Photodynamic therapy and associated targeting methods for treatment of brain cancer

Bartusik-Aebisher, Dorota; Serafin, Iga; Dynarowicz, Klaudia; Aebisher, David

doi:10.3389/fphar.2023.1250699

Cited by 8 publications

(2 citation statements)

References 156 publications

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“…The search for innovative forms of therapy, including photodynamic therapy (PDT), is ongoing. Photodynamic therapy exploits photodynamic action initiated by the excitation of photosensitizers (PSs) with light and the subsequent interaction of the excited PSs with oxygen to produce reactive oxygen species (ROS) including singlet oxygen ( 1 O 2 ) [11,12]. Figure 1 presents the mechanism of 1 O 2 generation upon excitation of a PS.…”

Section: Photodynamic Therapy-one Of the Treatment Methodsmentioning

confidence: 99%

Photodynamic Therapy and Immunological View in Gastrointestinal Tumors

Aebisher,

Woźnicki,

Dynarowicz

et al. 2023

Cancers

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Gastrointestinal cancers are a specific group of oncological diseases in which the location and nature of growth are of key importance for clinical symptoms and prognosis. At the same time, as research shows, they pose a serious threat to a patient’s life, especially at an advanced stage of development. The type of therapy used depends on the anatomical location of the cancer, its type, and the degree of progression. One of the modern forms of therapy used to treat gastrointestinal cancers is PDT, which has been approved for the treatment of esophageal cancer in the United States. Despite the increasingly rapid clinical use of this treatment method, the exact immunological mechanisms it induces in cancer cells has not yet been fully elucidated. This article presents a review of the current understanding of the mode of action of photodynamic therapy on cells of various gastrointestinal cancers with an emphasis on colorectal cancer. The types of cell death induced by PDT include apoptosis, necrosis, and pyroptosis. Anticancer effects are also a result of the destruction of tumor vasculature and activation of the immune system. Many reports exist that concern the mechanism of apoptosis induction, of which the mitochondrial pathway is most often emphasized. Photodynamic therapy may also have a beneficial effect on such aspects of cancer as the ability to develop metastases or contribute to reducing resistance to known pharmacological agents.

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Section: Photodynamic Therapy-one Of the Treatment Methodsmentioning

confidence: 99%

Photodynamic Therapy and Immunological View in Gastrointestinal Tumors

Aebisher,

Woźnicki,

Dynarowicz

et al. 2023

Cancers

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“…PDT has transcended its initial applications and found utility across multiple medical disciplines. From dermatology to ophthalmology and beyond, the versatility of PDT has expanded, demonstrating its adaptability in addressing a diverse array of diseases and conditions [196]. Ongoing research has led to the development of more efficient and selective photosensitizing agents.…”

Section: Clinical Use Advances and Limitations In The Use Of Photodyn...mentioning

confidence: 99%

Photodynamic Therapy for Eye, Ear, Laryngeal Area, and Nasal and Oral Cavity Diseases: A Review

Domka,

Bartusik-Aebisher,

Mytych

et al. 2024

Cancers

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Photodynamic therapy (PDT) has emerged as a promising modality for the treatment of various diseases. This non-invasive approach utilizes photosensitizing agents and light to selectively target and destroy abnormal cells, providing a valuable alternative to traditional treatments. Research studies have explored the application of PDT in different areas of the head. Research is focusing on a growing number of new developments and treatments for cancer. One of these methods is PDT. Photodynamic therapy is now a revolutionary, progressive method of cancer therapy. A very important feature of PDT is that cells cannot become immune to singlet oxygen. With this therapy, patients can avoid lengthy and costly surgeries. PDT therapy is referred to as a safe and highly selective therapy. These studies collectively highlight the potential of PDT as a valuable therapeutic option in treating the head area. As research in this field progresses, PDT may become increasingly integrated into the clinical management of these conditions, offering a balance between effectiveness and minimal invasiveness.

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Long term follow-up of patients with newly diagnosed glioblastoma treated by intraoperative photodynamic therapy: an update from the INDYGO trial (NCT03048240)

Peciu-Florianu,

Vannod-Michel,

Vauleon

et al. 2024

J Neurooncol

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Purpose Glioblastoma remains incurable despite optimal multimodal management. The interim analysis of open label, single arm INDYGO pilot trial showed actuarial 12-months progression-free survival (PFS) of 60% (median 17.1 months), actuarial 12-months overall survival (OS) of 80% (median 23.1 months). We report updated, exploratory analyses of OS, PFS, and health-related quality of life (HRQOL) for patients receiving intraoperative photodynamic therapy (PDT) with 5-aminolevulinic acid hydrochloride (5-ALA HCl). Methods Ten patients were included (May 2017 – April 2021) for standardized therapeutic approach including 5-ALA HCl fluorescence-guided surgery (FGS), followed by intraoperative PDT with a single 200 J/cm2 dose of light. Postoperatively, patients received adjuvant therapy (Stupp protocol) then followed every 3 months (clinical and cerebral MRI) and until disease progression and/or death. Procedure safety and toxicity occurring during the first four weeks after PDT were assessed. Data concerning relapse, HRQOL and survival were prospectively collected and analyzed. Results At the cut-off date (i.e., November 1st 2023), median follow-up was 23 months (9,7–71,4). No unacceptable or unexpected toxicities and no treatment-related deaths occurred during the study. Kaplan–Meier estimated 23.4 months median OS, actuarial 12-month PFS rate 60%, actuarial 12-month, 24-month, and 5-year OS rates 80%, 50% and 40%, respectively. Four patients were still alive (1 patient free of recurrence). Conclusion At 5 years-follow-up, intraoperative PDT with surgical maximal excision as initial therapy and standard adjuvant treatment suggests an increase of time to recurrence and overall survival in a high proportion of patients. Quality of life was maintained without any severe side effects. Trial registration NCT number NCT03048240. EudraCT number: 2016–002706-39.

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Photodynamic therapy and associated targeting methods for treatment of brain cancer

Cited by 8 publications

References 156 publications

Photodynamic Therapy and Immunological View in Gastrointestinal Tumors

Photodynamic Therapy and Immunological View in Gastrointestinal Tumors

Photodynamic Therapy for Eye, Ear, Laryngeal Area, and Nasal and Oral Cavity Diseases: A Review

Long term follow-up of patients with newly diagnosed glioblastoma treated by intraoperative photodynamic therapy: an update from the INDYGO trial (NCT03048240)

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