Photodynamic Therapy

MacCormack, Mollie A.

doi:10.1016/j.yadr.2006.09.008

Cited by 48 publications

(42 citation statements)

References 165 publications

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“…We expect this could increase the efficacy of such treatments. Most photosensitizers of photodynamic therapy have to be activated using light in the nearinfrared range [1][2][3]. However, porphyrin compounds, the drugs that are most commonly used in photodynamic therapy, exhibit stronger absorption and excitation in the range of 400-600 nm [22][23][24].…”

Section: Discussionmentioning

confidence: 99%

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In Vivo Photoactivation Without “Light”: Use of Cherenkov Radiation to Overcome the Penetration Limit of Light

et al. 2011

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Purpose: The poor tissue penetration of visible light has been a major barrier for optical imaging, photoactivatable conversions, and photodynamic therapy for in vivo targets with depths beyond 10 mm. In this report, as a proof-of-concept, we demonstrated that a positron emission tomography (PET) radiotracer, 2-deoxy-2-[ 18 F]fluoro-D-glucose ( 18 FDG), could be used as an alternative light source for photoactivation. Procedures: We utilized 18 FDG, which is a metabolic activity-based PET probe, as a source of light to photoactivate caged luciferin in a breast cancer animal model expressing luciferase. Results: Bioluminescence produced from luciferin allowed for the real-time monitoring of Cherenkov radiation-promoted uncaging of the substrate. Conclusion: The proposed method may provide a very important option for in vivo photoactivation, in particular for activation of photosensitizers for photodynamic therapy and eventually for combining radioisotope therapy and photodynamic therapy.

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Section: Discussionmentioning

confidence: 99%

“…However, the poor tissue penetrating ability of light undoubtedly limits its broad application in vivo [1][2][3]. To address light penetration issues, long wavelength light sources are often used, but this can come as a tradeoff with excitation losses due to poor overlap with absorption spectra.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Photoactivation Without “Light”: Use of Cherenkov Radiation to Overcome the Penetration Limit of Light

et al. 2011

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“…Unfortunately, there are no PDT agents that meet all of these requirements [24]. Limited ability of many agents to reach the target tissue can lead to severe side-effects after exposure to light [25][26][27]. Activation energies of some agents extort prolonged exposure time.…”

Section: Nanomaterials In Photodynamic Medicinementioning

confidence: 99%

Nanotechnology for biomedical applications - enhancement of photodynamic activity by nanomaterials

Ulatowska-Jarża¹,

Pucińska²,

Wysocka-Król³

et al. 2011

Bulletin of the Polish Academy of Sciences: Technical Sciences

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Abstract. Over the last two decades nanotechnology has become one of the most dynamically evolving field of research. The unique properties of nanomaterials, not disclosing at microscale, are examined and exploited to extend our understanding of the interactions taking place at atomic or molecular level. Those findings affect research in many areas, like e.g. alternative energy sources, electronics, physics and medicine. In this paper, the possibility of using nanomaterials for the enhancement of photodynamic activity, is discussed. A brief review on drug-delivery facilitating nanomaterials, regarding their characteristic features, is presented. An exemplary application of silver-doped nanomaterials for enhancement of photodynamic properties of two photosensitizers: Photolon and Protoporphyrin IX, is described. Influence of silver-doped nanomaterials addition on the fluorescence intensity of photosensitizers immobilized in silica-titania (SiO2-TiO2) sol was examined via VIS spectroscopy. Influence of sonication on the fluorescence enhancement was also investigated. It was demonstrated that the fluorescence enhancement of photosensitizers depends on the concentration of both: photosensitizer and silver-doped nanoparticles.

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“…1 In the United States, the combination of 5-aminolevulinate ͑ALA͒ and blue light ͑417 nm͒ was approved in 1999 for AK, while in Europe, the combination of methyl-aminolevulinate and red light ͑ϳ630 nm͒ is now widely employed for both AK and nonmelanoma skin cancers. 2,3 However, the question of how long before irradiation these precursor drugs must be applied in order to obtain a useful level of photosensitizer and a satisfactory response to PDT has not been completely answered.…”

Section: Introductionmentioning

confidence: 99%

Noninvasive fluorescence monitoring of protoporphyrin IX production and clinical outcomes in actinic keratoses following short-contact application of 5-aminolevulinate

et al. 2010

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Abstract. Topical 5-aminolevulinic acid ͑ALA͒ is widely used in photodynamic therapy ͑PDT͒ of actinic keratoses ͑AK͒, a type of premalignant skin lesion. However, the optimal time between ALA application and exposure to light has not been carefully investigated. Our objective is to study the kinetics of protoporphyrin IX ͑PpIX͒ accumulation in AK after short contact ALA and relate this to erythemal responses. Using a noninvasive dosimeter, PpIX fluorescence measurements ͑5 replicates͒ were taken at 20-min intervals for 2 h following ALA application, in 63 AK in 20 patients. Data were analyzed for maximal fluorescent signal obtained, kinetic slope, and changes in erythema. Our results show that PpIX accumulation was linear over time, becoming statistically higher than background in 48% of all lesions by 20 min, 92% of lesions by 1 h, and 100% of lesions by 2 h. PpIX accumulation was roughly correlated with changes in lesional erythema post-PDT. We conclude that significant amounts of PpIX are produced in all AK lesions by 2 h. The linear kinetics of accumulation suggest that shorter ALA application times may be efficacious in many patients. Noninvasive fluorescence monitoring of PpIX may be useful to delineate areas of high PpIX accumulation within precancerous areas of the skin. © 2010 Society of Photo-Optical Instrumentation Engineers.

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Photodynamic Therapy

Cited by 48 publications

References 165 publications

In Vivo Photoactivation Without “Light”: Use of Cherenkov Radiation to Overcome the Penetration Limit of Light

In Vivo Photoactivation Without “Light”: Use of Cherenkov Radiation to Overcome the Penetration Limit of Light

Nanotechnology for biomedical applications - enhancement of photodynamic activity by nanomaterials

Noninvasive fluorescence monitoring of protoporphyrin IX production and clinical outcomes in actinic keratoses following short-contact application of 5-aminolevulinate

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