Photodynamic therapy: a better treatment for widespread Bowen's disease

Robinson, Philip; Carruth, J. A. S.; Fairris, G.M.

doi:10.1111/j.1365-2133.1988.tb07101.x

Cited by 76 publications

(20 citation statements)

References 2 publications

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“…Topical ALA application and subsequent exposure to polychromatic or laser light was successfully used to treat plaque-stage cutaneous T-cell lymphoma. 29 In another study that used laser light, 2 of 4 lesions were effectively treated. 38 However, the apparent clinical cure was not confirmed histologically.…”

mentioning

confidence: 99%

“…In several patients, successful treatment of Bowen disease (BD) with porfimer sodium and an argon-PDL was described. [28][29][30] Bowen disease also shows a good initial response to PDT with ALA, but long-term results vary considerably. Rates of CR of 90% and 100% 6,24,28 could not be confirmed in subsequent studies, 19 and our own results suggest a CR in only 30% to 50% (Table 2; Figure 4).…”

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confidence: 99%

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Photodynamic Therapy in Dermatology

Fritsch

Goerz²,

Ruzicka³

1998

Arch Dermatol

251

173

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confidence: 99%

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confidence: 99%

Photodynamic Therapy in Dermatology

Fritsch

Goerz²,

Ruzicka³

1998

Arch Dermatol

251

173

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“…Even repeated PDT treatment yielded a CR rate of only 50-70% [10,13]. Incomplete response of BD may be due to the thickened epithelial layer with reduced ALA penetration [10,11,13,15,36,37,39,40,47,48,[51][52][53].…”

Section: Bowen's Diseasementioning

confidence: 99%

“…(fig. 2) Successful treatment of BD with porfimer sodium and an argon-PDL has been described in several patients [37,40,51]. BD also shows a good initial response to PDT with ALA, but long-term results vary considerably (CR rate:…”

Section: Summary Of Studies On Pdt In Dermatologymentioning

confidence: 99%

Photodynamic Diagnosis and Therapy in Dermatology

Fritsch

Lang

Neuse

et al. 1998

Skin Pharmacol Physiol

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The topical application of δ-aminolevulinic acid (ALA) induces porphyrin formation in the skin, preferentially in tumor tissues. Irradiation of the porphyrin-enriched tumor tissue with Wood’s light leads to emission of a brick-red fluorescence. This principle may be used as a diagnostic procedure which may be termed photodynamic diagnosis (PDD). In ALA-PDD, tumors and precancerous lesions of the skin reveal a homogeneous, intensive red fluorescence. Psoriatic lesions also show a strong but inhomogeneous porphyrin fluorescence. ALA-induced porphyrin fluorescence in preoperative planning is a valuable method to determine the peripheral borders of a given tumor. The histopathological extensions of the tumors correlate well with the borders detected by the tumor-specific fluorescence. The main indications of PDD are the delineation of clinically ill-defined skin tumors and the control of the efficacy of other tumor therapies. Photodynamic therapy (PDT) utilizes exogenously applied or endogenously formed photosensitizers and their activation by light to induce cell death via formation of singlet oxygen and other free radicals. PDT is highly efficient in the treatment of solar keratoses and superficial basal cell carcinomas. Initial squamous cell carcinomas also show good response to ALA-PDT. During the last decade, numerous studies on PDT for dermatologic diseases were published, the more important ones are reviewed here.

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“…It can be applied safely after other modalities of treatment such as radiation or chemotherapy (Dougherty, 1984;. The results of clinical studies demonstrate that superficial therapy can be very effective for small superficial tumours (Dougherty, 1984;Kato et al, 1986;Parrish, 1983;Robinson et al, 1988;Unsold et al, 1990) and that interstitial therapy shows promise for the treatment of small tumours, but should also allow treatment of non-superficial tumours (Barr et al, 1990;Monnier et al, 1990).…”

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Interstitial photodynamic therapy. Clinical experience with diffusing fibres in the treatment of cutaneous and subcutaneous tumours

Lowdell

Ash²,

Driver³

et al. 1993

Br J Cancer

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SummaryInterstitial photodynamic therapy has a number of potential advantages over superficial treatment. We have treated 50 subcutaneous and cutaneous tumours interstitially, in nine patients. An additional 22 tumours in the same patients, were treated by superficial PDT. Patients received 1.5 -2.0 mg kg of polyhaematoporphyrin and 72 h later underwent treatment using a copper vapour dye laser producing red light at 630 nm.All interstitial treatments were delivered using cylindrical diffusing fibres and a wide range of light doses (5-1500 J cm-3). The complete response rate for all tumours treated interstitially was 52%, rising to 81% in those patients who received 2.0 mg kg-' PHP and light doses in excess of 500 J cm-3. The overall incidence of skin necrosis was 32% and was 79% in those treated with light doses of greater than 500 J cm-3. The incidence of skin necrosis with interstitial PDT is lower than that seen with superficial photodynamic therapy but higher volumetric light doses are required to produce tumour complete responses. All treatments were well tolerated and volumes of tumour up to 60 cm3 were successfully treated. The penetration depth of 630 nm light in human breast cancer tissue was determined as 4 mm. Little true tumour tissue selectivity was detected by analysis of porphyrin levels in biopsy material.

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Photodynamic therapy: a better treatment for widespread Bowen's disease

Cited by 76 publications

References 2 publications

Photodynamic Therapy in Dermatology

Photodynamic Therapy in Dermatology

Photodynamic Diagnosis and Therapy in Dermatology

Interstitial photodynamic therapy. Clinical experience with diffusing fibres in the treatment of cutaneous and subcutaneous tumours

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