Photodynamic inactivation with curcumin and silver nanoparticles hinders Pseudomonas aeruginosa planktonic and biofilm formation: evaluation of glutathione peroxidase activity and ROS production

Ghasemi, Mehrangiz; Khorsandi, Khatereh; Kianmehr, Zahra

doi:10.1007/s11274-021-03104-4

Cited by 16 publications

(12 citation statements)

References 29 publications

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“…Previous studies have shown that some bacteria show resistance against PDI 31,49,56 . The increase in bacterial inactivation of MRSA and MDR E. coli by PpIX-AgNPs following light irradiation is consistent with the patterns recorded in literature 19,[22][23][24][25]37 . Also, other studies have reported complete elimination of MRSA and E. coli using AgNPs only; however, MIC are at least 5 µg/mL depending on the physiochemical properties of the examined AgNPs 25, 54, 57 .…”

Section: Bacteria Inactivationsupporting

confidence: 91%

“…Interestingly, neither PpIX-AgNPs nor PEI-PpIX-AgNPs show PDT effect against HeLa cells, most likely because most of the 1 O 2 generated by the PS reacts with the surface of AgNPs. Similar "quenching" effects have been observed in other NPs carrying PSs 23,24,37,61 . Control experiments also demonstrate that the concentration of Ag + used to eliminate bacteria is not toxic to HeLa cells.…”

Section: Cytotoxicity In Mammalian Cellssupporting

confidence: 78%

“…Recent studies have shown that the PS-AgNP combination have synergistic antimicrobial effect. These studies demonstrated that the synergistic antimicrobial effect of PS-AgNP conjugates in bacteria (non-resistant) is concentration dependent and contributed by the oxidative stress due to enhanced ROS production 19,[22][23][24][25] . However, there is a lack of understanding on the impact of the light-mediated release of Ag + in these systems, which is also a critical parameter that contributes to the antibacterial synergy in PSs and AgNPs conjugates.…”

Section: Introductionmentioning

confidence: 96%

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Influence of silver ion release on the inactivation of antibiotic resistant bacteria using light-activated silver nanoparticles

et al. 2022

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Section: Bacteria Inactivationsupporting

confidence: 91%

Section: Cytotoxicity In Mammalian Cellssupporting

confidence: 78%

Section: Introductionmentioning

confidence: 96%

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Influence of silver ion release on the inactivation of antibiotic resistant bacteria using light-activated silver nanoparticles

et al. 2022

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“…Curcumin absorbs blue light in the range of 455-460 nm and can be employed as an effective photosensitizer to promote the success of photodynamic processing [19]. This photosensitizing property has been exploited to induce phototoxicity in Gram-positive and -negative bacterial cells under blue light irradiation [50,71]. It is noteworthy to mention that Gram-positive bacteria are known to be more sensitive and are easily killed by photosensitizers compared to Gram-negative bacteria [50].…”

Section: Phototoxicitymentioning

confidence: 99%

The Natural Product Curcumin as an Antibacterial Agent: Current Achievements and Problems

Dai

Lin

et al. 2022

Antioxidants

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The rapid spread of antibiotic resistance and lack of effective drugs for treating infections caused by multi-drug resistant bacteria in animal and human medicine have forced us to find new antibacterial strategies. Natural products have served as powerful therapeutics against bacterial infection and are still an important source for the discovery of novel antibacterial drugs. Curcumin, an important constituent of turmeric, is considered safe for oral consumption to treat bacterial infections. Many studies showed that curcumin exhibited antibacterial activities against Gram-negative and Gram-positive bacteria. The antibacterial action of curcumin involves the disruption of the bacterial membrane, inhibition of the production of bacterial virulence factors and biofilm formation, and the induction of oxidative stress. These characteristics also contribute to explain how curcumin acts a broad-spectrum antibacterial adjuvant, which was evidenced by the markedly additive or synergistical effects with various types of conventional antibiotics or non-antibiotic compounds. In this review, we summarize the antibacterial properties, underlying molecular mechanism of curcumin, and discuss its combination use, nano-formulations, safety, and current challenges towards development as an antibacterial agent. We hope that this review provides valuable insight, stimulates broader discussions, and spurs further developments around this promising natural product.

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“…Skin wounds, especially open skin wounds, are often associated with bacterial infections that can cause serious complications and impede the wound healing [184][185][186]. NP-based PDT have a high potential for wound sterilization through the production of ROS mediated by oxidative damage to biomolecules (such as proteins, nucleic acids, and lipids) of pathogenic microorganisms [187,188]. Different types of NP base PS with antibacterial properties have been used to reduce bacterial infections [189,190].…”

Section: Technical Advances In Photodynamic Therapymentioning

confidence: 99%

Accelerating skin regeneration and wound healing by controlled ROS from photodynamic treatment

et al. 2022

Self Cite

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Cellular metabolisms produce reactive oxygen species (ROS) which are essential for cellular signaling pathways and physiological functions. Nevertheless, ROS act as “double-edged swords” that have an unstable redox balance between ROS production and removal. A little raise of ROS results in cell proliferation enhancement, survival, and soft immune responses, while a high level of ROS could lead to cellular damage consequently protein, nucleic acid, and lipid damages and finally cell death. ROS play an important role in various pathological circumstances. On the contrary, ROS can show selective toxicity which is used against cancer cells and pathogens. Photodynamic therapy (PDT) is based on three important components including a photosensitizer (PS), oxygen, and light. Upon excitation of the PS at a specific wavelength, the PDT process begins which leads to ROS generation. ROS produced during PDT could induce two different pathways. If PDT produces control and low ROS, it can lead to cell proliferation and differentiation. However, excess production of ROS by PDT causes cellular photo damage which is the main mechanism used in cancer treatment. This review summarizes the functions of ROS in living systems and describes role of PDT in production of controllable ROS and finally a special focus on current ROS-generating therapeutic protocols for regeneration and wound healing.

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Photodynamic inactivation with curcumin and silver nanoparticles hinders Pseudomonas aeruginosa planktonic and biofilm formation: evaluation of glutathione peroxidase activity and ROS production

Cited by 16 publications

References 29 publications

Influence of silver ion release on the inactivation of antibiotic resistant bacteria using light-activated silver nanoparticles

Influence of silver ion release on the inactivation of antibiotic resistant bacteria using light-activated silver nanoparticles

The Natural Product Curcumin as an Antibacterial Agent: Current Achievements and Problems

Accelerating skin regeneration and wound healing by controlled ROS from photodynamic treatment

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