Photodynamic therapy: a new approach to the treatment of Nontuberculous Mycobacterial skin and soft tissue infections

Wang, Xiao; Wang, Xiaoyu; Lei, Xia; He, Yongqing; Xiao, Tianzhen

doi:10.1016/j.pdpdt.2023.103645

Cited by 3 publications

(1 citation statement)

References 83 publications

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“…Perez-Laguna et al [85] have reviewed using aPDT in treating SSTI for Gram-positive and Gram-negative microorganisms, yeasts, dermatophytes, and moulds. It has proved effective in treating cutaneous leishmaniasis [86], cutaneous nontuberculous mycobacteriosis [87 ▪ ], and chronic skin ulcers infected with Pseudomonas aeruginosa [88].…”

Section: Introductionmentioning

confidence: 99%

Current challenges in acute bacterial skin infection management

Burillo,

Pulido-Pérez,

Bouza

2024

Current Opinion in Infectious Diseases

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Purpose of review There are aspects of skin and soft tissue infections (SSTIs) that remain unresolved, such as current numbers, classification criteria, how best to define severity and predict the outcome, what diagnostic tests to perform, what new treatment options are available, or what the duration of antibiotic treatment should be. We have reviewed the literature over the last 18 months to clarify these issues and provide our opinion. Recent findings SSTIs are common and among the top 10 most frequent infections worldwide. They represent a burden on the healthcare system and have a major impact on the quality of life of patients. Regarding classification, the Infectious Diseases Society of America (IDSA) provides a practical guide that distinguishes between uncomplicated and complicated infections, acute and chronic wound infections, and necrotising and nonnecrotizing infections based on skin extension and tissue necrosis. With new microbiological and imaging diagnostic techniques, SSTIs can now be better diagnosed. New PCR techniques are available, and mass spectrometry can be applied to samples collected in liquid transport media. Moreover, new treatment methods such as photodynamic therapy, reactive oxygen, and phages are emerging. SSTI patients can be treated with shorter antibiotic courses if they receive an active drug with good tissue penetration. Antibiotic treatment in necrotizing infections can be shortened to 48 h after the last debridement. Summary SSTIs remain a challenge regarding rapid and accurate diagnosis and clinical management.

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Section: Introductionmentioning

confidence: 99%

Current challenges in acute bacterial skin infection management

Burillo,

Pulido-Pérez,

Bouza

2024

Current Opinion in Infectious Diseases

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Nonperipherally and peripherally substituted water‐soluble magnesium (II) phthalocyanines and their DNA binding, nuclease activities

Barut,

Seyhan,

Keleş

et al. 2024

Applied Organom Chemis

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In this study, magnesium (II) phthalocyanines (2a, 3a) and their water‐soluble derivatives (2b, 3b) were synthesized via multistep reactions. The structures of these phthalocyanines were identified by FT‐IR, NMR, MALDI‐TOF, and UV–Vis spectroscopy. The ct‐DNA binding (UV–Vis absorption, competitive EB binding, and agarose electrophoresis studies) and supercoiled plasmid DNA nuclease properties (hydrolytic, photonuclease, oxidative nuclease, and photooxidative nuclease) of the water‐soluble compounds were investigated using different methods. The DNA binding constant (Kb) values of 2b and 3b were calculated as 8.45 ± (0.25) × 104 and 7.71 ± (0.13) × 104 M−1 at 25°C, respectively. The results showed that 2b had a stronger ct‐DNA binding effect than 3b according to Kb and r values. The DNA nuclease studies claimed that both compounds indicated photonuclease activity on plasmid DNA depending on the light dose. Additionally, 2b had a higher photonuclease capacity than 3b. All of these results showed that 2b had promising potential as a photosensitizer agent for photodynamic therapy.

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Investigating cutaneous tuberculosis and nontuberculous mycobacterial infections a Department of Dermatology, Beijing, China: a comprehensive clinicopathological analysis

Wang,

Jia,

et al. 2024

Front. Cell. Infect. Microbiol.

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BackgroundCutaneous tuberculosis (CTB) and nontuberculous mycobacteria (NTM) infections present considerable diagnostic and therapeutic challenges. This study aims to provide a comprehensive clinicopathological analysis of CTB and NTM infections.MethodsWe conducted a retrospective analysis of 103 patients diagnosed with cutaneous tuberculosis (CTB) and nontuberculous mycobacteria (NTM) infections at a Beijing dermatology department from January 2000 to January 2024. Demographic, clinical, histological, and laboratory finding data were collected. Diagnostic methods and histopathological examination were recorded. Treatment regimens and outcomes were reviewed. Descriptive statistics were used to summarize demographic and clinical data, and continuous variables expressed as means and standard deviations (SD), and categorical variables as frequencies and percentages. Statistical analyses were conducted using SPSS version 25.0.ResultsThe cohort included 103 patients (40.8% males and 59.2% females), with a mean age of 51.86 years. Common clinical manifestations included nodules (97.1%), erythema (74.8%), and plaques (68.9%). Histological examination revealed hyperkeratosis (68.9%), parakeratosis (23.3%), and extensive neutrophil infiltration (95.1%) were observed. Acid fast bacteria (AFB) stains and nucleic acid tests exhibited respective positivity rates of 39.6% and 52.3%, respectively. Most patients were treated with a combination of three drugs; 77.1% of patients showed improvement, with the cure rate for CTB being 20.0%.DiscussionThis study highlights the diverse clinical and histological presentations of CTB and NTM infections, emphasizing the need for comprehensive diagnostic approaches. The variability in treatment regimens reflects the complex management of these infections.ConclusionThe implementation of advanced molecular techniques and standardized treatment protocols is imperative for enhancing diagnostic precision and therapeutic outcomes.

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Photodynamic therapy: a new approach to the treatment of Nontuberculous Mycobacterial skin and soft tissue infections

Cited by 3 publications

References 83 publications

Current challenges in acute bacterial skin infection management

Current challenges in acute bacterial skin infection management

Nonperipherally and peripherally substituted water‐soluble magnesium (II) phthalocyanines and their DNA binding, nuclease activities

Investigating cutaneous tuberculosis and nontuberculous mycobacterial infections a Department of Dermatology, Beijing, China: a comprehensive clinicopathological analysis

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