Photodynamic inactivation of viruses using upconversion nanoparticles

Lim, Meng Earn; Lee, Yen‐Ling; Zhang, Yong; Chu, Justin Jang Hann

doi:10.1016/j.biomaterials.2011.11.033

Cited by 167 publications

(124 citation statements)

References 19 publications

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“…One potential therapeutic application of UCNPs is PDT [113][114][115][116][117]. Ln III -doped UCNPs have been explored as the initial chromophore in a multi-photon sequence of events leading to singlet oxygen generation for destroying diseased tissue or pathogens.…”

Section: Uncaging Using Upconversion Nanoparticles (A) Introduction Tmentioning

confidence: 99%

“…Irradiation at 980 nm resulted in cytotoxic effects from the singlet O 2 generated. In another recent study, the effect of PDT triggered by 980 nm excitation of NaYF 4 :Yb/Er UCNPs with Zn(II) phthalocyanine on the surface was shown to be effective in inactivating viruses [116]. Potential uses of similar UCNP/dye combinations for PDT in this manner have been explored with small animal models and demonstrated some success in tumour reduction and lifespan extension in Balb/c mouse models [115].…”

Section: Uncaging Using Upconversion Nanoparticles (A) Introduction Tmentioning

confidence: 99%

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Multi-photon excitation in uncaging the small molecule bioregulator nitric oxide

Garcia

Zhang

Ford

2013

Phil. Trans. R. Soc. A.

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Multi-photon excitation allows one to use tissue transmitting near-infrared (NIR) light to access excited states with energies corresponding to single-photon excitation in the visible or ultraviolet wavelength ranges. Here, we present an overview of the application of both simultaneous and sequential multi-photon excitation in studies directed towards the photochemical delivery (‘uncaging’) of bioactive small molecules such as nitric oxide (NO) to physiological targets. Particular focus will be directed towards the use of dyes with high two-photon absorption cross sections and lanthanide ion-doped upconverting nanoparticles as sensitizers to facilitate the uncaging of NO using NIR excitation.

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Section: Uncaging Using Upconversion Nanoparticles (A) Introduction Tmentioning

confidence: 99%

Section: Uncaging Using Upconversion Nanoparticles (A) Introduction Tmentioning

confidence: 99%

Multi-photon excitation in uncaging the small molecule bioregulator nitric oxide

Garcia

Zhang

Ford

2013

Phil. Trans. R. Soc. A.

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“…Finally, recent studies have proposed that rare earth mineral nanoparticles (the so-called upconversion nanoparticles, consisting of sodium yttrium fluoride (NaYF 4 ) codoped with ytterbium and erbium ions [80]) can be used to transduce near-infrared light into required short wavelength light for activate powerful photosensitizers and for a better penetration of PS into the tissues. …”

Section: Photomedicine -Advances In Clinical Practicementioning

confidence: 99%

Can Nanotechnology Shine a New Light on Antimicrobial Photodynamic Therapies?

Bloise¹,

Minzioni²,

Imbriani³

et al. 2017

Photomedicine - Advances in Clinical Practice

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Recent developments in light-controlled therapies (e.g., photodynamic and photothermal therapies) provide promising strategies to prevent and suppress bacterial infections, which are a leading cause of morbidity and mortality. Antibacterial photodynamic therapy (aPDT) has drawn increasing attention from the scientific society for its potential to kill multidrug-resistant pathogenic bacteria and for its low tendency to induce drug resistance. In this chapter, we summarize the mechanism of action of aPDT, the photosensitizers, as well the current developments in terms of treating Gram-positive and Gram-negative bacteria. The chapter also describes the recent progress relating to photomedicine for preventing bacterial infections and biofilm formation. We focus on the laser device used in aPDT and on the light-treatment parameters that may have a strong impact on the results of aPDT experiments. In the last part of this chapter, we survey on the various nanoparticles delivering photoactive molecules, and photoactive-nanoparticles that can potentially enhance the antimicrobial action of aPDT.

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“…The properties of RE doped UCNPs include high chemical stability, low toxicity, and higher signal-to-noise ratio than quantum dots and organic dye markers, especially in vivo [1,2]. Consequently, these NPs have attracted much attention for their potential applications in optical communications, optoelectronic devices, flat panel displays, photodynamic therapy, and biosensors [3][4][5][6][7][8][9][10]. Several RE dopants, such as Er 3+ [11][12][13][14][15][16], Eu 3+ [17][18][19], Sm 3+ [20,21], Tm 3+ [22], and Ho 3+ [23], have been utilized as luminescent centers.…”

Section: Introductionmentioning

confidence: 99%