Photodynamic Therapy as an Adjunct to Surgery or Other Treatments for Squamous Cell Lung Cancers

Jheon, Sanghoon; Kim, Jongki

doi:10.5978/islsm.20.107

Cited by 4 publications

(2 citation statements)

References 9 publications

(5 reference statements)

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“…It also has good compatibility with common treatment methods [3]. It can be combined with interventional tumor reduction under bronchoscope or surgery to achieve better results [10]; In addition, studies have confirmed that PDT combined with radiotherapy can produce superimposed therapeutic effect, which is safe and effective [11,12]; Moreover, PDT combined with chemotherapy is not only effective but also can reduce the number of chemotherapy cycle, thus reducing the side effects on the body. [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Analysis of the short-term effect of photodynamic therapy on primary bronchial lung cancer

et al. 2020

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To analyze the short-term clinical effect of photodynamic therapy on bronchial lung cancer and provide relevant practical experience for its better application in clinical practice. Twenty patients with bronchial lung cancer diagnosed by pathology were treated with photodynamic therapy or interventional tumor reduction combined with photodynamic therapy. Follow-up at 3 months after treatment, the chest CT and bronchoscopy were reexamined. The lesions were observed under a microscope, and the pathological specimens of living tissues were stained with HE and TUNEL to evaluate the short-term clinical effect. The volume of the tumor in the trachea or bronchus was smaller than before and the obstruction improved after the PDT from the chest CT. We could conclude that after PDT, the tumor volume was reduced and the pathological tissue appeared necrotic, the surface was pale, and the blood vessels were fewer while compared with before, and less likely to bleed when touched from the results of the bronchoscopy. HE staining showed that before treatment, there were a large number of tumor cells, closely arranged and disordered, or agglomerated and distributed unevenly. The cell morphology was not clear and the sizes were various with large and deeply stained nucleus, and the intercellular substance was less. After treatment, the number of tumor cells decreased significantly compared with before and the arrangement was relatively loose and orderly. The cells were roughly the same size; the intercellular substance increased obviously and showed uniform staining. The nuclei morphology was incomplete and fragmented, and tumor cells were evenly distributed among the intercellular substance. TUNEL staining showed that the number of cells was large and the nucleus morphology was regular before treatment; the nuclear membrane was clear and only a small number of apoptotic cells could be seen. However, the number of cells decreased and arranged loosely after treatment, with evenly stained cytoplasm. The nuclear morphology was irregular and the nuclear membrane cannot be seen clearly. Apoptotic cells with typical characteristics such as karyopyknosis, karyorrhexis, and karyolysis were common. Photodynamic therapy for bronchial lung cancer can achieve a satisfactory short-term clinical treatment effect and improve the life quality of patients, but the long-term clinical effect remains to be further studied.

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Section: Discussionmentioning

confidence: 99%

Analysis of the short-term effect of photodynamic therapy on primary bronchial lung cancer

et al. 2020

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“…Palliative treatment [11][12][13][14][15][16][17][18] Palliative treatment should be offered to patients with: i Primary or metastatic tracheobronchial malignancies ii Multiple primary central lung cancer iii Local recurrence of stump after lung cancer surgery iv Local recurrence of central lung cancer after radiotherapy.…”

Section: Treatment Of Early Airway Malignant Tumorsmentioning

confidence: 99%

Clinical application of photodynamic therapy for malignant airway tumors in China

Jin¹,

Wang

et al. 2019

Thoracic Cancer

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With the development of interventional pulmonology, photodynamic therapy (PDT) is gradually being used in the treatment of respiratory malignant tumors because of its low level of trauma, high specificity, and compatibility with traditional or common therapies. However, at present, the data of clinical evidencebased medicine for PDT applied in central airway tumors is very limited, and derives mainly from case reports or series of case studies which lack consensus on clinical diagnosis and treatment. In order to further disseminate China's experience, the Tumor Photodynamic Therapy Committee of China Anti-Cancer Association and the World Endoscopy Association-Respiratory Endoscopy Association invited experts from relevant fields to form an expert committee. After several rounds of discussion and revision by this committee, and following a vote, the consensus was formulated for reference by physicians in respiratory, oncology and other related disciplines to refer to the practice of tumor photodynamic therapy.

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Stabilized tetraether lipids based particles guided prophyrins photodynamic therapy

et al. 2018

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Photodynamic therapy (PDT) that involves ergonomically delivered light in the presence of archetypical photosensitizer such as Protoporphyrin IX (PpIX) is a time-honored missile strategy in cancer therapeutics. Yet, the premature release of PpIX is one of the most abundant dilemma encounters the therapeutic outcomes of PDT due to associated toxicity and redistribution to serum proteins. In this study, ultrastable tetraether lipids (TELs) based liposomes were developed. PpIX molecules were identified to reside physically in the monolayer; thereby the inherent π-π stacking that leads to aggregation of PpIX in aqueous milieu was dramatically improved. TEL29.9 mol% and TEL62mol% based liposomes revealed PpIX sustained release diffusion pattern from spherical particles as confirmed by converged fitting to Baker & Lonsdale model. Stability in presence of human serum albumins, a key element for PDT accomplishment was emphasized. The epitome candidates were selected for vascular photodynamic (vPDT) in in-Ovo chick chorioallantoic membrane. Profoundly, TEL62mol% based liposomes proved to be the most effective liposomes that demonstrated localized effect within the irradiated area without eliciting quiescent vasculatures damages. Cellular photodynamic therapy (cPDT) revealed that various radiant exposure doses of 134, 202, 403 or 672 mJ.cm−2 could deliberately modulate the photo-responses of PpIX in TEL-liposomes.

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Photodynamic Therapy as an Adjunct to Surgery or Other Treatments for Squamous Cell Lung Cancers

Cited by 4 publications

References 9 publications

Analysis of the short-term effect of photodynamic therapy on primary bronchial lung cancer

Analysis of the short-term effect of photodynamic therapy on primary bronchial lung cancer

Clinical application of photodynamic therapy for malignant airway tumors in China

Stabilized tetraether lipids based particles guided prophyrins photodynamic therapy

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