Photodynamic Therapy and Fluorescent Diagnostics in the Russian Federation

Photodynamic Therapy for Cancer: What's Past is Prologue

“…Photodithazine (Fotoditazin) is the N‐dimethylglucamine salt of chlorin(e6) invented by Ponomarev Helium Vasilievich, prepared by Veta‐Grand LLC, Moscow, Russia, and has received regulatory approval in Russia . It has been mainly studied as an antimicrobial PS, but has been used in clinical trials of basal cell carcinoma of the skin and in case studies in advanced lung cancer, bladder cancer and brain tumors .…”

“…It received a series of regulatory approvals in Russia between 2001 and 2008. It is used at an IV dose of 0.3–0.8 mg kg −1 , with multiple 675 nm laser irradiations delivered between 24 and 72 h postinjection each at 80–100 J cm −2 with a total up to 600 J cm −2 . It has been tested in Russian clinical trials for basal cell carcinoma, advanced lung cancer, recurrent head and neck cancer, primary or recurrent gastric cancer, cancer of the esophagus, pleural mesothelioma and breast cancer metastases .…”