Photodynamic destruction of human bladder carcinoma

Abstract

Eleven human bladder carcinomata of different degrees of differentiation were implanted in mice immunosuppressed by thymectomy, anti-thymocyte serum and x-rays. Seven carcinomata grew well and one poorly and 3 produced mainly fibrous nodules in the mice. Normal human bladder tissues were grown from 4 other patients. The administration of a haematoporphyrin derivative (HpD), followed 24 h later by exposure to white light, caused marked destruction of tumours but little or none of normal bladder tissues. HpD or light alone caused no damage to tumours or normal tissues. It is suggested that photodynamic therapy may be applicable in the treatment of superficial transitional cell carcinoma of the bladder. Images Fig. 2 Fig. 3

Photochemically stimulated drug delivery increases the cytotoxicity and specificity of EGF–saporin

“…Throughout the first part of the 20 th century some reports on PS accumulation in tumours were published (Daniell & Hill 1991, Macdonald & Dougherty 2001. However, it was not until the 1970s, when haematoporphyrin derivate-induced PDT was shown to induce long-term cures of several cancers in vivo (Dougherty et al 1975, Kelly et al 1975, that the development of PDT was seriously escalated.…”

Photodynamic effects of haematoporphyrin derivative on synchronized and asynchronous cells of different origin

“…A selective effect of the treatment on malignant tissue has been demonstrated (Kelly et al, 1975). The most probable reason for this selectivity is a selective accumulation of HPD in malignant tissue.…”

The mechanism of photodynamic inactivation of human cells in vitro in the presence of haematoporphyrin

“…The most promising aspect of photosensitization in medicine seems to be cancer therapy. It is well documented that a few dyes, among them haematoporphyrin, are preferentially taken up and retained by malignant tumours in animals as well as in humans (Auler & Banzer, 1942;Figge et al, 1]948; Lipson et al, 1961;Gregorie et al, 1968;Winkelman & Rasmussen-Taxdal, 1969 (Kelly et al, 1975;Granelli et al, 1975;Dougherty et al, 1976). Particularly promising is the recent work of Dougherty et al (1978) in which the authors document complete or partial remission of 111/113 cutaneous or subcutaneous malignant tumours of different types in humans.…”