Photodynamic therapy: A real‐world analysis of outcomes of photodynamic therapy in an Australian tertiary dermatology clinic

Lim, Chloe M; Grillo, Marianne; Harrison, Penelope; Nguyen, Anh–Minh; Gordon, Lynne Thomas

doi:10.1111/ajd.13043

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…Lim and colleagues’ 2019 study (A), a retrospective review looking at PDT for AK, SCC in situ , superficial BCC, nodular BCC and lichen planus in a mix of immunocompetent and transplant patients, did not mirror the reduced response with overall clearance rates in the immunosuppressed/SOTR cohort steady from 74% to 80% at 12 weeks and 12 months, respectively, with no statistically significant difference between SOTR/immunosuppressed and immunocompetent (76% clear at 12 weeks and 73% clear at 12 months).…”

Section: Review Of Photodynamic Therapy Outcomes In Solid Organ Transmentioning

confidence: 98%

Photodynamic therapy: A targeted literature review focussing on outcomes and optimisation in solid organ transplant recipients

Lim

Gordon

2019

Aust J Dermatology

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Squamous cell carcinoma incidence is 65-to 250fold in solid organ transplant recipients, BCC is 10fold and in Australia, rates of skin cancer in solid organ transplant recipients reach 70-82% prevalence within the first 20 years; hence, effective, evidence-based treatment of early and precancerous lesions is an essential tool in dermatological patient care. Photodynamic therapy is used to treat a range of conditions including actinic keratoses, squamous cell carcinoma in situ, superficial basal cell carcinoma and nodular basal cell carcinoma. A literature review was undertaken to examine the outcomes of photodynamic therapy in solid organ transplant recipients and methods of optimising outcomes in solid organ transplant recipients. Study sizes were small and protocols varied widely, so meta-analysis was not possible; however, photodynamic therapy appears to be an acceptable treatment for approved indications in solid organ transplant recipients in whom ongoing surveillance is maintained to ensure clearance and detect recurrence. Methods for improving efficacy were also reviewed for this population. Improved outcomes may be achieved by combining photodynamic therapy with other local methods such as 5-fluorouracil or ablative fractional laser.

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Section: Review Of Photodynamic Therapy Outcomes In Solid Organ Transmentioning

confidence: 98%

Photodynamic therapy: A targeted literature review focussing on outcomes and optimisation in solid organ transplant recipients

Lim

Gordon

2019

Aust J Dermatology

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“…A retrospective chart review over an eight-year period of all patients who were treated in an Australian tertiary dermatology clinic with conventional topical MAL-PDT concluded that this treatment remains an appropriate second-line modality in organ transplant recipients [105].…”

Section: Solid Organ Transplant Recipients and Significantly Immunosumentioning

confidence: 99%

Photodynamic Therapy for Basal Cell Carcinoma: The Clinical Context for Future Research Priorities

Collier

Rhodes

2020

Molecules

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Photodynamic therapy (PDT) is an established treatment option for low-risk basal cell carcinoma (BCC). BCC is the most common human cancer and also a convenient cancer in which to study PDT treatment. This review clarifies challenges to researchers evident from the clinical use of PDT in BCC treatment. It outlines the context of PDT and how PDT treatments for BCC have been developed hitherto. The sections examine the development of systemic and subsequently topical photosensitizers, light delivery regimens, and the use of PDT in different patient populations and subtypes of BCC. The outcomes of topical PDT are discussed in comparison with alternative treatments, and topical PDT applications in combination and adjuvant therapy are considered. The intention is to summarize the clinical relevance and expose areas of research need in the BCC context, ultimately to facilitate improvements in PDT treatment.

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Photodynamic therapy: A real‐world analysis of outcomes of photodynamic therapy in an Australian tertiary dermatology clinic

Cited by 2 publications

References 3 publications

Photodynamic therapy: A targeted literature review focussing on outcomes and optimisation in solid organ transplant recipients

Photodynamic therapy: A targeted literature review focussing on outcomes and optimisation in solid organ transplant recipients

Photodynamic Therapy for Basal Cell Carcinoma: The Clinical Context for Future Research Priorities

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