2019
DOI: 10.1002/adhm.201900996
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Photodynamic Therapy Combined with Antihypoxic Signaling and CpG Adjuvant as an In Situ Tumor Vaccine Based on Metal–Organic Framework Nanoparticles to Boost Cancer Immunotherapy

Abstract: Photodynamic therapy (PDT) usually aggravates tumor hypoxia, which promotes the survival and metastasis of residue cancer cells; furthermore, although PDT‐induced immunogenic death of cancer cells can induce host antitumor responses, such responses are generally weak and not enough to eliminate the residue cancer cells. Here, metal–organic framework (MOF)‐based nanoparticles to combine PDT, antihypoxic signaling, and CpG adjuvant as an in situ tumor vaccine to boost host anticancer responses after PDT are desi… Show more

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Cited by 129 publications
(91 citation statements)
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“…Importantly, this inexpensive HA nanoparticle-based delivery system could enhance the bioavailability of CpG ODNs and reduce the risk of side effects caused by positively-charged cationic lipids, which made these adjuvant-loaded nanomedicines safer and more affordable for cancer immunotherapy. In addition to delivering CpG ODN with Poly I: C, in another recent study [ 258 ], HA-based nanoparticles were employed to load CpG along with another therapeutic hypoxia inducible factor: signaling inhibitor Acriflavine (ACF) [ [259] , [260] , [261] ]. In this study, HA coated metal–organic framework-based nanoparticles were synthesized through H2TCPP and zirconium ions as a delivery platform (PCN-ACF-CpG@HA).…”
Section: Hyaluronic Acid-based Nanomedicinesmentioning
confidence: 99%
“…Importantly, this inexpensive HA nanoparticle-based delivery system could enhance the bioavailability of CpG ODNs and reduce the risk of side effects caused by positively-charged cationic lipids, which made these adjuvant-loaded nanomedicines safer and more affordable for cancer immunotherapy. In addition to delivering CpG ODN with Poly I: C, in another recent study [ 258 ], HA-based nanoparticles were employed to load CpG along with another therapeutic hypoxia inducible factor: signaling inhibitor Acriflavine (ACF) [ [259] , [260] , [261] ]. In this study, HA coated metal–organic framework-based nanoparticles were synthesized through H2TCPP and zirconium ions as a delivery platform (PCN-ACF-CpG@HA).…”
Section: Hyaluronic Acid-based Nanomedicinesmentioning
confidence: 99%
“…The modified oxygen-boosted PDT displayed infiltration of cytotoxic T lymphocytes (CTLs) in TME and a better induction of ICD in 4T1 murine breast cancer cells by elevating cell surface exposure of CRT, increasing release of HMGB1 and ATP, and afterwards promoting the maturation of DCs ( 57 ). Combing metal-organic framework-based nanoparticles to PDT was also of benefit for alleviating PDT-induced hypoxia via inhibiting hypoxia inducible factor-1α ( 59 ). The combination of nanomaterials or anti-hypoxic treatment with PDT may help it to achieve a better clinical realization.…”
Section: Approaches To Produce Immunogenic Cell Death-based Cancer Vaccinesmentioning
confidence: 99%
“…To counter this phenomenon, Cai et al . [ 78 ] developed a similar photosensitive MOF (denoted PCN-ACF-CpG@HA, Fig. 17 b) to that of Ni et al .…”
Section: Immunotherapymentioning
confidence: 99%