Photodynamic effects of anthracyclin derivatives on squamous cell carcinoma cell lines of the head and neck

Lippert, B. M.; Teymoortash, Afshin; Külkens, Christoph; Folz, Benedikt J.; Werner, Jochen A.

doi:10.1002/lsm.20040

Cited by 7 publications

(9 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lippert et al 8 reported on the effect of combined application of ADR and laser light irradiation on various squamous cell carcinoma cell lines and found a synergetic effect by a factor of 2, which was attributed to photodynamic activity of ADR. Lou et al 9 reported on the reversal of the resistance of breast cancer cells to ADR by the application of the so-called photochemical internalization (PCI) method 10 , which involves release of endocytosed macromolecular agents into the cytosol after photochemically-induced rupture of the endocytic vesicles.…”

Section: Discussionmentioning

confidence: 98%

Improved tumour response by laser light treatment

et al. 2008

View full text Add to dashboard Cite

Multidrug resistance (MDR) poses a serious barrier to the efficacy of clinical treatment of human cancers with chemotherapeutic drugs. This barrier might be reduced and eventually overcome by the simultaneous application of two or more treatment modalities. This study reports on the synergetic effect of combined application of laser light and cytostatic drugs to induce an improved tumour response in MDR cancer cells. The MDR breast cancer cell line MaTu/ADR, resistant to the drug adriamycin (ADR), was treated with a combination of ADR (125-1000 ng/ml) and laser light (488 nm with a total light dose between 6-18 J/cm 2 ). This combined treatment leads to an additional reduction of the cell vitality by a factor of 2-3 as compared to treatment with ADR alone, suggesting that combined application of laser light and other treatment modalities might constitute a promising strategy for improvements in the tumour response.

show abstract

Section: Discussionmentioning

confidence: 98%

Improved tumour response by laser light treatment

et al. 2008

View full text Add to dashboard Cite

show abstract

“…9,33,35,37,40,46,48,52,55,66,67 Other porphyrin platform PSs such as PAD-S31, HpD, Photofrin II, Photosan III, hydroxy purpurin, mTHPP, and Protoporphyrin IX (PpIX) were studied in some articles. [56][57][58][59]62 Chlorophyll platform PSs, including chlorin e6, NPe6, chlorin p6, mTHPC, pheophorbide a, and 9-hydroxy pheophorbide a were applied in other studies . 29,31,38,39,41,43,49,54 One study used 15(1)-hydroxypurpurin-7-lactone ethyl methyl diester as a PS, which was isolated for the first time from an Araceae plant and referenced to Pha.…”

Section: Photosensitizermentioning

confidence: 99%

“…Some studies used only one concentration, 33,[38][39][40]43,45,[47][48][49]51,55,56,58,59,66,67 while others evaluated the effect of different concentrations on their cell lines. 9,23,[29][30][31][32]34,36,37,41,42,44,46,50,53,54,57,[60][61][62][63][64][65]68 Most studies showed that the results were dependent on concentrations. 9,23,[29][30][31]34,36,41,42,44,46,…”

Section: Photosensitizermentioning

confidence: 99%

In Vitro Anti-tumor Effects of Photodynamic Therapy on Oral Squamous Cell Carcinoma: A Review

et al. 2022

View full text Add to dashboard Cite

Introduction: Due to the increasing prevalence and high mortality rate of oral squamous cell carcinoma (OSCC) and problems with its routine treatments, more recent modalities like photodynamic therapy (PDT) have been developed. PDT effectively destroys tumor cells with minimum side effects. Research on in vitro effects of PDT may be helpful in determining the molecular mechanisms responsible for its effectiveness and can lead to the development of more efficient techniques. The aim of this study was to review the use of PDT in OSCC among in vitro studies. Methods: A literature search for English articles on PDT in OSCC was performed in PubMed, Scopus, Google Scholar, and Web of Science. Data were extracted based on the inclusion/exclusion criteria, which were detailed using the PICO framework: all eligible in vitro studies evaluating the effects of PDT on the viability of OSCC compared to controls without PDT were included. Results: Forty-one out of 567 studies were selected. The tongue was the most common OSCC site, 5-aminolevulinic acid was the most used photosensitizer (PS), cell viability/toxicity and apoptosis were the most evaluated outcomes, and lasers with wavelengths of 600-700 nm were the most common light sources and wavelengths respectively. Conclusion: PDT showed promising effects on reducing the viability of OSCC cells. Cell lines from various sources or even those originating from the same location sometimes responded differently to the same protocol. Considering the favorable results obtained from natural PSs and regarding their additional health-promoting properties, their use in future investigations with different cell lines and light specifications is recommended.

show abstract

“…The author also compared different anti-cancer agents combined with LITT ablation for inoperable esophageal cancer and reported that cisplatin (CDDP) was more effective than anthracyclines or cyclophosphamide when combined with Nd:YAG laser. However, other studies done in children with retinoblastoma found that Adriamycin derivatives were more cytotoxic in tumors after laser photo-thermal activation (Andreoni et al, 1991;Gallie et al, 1996;Lippert et al, 2004;Lueder and Goyal, 1996;Murphree et al, 1996). From a historical perspective, initial work on chemotherapy and lasers was reported in clinical models investigating combined palliative therapy for inoperable esophageal cancers.…”

Section: Clinical Relevance Of Laser and Cisplatin In Photo Chemotherapymentioning

confidence: 99%

Laser Photo Chemotherapy: An Alternative Treatment for Cancer

Paiva¹,

Palumbo²,

Greggio³

et al. 2011

Current Cancer Treatment - Novel Beyond Conventional Approaches

View full text Add to dashboard Cite

Photodynamic effects of anthracyclin derivatives on squamous cell carcinoma cell lines of the head and neck

Abstract: These results revealed that the above mentioned cytostatics could be considered as possible alternative photosensitizer for photodynamic therapy.

Cited by 7 publications

References 27 publications

Improved tumour response by laser light treatment

Improved tumour response by laser light treatment

In Vitro Anti-tumor Effects of Photodynamic Therapy on Oral Squamous Cell Carcinoma: A Review

Laser Photo Chemotherapy: An Alternative Treatment for Cancer

Contact Info

Product

Resources

About