Photodynamic antibacterial effect of graphene quantum dots

Ristić, Biljana; Milenković, Marina; Dakić, Ivana; Marković, Biljana M. Todorović; Milosavljević, M.; Budimir, Milica; Paunović, Verica; Dramićanin, Miroslav; Marković, Zoran M.; Trajkovič, Vladimir

doi:10.1016/j.biomaterials.2014.02.014

Cited by 362 publications

(218 citation statements)

References 34 publications

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“…This suggests that FCNPs from C. vagabunda has antimicrobial activity against both Gram-positive and Gram-negative bacteria. This result is consistent with the study of Ristic et al, 56 , where GQD nanoparticle showed a concentration-dependent cytotoxic effect against S. aureus and E. coli when treated under UV light. However, in this study, the bioactivity of produced FCNPs were active despite the absence of UV light.…”

Section: Phytochemistry Of As-prepared Fcnpssupporting

confidence: 82%

Facile Synthesis of Biologically Derived Fluorescent Carbon Nanoparticles (Fcnps) from an Abundant Marine Alga and its Biological Activities

Calangian¹,

Ildefonzo²,

Manzano³

et al. 2018

Orient. J. Chem

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Biologically derived carbon-based nanomaterials have been gaining attention in the recent years due to its various potential medical applications. In this study, fluorescent carbon nanoparticles (FCNPs) derived from an abundant alga, Cladophora vagabunda, is first reported. FCNPs with an average diameter of ~43 nm was synthesized via hydrothermal process, a simple and green method. The synthesized FCNPs exhibited absorbances in the ultraviolet to visible regions and emissions at 600 and 650 nm. Phytochemical screening and bioactivity tests were conducted to determine various bioactive compounds present in the FCNP surface and its antibacterial, antioxidant, and cytotoxic properties. Results showed that FCNPs from C. vagabunda contains tannin, saponin, flavonoids, and phenolic compounds which are known for their antimicrobial property as supported by the result of agar well diffusion method using a Gram-positive S. aureus and Gram-negative E. coli. Moreover, FCNPs shows inactive cytotoxicity using brine shrimp lethality test at ratio as high as 1:1 in 40% (v/v) ethanol. The results suggest the potential use of FCNPs from C. vagabunda as a fluorescent material with various biological activities.

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Section: Phytochemistry Of As-prepared Fcnpssupporting

confidence: 82%

Facile Synthesis of Biologically Derived Fluorescent Carbon Nanoparticles (Fcnps) from an Abundant Marine Alga and its Biological Activities

Calangian¹,

Ildefonzo²,

Manzano³

et al. 2018

Orient. J. Chem

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show abstract

“…As related, there have been a few studies of using “graphene quantum dots” as photodynamic agents. 9, 29, 30 In the study by Ristic et al, 9 antibacterial activities were observed with 470 nm light irradiation of the graphene quantum dots obtained from the electrochemical method. Those dots are essentially graphitic nanoparticles, which share optical properties similar to those of the precursor carbon nanoparticles for carbon dots.…”

Section: Resultsmentioning

confidence: 99%

“…3–6 Alternative semiconductors and other nanomaterials for visible-light-responsive antibacterial activities have been pursued. 7–9 Visible-light activation considerably broadens the reach of the photochemical antimicrobial agents, potentially enabling their uses under solar irradiation or natural-light exposure to inhibit the growth of pathogens and other infectious agents. Our focus has been on exploring the newly developed carbon “quantum” dots, or more appropriately called carbon dots for their lack of classical quantum confinement behavior, 10 for their visible-light-activated bactericidal functions.…”

Section: Introductionmentioning

confidence: 99%

Visible-Light-Activated Bactericidal Functions of Carbon “Quantum” Dots

Meziani

Dong

Zhu³

et al. 2016

ACS Appl. Mater. Interfaces

220

168

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Carbon dots, generally defined as small carbon nanoparticles with various surface passivation schemes, have emerged as a new class of quantum-dot-like nanomaterials, with their optical properties and photocatalytic functions resembling those typically found in conventional nanoscale semiconductors. In this work, carbon dots were evaluated for their photoinduced bactericidal functions, with the results suggesting that the dots were highly effective in bacteria-killing with visible-light illumination. In fact, the inhibition effect could be observed even simply under ambient room lighting conditions. Mechanistic implications of the results are discussed and so are opportunities in the further development of carbon dots into a new class of effective visible/natural light-responsible bactericidal agents for a variety of bacteria control applications.

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“…Some researchers found that graphene could damage the cell membrane of Escherichia coli ( E . coli ) and thereby, showed strong antibacterial activity [3,4]. …”

Section: Introductionmentioning

confidence: 99%

Investigating the Influence of MoS2 Nanosheets on E. coli from Metabolomics Level

et al. 2016

PLoS ONE

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Molybdenum disulfide, a type of two-dimensional layered material with unique properties, has been widely used in many fields. However, an exact understanding of its toxicity remains elusive, let alone its effects on the environmental microbial community. In this study, we utilized metabolomics technology to explore the effects of different concentrations of molybdenum disulfide nanosheets on Escherichia coli for the first time. The results showed that with increasing concentration of molybdenum disulfide nanosheets, the survival rate of Escherichia coli was decreased and the release of lactic dehydrogenase was increased. At the same time, intracellular concentrations of reactive oxygen species were dramatically increased. In addition, metabolomics analysis showed that high concentrations of molybdenum disulfide nanosheets (100, 1000 μg/mL) could significantly affect the metabolic profile of Escherichia coli, including glycine, serine and threonine metabolism, protein biosynthesis, urea cycle and pyruvate metabolism. These results will be beneficial for molybdenum disulfide toxicity assessment and further applications.

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Photodynamic antibacterial effect of graphene quantum dots

Cited by 362 publications

References 34 publications

Facile Synthesis of Biologically Derived Fluorescent Carbon Nanoparticles (Fcnps) from an Abundant Marine Alga and its Biological Activities

Facile Synthesis of Biologically Derived Fluorescent Carbon Nanoparticles (Fcnps) from an Abundant Marine Alga and its Biological Activities

Visible-Light-Activated Bactericidal Functions of Carbon “Quantum” Dots

Investigating the Influence of MoS2 Nanosheets on E. coli from Metabolomics Level

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