy, its mechanisms, indications and results. Keywords: 5-aminolevulinate synthetase; Photochemotherapy; Review Resumo: A terapia fotodinâmica é uma reação química ativada por luz usada para destruição seletiva de um tecido e requer um agente fotossensibilizante no tecido-alvo, uma fonte de luz e oxigênio. Estão disponíveis, no momento, o ácido 5-aminolevulínico para tratamento de ceratoses actínicas e o metilaminolevulinato, aprovado para tratamento de ceratoses actínicas, carcinoma basocelular e doença de Bowen. As fontes de luz utilizadas para a terapia fotodinâmica devem emitir comprimentos de onda no espectro de absorção do fotossensibilizante escolhido. As lâmpadas LED (light emitting diode) são as indicadas para terapia fotodinâmica tópica no tratamento do câncer de pele não melanoma. A terapia fotodinâmica deve ser considerada, em particular, para pacientes que apresentam lesões superficiais, múltiplas, disseminadas e para pacientes imunossuprimidos. Mais recentemente, a terapia fotodinâmica tem sido indicada no tratamento do fotoenvelhecimento, acne, hidrosadenite, esclerodermia, psoríase, verrugas, leishmaniose, entre outras. Por este trabalho será possível ter acesso a uma extensa revisão da literatura sobre terapia fotodinâmica, seus mecanismos, indicações e resultados, seguida de comentários e críticas pertinentes ao assunto. Palavras-chave: 5-aminolevulinato sintetase; Fotoquimioterapia; Revisão

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Photodynamic Therapy for Acne Vulgaris With Topical 5-Aminolevulinic Acid

Cited by 134 publications

References 8 publications

Photodynamic Therapy and Skin Appendage Disorders: A Review

Photodynamic Therapy and Skin Appendage Disorders: A Review

Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV

Terapia fotodinâmica: revisão da literatura e documentação iconográfica

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