Photodynamic Therapy: A Clinical Consensus Guide

Ozog, David M.; Rkein, Ali M.; Fabi, Sabrina G.; Gold, Michael H.; Goldman, Mitchel P.; Lowe, Nicholas J.; Martin, George M.; Munavalli, Girish S.

doi:10.1097/dss.0000000000000800

Cited by 206 publications

(129 citation statements)

References 75 publications

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“…In PDT, photosensitizers (PSs) in tumor tissue absorb externally applied light and transfer the energy to ground state molecular oxygen to produce singlet oxygen ( 1 O 2 ), which is toxic to cells and ultimately induces localized cell death within the area of irradiation [ 11 , 12 , 13 ]. PDT is a promising treatment strategy for certain types of cancers and skin conditions [ 14 ] because it is less invasive than surgical options [ 15 ], has fewer side effects than radiation or chemotherapy [ 13 , 16 ], and has been shown to stimulate antitumor immune responses [ 17 , 18 ]. Despite these promising benefits of PDT, its widespread clinical use is met with three key limitations.…”

Section: Introductionmentioning

confidence: 99%

Evaluating Nanoshells and a Potent Biladiene Photosensitizer for Dual Photothermal and Photodynamic Therapy of Triple Negative Breast Cancer Cells

et al. 2018

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Light-activated therapies are ideal for treating cancer because they are non-invasive and highly specific to the area of light application. Photothermal therapy (PTT) and photodynamic therapy (PDT) are two types of light-activated therapies that show great promise for treating solid tumors. In PTT, nanoparticles embedded within tumors emit heat in response to laser light that induces cancer cell death. In PDT, photosensitizers introduced to the diseased tissue transfer the absorbed light energy to nearby ground state molecular oxygen to produce singlet oxygen, which is a potent reactive oxygen species (ROS) that is toxic to cancer cells. Although PTT and PDT have been extensively evaluated as independent therapeutic strategies, they each face limitations that hinder their overall success. To overcome these limitations, we evaluated a dual PTT/PDT strategy for treatment of triple negative breast cancer (TNBC) cells mediated by a powerful combination of silica core/gold shell nanoshells (NSs) and palladium 10,10-dimethyl-5,15-bis(pentafluorophenyl)biladiene-based (Pd[DMBil1]-PEG750) photosensitizers (PSs), which enable PTT and PDT, respectively. We found that dual therapy works synergistically to induce more cell death than either therapy alone. Further, we determined that low doses of light can be applied in this approach to primarily induce apoptotic cell death, which is vastly preferred over necrotic cell death. Together, our results show that dual PTT/PDT using silica core/gold shell NSs and Pd[DMBil1]-PEG750 PSs is a comprehensive therapeutic strategy to non-invasively induce apoptotic cancer cell death.

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Section: Introductionmentioning

confidence: 99%

Evaluating Nanoshells and a Potent Biladiene Photosensitizer for Dual Photothermal and Photodynamic Therapy of Triple Negative Breast Cancer Cells

et al. 2018

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“…ALA is endogenously converted into protoporphyrin IX, a photosensitizing molecule, which leads to the formation of reactive oxygen species after exposure to an appropriate wavelength (400-410 nm, 635 nm) (40). Besides ALA, one of the most used agents is its derivative, methyl aminolevulinate (MAL) (41). Other photosensitizers are phenothiazines such as toluidine blue and methylene blue (620-700 nm) that are especially used in dentistry (39).…”

Section: Photodynamic Therapya Promising Therapymentioning

confidence: 99%

Photodynamic therapy as a new therapeutic approach of oral lichen planus

Tocut¹,

Mitran²,

Mitran³

et al. 2019

JMMS

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Oral lichen planus (OLP) is a chronic, immunologically mediated disease, defined by periods of exacerbation and quiescence. The disease is associated with a low mortality risk, but in some instances, morbidity can be important, especially in extensive, erosive forms, with a significant impact on the quality of life. OLP is a chronic T-cell mediated inflammatory disease involving the oral cavity, the most common lesions being located on the oral mucosa, tongue and gums. Its etiology remains in part unknown, but several factors proved to be involved in the development of the disease (drugs, dental materials, infectious agents, psychological factors, autoimmunity and genetic predisposition). The therapeutic approach should take into account the type of lesion and the extent of the disease, as well as the possible adverse effects. Although several therapies are available, OLP treatment still remains a challenge. Photodynamic therapy (PDT) is widely used in dermatology, finding applicability in the treatment of an increasing number of conditions. Recent research has shown the role of PDT in the treatment of OLP. It is a minimally invasive therapy with few side effects and promising results. Keywords  oral lichen planus, photosensitizer, therapy Highlights  The therapeutic approach in the OLP remains a challenge; although many therapies are available, none of them can still be considered the ideal therapeutic approach.  PDT seems to be a promising therapy, but with heterogeneous results due to lack of standardization (the available studies using different sources of light, wavelengths and photosensitizers).

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“…The idea behind PDT as a treatment for cancer lies in the use of two components (a photosensitizing agent and electromagnetic radiation) that are each harmless on their own, but in combination can be cytotoxic . The main advantage of this type of therapy is that the photosensitizing agent can be activated in a directed and focused manner by means of a low‐energy laser applied in a specific area in which the tumor cells to be treated are located.…”

Section: Introductionmentioning

confidence: 99%

Rhodium Nanoparticles as a Novel Photosensitizing Agent in Photodynamic Therapy against Cancer

Machuca

García-Calvo

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et al. 2020

Chemistry A European J

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Photodynamic therapy (PDT) is a promising alternative treatment for different types of cancer due to its high selectivity, which prevents healthy tissues from being damaged. The use of nanomaterials in PDT has several advantages over classical photosensitizing agents, due to their unique properties and their capacity for functionalization. Especially interesting is the use of metallic nanoparticles, which are capable of absorbing electromagnetic radiation and either transferring this energy to oxygen molecules for the generation of reactive oxygen species (ROS) or dissipating it as heat. Although previous reports have demonstrated the capacity of Rh derivatives to serve as anti‐tumor drugs, to the best of our knowledge there have been no studies on the potential use of small‐sized Rh nanoparticles as photosensitizers in PDT. In this study, 5 nm Rh nanoparticles have been synthesized and their potential in PDT has been evaluated. The results show that treatment with Rh nanoparticles followed by NIR irradiation induces apoptosis in cancer cells through a p53‐independent mechanism.

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Photodynamic Therapy: A Clinical Consensus Guide

Abstract: The ASDS consensus document on PDT will be helpful for educating members on safe and effective PDT for a variety of indications.

Cited by 206 publications

References 75 publications

Evaluating Nanoshells and a Potent Biladiene Photosensitizer for Dual Photothermal and Photodynamic Therapy of Triple Negative Breast Cancer Cells

Evaluating Nanoshells and a Potent Biladiene Photosensitizer for Dual Photothermal and Photodynamic Therapy of Triple Negative Breast Cancer Cells

Photodynamic therapy as a new therapeutic approach of oral lichen planus

Rhodium Nanoparticles as a Novel Photosensitizing Agent in Photodynamic Therapy against Cancer

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