Photodynamic therapy and photothermal therapy for the treatment of peritoneal metastasis: a systematic review

Abstract

BackgroundThe aim of this review was to analyze preclinical studies and clinical trials evaluating photodynamic therapy (PDT), and photothermal therapy (PTT) in peritoneal metastasis (PM) treatment.ContentSystematic review according PRISMA guidelines. Electronic searches using PubMed and Clinical Trials.SummaryA total of 19 preclinical studies analyzing PDT in PM treatment were included. Each new generations of photosensitizers (PS) permitted to improve tumoral targeting. Phase III preclinical studies showed an important tumoral biodistribution (ratio 9.6 vs normal tissue) and significant survival advantage (35.5 vs 52.5 days for cytoreductive surgery vs cytoreductive surgery+PDT, p<0.005). Height clinical trials showed important side effects (capillary leak syndrome and bowel perforation), mainly explained by low tumor-selectivity of the PS used (first generation mainly).Peritoneal mesothelioma apparition with carbon nanotubes first limited the development of PTT. But gold nanoparticles, with a good tolerance, permitted a limitation of tumoral growth (reduction of bioluminescence to 37 % 20 days after PTT), and survival benefit (35, 32, and 26 days for PTT with cisplatine, PTT alone and laser alone, respectively).OutlookRecent improvement in tumor-selectivity and light delivery systems is promising but further development would be necessary before PDT and PTT routinely applied for peritoneal carcinomatosis.

Risk Evaluation of EMT and Inflammation in Metastatic Pancreatic Cancer Cells Following Plasma Treatment

“…However, new concepts of cancer therapies are under investigation. This includes immunotherapies [2], target-specific drugs [3,4], or technological innovations such as photodynamic [5,6] and cold physical plasma therapy [7]. Cold physical plasmas are partially ionized gases generating a plethora of reactive species (ROS) besides other components such as electric fields, temperature, light of different wavelengths, and charged particles [8,9].…”

Hyperthermic intraperitoneal chemotherapy with cisplatin and mitomycin C for colorectal cancer peritoneal metastases: A systematic review of the literature

“…This protocol represents a potential alternative for now. We expect, in the next 10 years, new drug delivery systems, immunotherapy combined with chemotherapeutic, and development of nanovectorization, a new therapeutic area, to improve actual survival and decrease morbidity [51].…”

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“…More clarity about which strategy is being referred to is necessary since, through ICG, one thing does not exclude the other, and the related side effects should be considered as well. Both PTT and PDT are promising for the treatment of several malignancies; however, it is important to understand which aspect to target to design the appropriate NPs (Pinto and Pocard, 2018 ).…”