Photodynamic therapy-a promising treatment of oral mucosal infections

Chen, Ting; Yang, Dan; Lei, Shangxue; Liu, Jiaxin; Song, Yansong; Zhao, Hang; Zeng, Xin; Dan, Hongxia; Chen, Qianming

doi:10.1016/j.pdpdt.2022.103010

Cited by 3 publications

(4 citation statements)

References 133 publications

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“…Systemic and local antimicrobials are the main methods of treating these diseases. However, in conditions of rapid growth and drug resistance, the PDT method is universal [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…As a sensitizer in cells, both natural metabolites—chlorophyll, flavins, porphyrins, bilirubin (endogenous sensitizers), and a wide range of exogenous substances entering the cells—visible light acceptors (dyes, aromatic hydrocarbons) can act [ 5 ]. There is an excitation of the sensitizer, a photochemical reaction occurs, the result of which is the release of singlet oxygen or free radicals [ 6 , 7 ]. A particular case of photosensitized processes is the photodamage of biological systems in the presence of sensitizers with the participation of molecular oxygen—the so-called photodynamic action [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…There is an excitation of the sensitizer, a photochemical reaction occurs, the result of which is the release of singlet oxygen or free radicals [ 6 , 7 ]. A particular case of photosensitized processes is the photodamage of biological systems in the presence of sensitizers with the participation of molecular oxygen—the so-called photodynamic action [ 6 , 7 ]. The substance (photosensitizer) is applied inside the periodontal pocket and is activated by a light source.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of Photodynamic Therapy as Antiseptic Measure for Oral Cavity and Pharynx: A Systematic Review

Sologova,

Petukhova,

Podoplelova

et al. 2023

Dentistry Journal

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Background: The complex traditional treatment of inflammation diseases in oral cavity includes the prescription of antibiotic and antiseptic therapy. This systematic review aims to evaluate the effect of photodynamic therapy as a part of management of inflammatory diseases in oral cavity; Methods: The study is presented in accordance with the preferred reporting points for systematic reviews and meta-analyses (PRISMA). This systematic review was conducted using electronic databases such as Medline PubMed, Scopus and the Cochrane Central Register of Controlled Trials. All the studies in this systematic review, were randomized, the risk of bias 2 (ROB 2) were assessed; Results: Considering the inclusion and exclusion criteria, we included 10 randomized clinical trials, published up to 2023 investigating the application of photodynamic therapy as a part of management of inflammatory diseases in oral cavity. The diode laser was used in the oral cavity in the zone of inflammatory process (gingivitis, mucositis, periimplantitis, marginal periodontitis, abscess, periostitis, osteomyelitis etc.) in nine studies or in the zone before surgical procedures in one study; Conclusion: Based on the results of clinical studies, it can be stated that photodynamic therapy shows good results for operations performed in the oral cavity and pharynx.

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“…Systemic and local antimicrobials are the main methods of treating these diseases. However, in conditions of rapid growth and drug resistance, the PDT method is universal [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effectiveness of Photodynamic Therapy as Antiseptic Measure for Oral Cavity and Pharynx: A Systematic Review

Sologova,

Petukhova,

Podoplelova

et al. 2023

Dentistry Journal

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“…[36,37] Furthermore, it allows for the emission of visible light, enabling the monitoring of the photosensitizer's site and status. [38] Nowadays, PDT has found applications in various fields, including wound care, [39,40] oral medicine, [41,42] and dermatology. [43,44] In a previous study, we developed a series of peptide-AIE (aggregation-induced emission) nanofibers for fluorescent labeling of bacteria and inhibition of wound infections through PDT.…”

Section: Introductionmentioning

confidence: 99%

Peptide‐AIE Nanofibers Functionalized Sutures with Antimicrobial Activity and Subcutaneous Traceability

Cai,

Zhang,

Peng

et al. 2024

Advanced Materials

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As one of the most widely used medical device, sutures face challenges related to surgical site infections (SSIs) and lack of subcutaneous traceability. In the present study, we have developed a facile and effective approach using peptide‐AIE nanofibers (NFs‐K18) to create fluorescent‐traceable antimicrobial sutures, which have been applied to four commercially available sutures. The functionalized sutures of PGAS‐NFs‐K18 and PGLAS‐NFs‐K18 exhibited fluorescence with excellent penetration from 4 mm chicken breasts. They also demonstrated remarkable stability after 24 h of white light illumination and threading through chicken breasts 10 times. These sutures efficiently generated ROS, resulting in a significant suppression of four clinical bacteria, with the highest antimicrobial rate of nearly 100%. Moreover, the sutures exhibited favorable hemocompatibility and biocompatibility. In vivo experiments demonstrated that the optimized PGLAS‐NFs‐K18 suture displayed potent antimicrobial activity against MRSA, effectively inhibiting inflammation and promoting tissue healing in both skin wound and abdominal wall wound models, outperforming the commercially available Coated VICRYL® Plus Antibacterial suture. Importantly, PGLAS‐NFs‐K18 exhibited sensitive subcutaneous traceability, allowing for accurate in situ monitoring of its degradation. We believe that this straightforward strategy offers a new pathway for inhibiting SSIs and monitoring the status of sutures.This article is protected by copyright. All rights reserved

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Hydrogen peroxide preoxidation as a strategy for enhanced antimicrobial photodynamic action against methicillin-resistant Staphylococcus aureus

Sammarro Silva,

Lima,

Dias

et al. 2023

Journal of Water and Health

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Antimicrobial photodynamic treatment (aPDT) is a photooxidative process based on the excitation of a photosensitizer (PS) in the presence of molecular oxygen, under specific wavelengths of light. It is a promising method for advanced treatment of water and wastewater, particularly targeting disinfection challenges, such as antibiotic-resistant bacteria (ARB). Research in improved aPDT has been exploring new PS materials, and additives in general. Hydrogen peroxide (H2O2) a widely applied disinfectant, mostly in the food industry and clinical settings, present environmentally negligible residuals at the usually applied concentrations, making it friendly for the water and wastewater sectors. Here, we explored the effects of preoxidation with H2O2 followed by blue light-mediated (450 nm) aPDT using curcumin (a natural-based PS) against methicillin-resistant Staphylococcus aureus (MRSA). Results of the sequential treatment pointed to a slight hampering in aPDT efficiency at very low H2O2 concentrations, followed by an increasing cooperative effect up to a deleterious point (≥7 log10 inactivation in CFU mL–1), suggesting a synergistic interaction of preoxidation and aPDT. The increased performance in H2O2-pretreated aPDT encourages studies of optimal operational conditions for the assisted technology and describes potentials for using the described strategy to tackle the issue of ARB spread.

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Photodynamic therapy-a promising treatment of oral mucosal infections

Cited by 3 publications

References 133 publications

Effectiveness of Photodynamic Therapy as Antiseptic Measure for Oral Cavity and Pharynx: A Systematic Review

Effectiveness of Photodynamic Therapy as Antiseptic Measure for Oral Cavity and Pharynx: A Systematic Review

Peptide‐AIE Nanofibers Functionalized Sutures with Antimicrobial Activity and Subcutaneous Traceability

Hydrogen peroxide preoxidation as a strategy for enhanced antimicrobial photodynamic action against methicillin-resistant Staphylococcus aureus

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